The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells
Abstract N-terminal HSP90 inhibitors in development have had issues arising from heat shock response (HSR) induction and off-target effects. We sought to investigate the capacity of NCT-58, a rationally-synthesized C-terminal HSP90 inhibitor, to kill trastuzumab-resistant HER2-positive breast cancer...
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Autores principales: | Soeun Park, Yoon-Jae Kim, Jung Min Park, Minsu Park, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Publishing Group
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/5abd2556d6fa4f7bb936d8f0108b8169 |
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