PROGNOSIS FOR PREDISPOSAL TO DEVELOPMENT OF VIRAL HEPATITIS C BASED ON G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, AND C-592A IL-10 GENE POLYMORPHISMS

Abstract. The main objective of this work was to identify allelic variants of cytokine genes at the polymorphic positions of G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, and C-592A IL-10, and to assess their contribution to predisposition and resistance of human patients to progression of vir...

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Autores principales:	V. V. Avdoshina, V. V. Dortman, V. I. Konenkov, E. V. Beloborodova, N. V. Ryasantseva, I. O. Naslednikova, V. V. Novitsky
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	viral hepatitis c allelic variants cytokine genes il-4 il-5 il-10 il-2 tnf Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5ac2f30609df4e7199e2e9ae28988fcd
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spelling	oai:doaj.org-article:5ac2f30609df4e7199e2e9ae28988fcd2021-11-18T08:03:42ZPROGNOSIS FOR PREDISPOSAL TO DEVELOPMENT OF VIRAL HEPATITIS C BASED ON G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, AND C-592A IL-10 GENE POLYMORPHISMS1563-06252313-741X10.15789/1563-0625-2006-5-6-715-720https://doaj.org/article/5ac2f30609df4e7199e2e9ae28988fcd2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/581https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The main objective of this work was to identify allelic variants of cytokine genes at the polymorphic positions of G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, and C-592A IL-10, and to assess their contribution to predisposition and resistance of human patients to progression of viral hepatitis C infection. We observed significant increase in frequency of T/G T-330G IL-2 genotype in HCV-infected patients, as compared to healthy individuals. Distribution analysis of C-590T promoter alleles of the IL-4 gene displayed a wide overrepresentation of C/T genotype among HCV-infected patients. Likewise, we have shown the G/A genotype of G-308A TNFA to be highly frequent in the group of HCV-infected patients, whereas this genotype was rare in the sample of healthy persons. When analysing allelic frequencies of cytokine genes at these polymorphic positions, we get an opportunity to predict predisposal for the chronic variant of viral hepatitis C in HCV-infected persons.V. V. AvdoshinaV. V. DortmanV. I. KonenkovE. V. BeloborodovaN. V. RyasantsevaI. O. NaslednikovaV. V. NovitskySPb RAACIarticleviral hepatitis callelic variantscytokine genesil-4il-5il-10il-2tnfImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 5-6, Pp 715-720 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	viral hepatitis c allelic variants cytokine genes il-4 il-5 il-10 il-2 tnf Immunologic diseases. Allergy RC581-607
spellingShingle	viral hepatitis c allelic variants cytokine genes il-4 il-5 il-10 il-2 tnf Immunologic diseases. Allergy RC581-607 V. V. Avdoshina V. V. Dortman V. I. Konenkov E. V. Beloborodova N. V. Ryasantseva I. O. Naslednikova V. V. Novitsky PROGNOSIS FOR PREDISPOSAL TO DEVELOPMENT OF VIRAL HEPATITIS C BASED ON G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, AND C-592A IL-10 GENE POLYMORPHISMS
description	Abstract. The main objective of this work was to identify allelic variants of cytokine genes at the polymorphic positions of G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, and C-592A IL-10, and to assess their contribution to predisposition and resistance of human patients to progression of viral hepatitis C infection. We observed significant increase in frequency of T/G T-330G IL-2 genotype in HCV-infected patients, as compared to healthy individuals. Distribution analysis of C-590T promoter alleles of the IL-4 gene displayed a wide overrepresentation of C/T genotype among HCV-infected patients. Likewise, we have shown the G/A genotype of G-308A TNFA to be highly frequent in the group of HCV-infected patients, whereas this genotype was rare in the sample of healthy persons. When analysing allelic frequencies of cytokine genes at these polymorphic positions, we get an opportunity to predict predisposal for the chronic variant of viral hepatitis C in HCV-infected persons.
format	article
author	V. V. Avdoshina V. V. Dortman V. I. Konenkov E. V. Beloborodova N. V. Ryasantseva I. O. Naslednikova V. V. Novitsky
author_facet	V. V. Avdoshina V. V. Dortman V. I. Konenkov E. V. Beloborodova N. V. Ryasantseva I. O. Naslednikova V. V. Novitsky
author_sort	V. V. Avdoshina
title	PROGNOSIS FOR PREDISPOSAL TO DEVELOPMENT OF VIRAL HEPATITIS C BASED ON G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, AND C-592A IL-10 GENE POLYMORPHISMS
title_short	PROGNOSIS FOR PREDISPOSAL TO DEVELOPMENT OF VIRAL HEPATITIS C BASED ON G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, AND C-592A IL-10 GENE POLYMORPHISMS
title_full	PROGNOSIS FOR PREDISPOSAL TO DEVELOPMENT OF VIRAL HEPATITIS C BASED ON G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, AND C-592A IL-10 GENE POLYMORPHISMS
title_fullStr	PROGNOSIS FOR PREDISPOSAL TO DEVELOPMENT OF VIRAL HEPATITIS C BASED ON G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, AND C-592A IL-10 GENE POLYMORPHISMS
title_full_unstemmed	PROGNOSIS FOR PREDISPOSAL TO DEVELOPMENT OF VIRAL HEPATITIS C BASED ON G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, AND C-592A IL-10 GENE POLYMORPHISMS
title_sort	prognosis for predisposal to development of viral hepatitis c based on g-308a tnfа, t-330g il-2, с-590т il-4, с-703т il-5, and c-592a il-10 gene polymorphisms
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/5ac2f30609df4e7199e2e9ae28988fcd
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_version_	1718422478109278208

PROGNOSIS FOR PREDISPOSAL TO DEVELOPMENT OF VIRAL HEPATITIS C BASED ON G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, AND C-592A IL-10 GENE POLYMORPHISMS

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