Effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes

Jie Zhuang1, Qineng Ping1, Yunmei Song2, Jianping Qi1, Zheng Cui31School of Pharmacy, China Pharmaceutical University, Nanjing, China; 2School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia; 3School of Pharmacy, Peking University, Beijing, ChinaAbstract: The obj...

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Autores principales:	Jie Zhuang, Qineng Ping, Yunmei Song, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5ac5c7cad8cd4df88de01cd518025d82
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spelling	oai:doaj.org-article:5ac5c7cad8cd4df88de01cd518025d822021-12-02T02:42:31ZEffects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes1176-91141178-2013https://doaj.org/article/5ac5c7cad8cd4df88de01cd518025d822010-06-01T00:00:00Zhttp://www.dovepress.com/effects-of-chitosan-coating-on-physical-properties-and-pharmacokinetic-a4630https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Jie Zhuang1, Qineng Ping1, Yunmei Song2, Jianping Qi1, Zheng Cui31School of Pharmacy, China Pharmaceutical University, Nanjing, China; 2School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia; 3School of Pharmacy, Peking University, Beijing, ChinaAbstract: The objective of this work was to evaluate the physical properties and in vivo circulation of chitosan (CH)-coated liposomes of mitoxantrone (MTO). Changes in particle size and zeta potential confirmed the existence of a coating layer on the surface of liposomes. The in vitro release of adsorbed CH from the liposomes was significantly slower than CH solution, indicating the stable interaction between CH and liposomes. The physical stability of the CH-coated liposomes was evaluated by measuring the change in particle size before and after freeze-drying and rehydration. The smallest change was observed when saturated adsorption of CH occurred (0.3%). The sustained release in vitro of MTO from CH-coated liposomes confirmed the increased stability of liposomes. Systemic circulation of CH-coated MTO liposomes was examined. The 0.3% CH-coated liposomes showed the longest circulation time. It could be concluded that the prolonged retention time of the liposomes was closely related with CH coating and its stability effect.Keywords: liposomes, chitosan coating, stability, in vitro release, prolonged retention time Jie ZhuangQineng PingYunmei Songet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 407-416 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jie Zhuang Qineng Ping Yunmei Song et al Effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes
description	Jie Zhuang1, Qineng Ping1, Yunmei Song2, Jianping Qi1, Zheng Cui31School of Pharmacy, China Pharmaceutical University, Nanjing, China; 2School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia; 3School of Pharmacy, Peking University, Beijing, ChinaAbstract: The objective of this work was to evaluate the physical properties and in vivo circulation of chitosan (CH)-coated liposomes of mitoxantrone (MTO). Changes in particle size and zeta potential confirmed the existence of a coating layer on the surface of liposomes. The in vitro release of adsorbed CH from the liposomes was significantly slower than CH solution, indicating the stable interaction between CH and liposomes. The physical stability of the CH-coated liposomes was evaluated by measuring the change in particle size before and after freeze-drying and rehydration. The smallest change was observed when saturated adsorption of CH occurred (0.3%). The sustained release in vitro of MTO from CH-coated liposomes confirmed the increased stability of liposomes. Systemic circulation of CH-coated MTO liposomes was examined. The 0.3% CH-coated liposomes showed the longest circulation time. It could be concluded that the prolonged retention time of the liposomes was closely related with CH coating and its stability effect.Keywords: liposomes, chitosan coating, stability, in vitro release, prolonged retention time
format	article
author	Jie Zhuang Qineng Ping Yunmei Song et al
author_facet	Jie Zhuang Qineng Ping Yunmei Song et al
author_sort	Jie Zhuang
title	Effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes
title_short	Effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes
title_full	Effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes
title_fullStr	Effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes
title_full_unstemmed	Effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes
title_sort	effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/5ac5c7cad8cd4df88de01cd518025d82
work_keys_str_mv	AT jiezhuang effectsofchitosancoatingonphysicalpropertiesandpharmacokineticbehaviorofmitoxantroneliposomes AT qinengping effectsofchitosancoatingonphysicalpropertiesandpharmacokineticbehaviorofmitoxantroneliposomes AT yunmeisong effectsofchitosancoatingonphysicalpropertiesandpharmacokineticbehaviorofmitoxantroneliposomes AT etal effectsofchitosancoatingonphysicalpropertiesandpharmacokineticbehaviorofmitoxantroneliposomes
_version_	1718402220261638144

Effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes

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