THE EFFICACY, SIDE-EFFECTS, AND MORTALITY COMPARISON BETWEEN PARACETAMOL AND IBUPROFEN IN PATENT DUCTUS ARTERIOSUS TREATMENT FOR PREMATURE INFANTS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, have long been a standard pharmacotherapy for patent ductus arteriosus (PDA). However, recently, paracetamol has also proven to produce the same effect by preventing prostaglandin synthesis. Several studies have compared the efficacy a...

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Autor principal:	Lokot Donna Lubis
Formato:	article
Lenguaje:	EN
Publicado:	Associazione Italiana Giovani Medici 2021
Materias:	ibuprofen paracetamol patent ductus arteriosus preterm Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5ac5cf6690364221b1fc0fb49ad3f9b0
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id	oai:doaj.org-article:5ac5cf6690364221b1fc0fb49ad3f9b0
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spelling	oai:doaj.org-article:5ac5cf6690364221b1fc0fb49ad3f9b02021-11-11T18:24:03ZTHE EFFICACY, SIDE-EFFECTS, AND MORTALITY COMPARISON BETWEEN PARACETAMOL AND IBUPROFEN IN PATENT DUCTUS ARTERIOSUS TREATMENT FOR PREMATURE INFANTS: A SYSTEMATIC REVIEW AND META-ANALYSIS 10.3269/1970-5492.2021.16.292279-7165https://doaj.org/article/5ac5cf6690364221b1fc0fb49ad3f9b02021-11-01T00:00:00Zhttp://www.embj.org/wp-content/uploads/2021/11/Lubis_29.pdfhttps://doaj.org/toc/2279-7165Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, have long been a standard pharmacotherapy for patent ductus arteriosus (PDA). However, recently, paracetamol has also proven to produce the same effect by preventing prostaglandin synthesis. Several studies have compared the efficacy and side-effects of both drugs, but the results are not straightforward. The meta-analysis aims to compare the efficacy, side effects, and mortality of ibuprofen and paracetamol for treatment of PDA in preterm infants. Relevant articles were searched for on PubMed, Clinical Key, EMBASE, Cochrane Database, and Google Scholar before the study’s quality was assessed using the Jadad criteria and the data were analyzed using Review Manager. Fifteen clinical studies with 1477 preterm infants as the samples were analyzed using a meta-analysis. No significant statistical difference was found between the efficacy of paracetamol and ibuprofen in the DA closure and mortality cases. Meanwhile, for oliguria, kidney disease, and gastrointestinal bleeding, significant statistical difference was found with a lower risk in paracetamol. Lokot Donna LubisAssociazione Italiana Giovani Mediciarticleibuprofenparacetamolpatent ductus arteriosuspretermMedicine (General)R5-920ENEuromediterranean Biomedical Journal, Vol 16, Iss 29, Pp 124-130 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ibuprofen paracetamol patent ductus arteriosus preterm Medicine (General) R5-920
spellingShingle	ibuprofen paracetamol patent ductus arteriosus preterm Medicine (General) R5-920 Lokot Donna Lubis THE EFFICACY, SIDE-EFFECTS, AND MORTALITY COMPARISON BETWEEN PARACETAMOL AND IBUPROFEN IN PATENT DUCTUS ARTERIOSUS TREATMENT FOR PREMATURE INFANTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
description	Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, have long been a standard pharmacotherapy for patent ductus arteriosus (PDA). However, recently, paracetamol has also proven to produce the same effect by preventing prostaglandin synthesis. Several studies have compared the efficacy and side-effects of both drugs, but the results are not straightforward. The meta-analysis aims to compare the efficacy, side effects, and mortality of ibuprofen and paracetamol for treatment of PDA in preterm infants. Relevant articles were searched for on PubMed, Clinical Key, EMBASE, Cochrane Database, and Google Scholar before the study’s quality was assessed using the Jadad criteria and the data were analyzed using Review Manager. Fifteen clinical studies with 1477 preterm infants as the samples were analyzed using a meta-analysis. No significant statistical difference was found between the efficacy of paracetamol and ibuprofen in the DA closure and mortality cases. Meanwhile, for oliguria, kidney disease, and gastrointestinal bleeding, significant statistical difference was found with a lower risk in paracetamol.
format	article
author	Lokot Donna Lubis
author_facet	Lokot Donna Lubis
author_sort	Lokot Donna Lubis
title	THE EFFICACY, SIDE-EFFECTS, AND MORTALITY COMPARISON BETWEEN PARACETAMOL AND IBUPROFEN IN PATENT DUCTUS ARTERIOSUS TREATMENT FOR PREMATURE INFANTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
title_short	THE EFFICACY, SIDE-EFFECTS, AND MORTALITY COMPARISON BETWEEN PARACETAMOL AND IBUPROFEN IN PATENT DUCTUS ARTERIOSUS TREATMENT FOR PREMATURE INFANTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
title_full	THE EFFICACY, SIDE-EFFECTS, AND MORTALITY COMPARISON BETWEEN PARACETAMOL AND IBUPROFEN IN PATENT DUCTUS ARTERIOSUS TREATMENT FOR PREMATURE INFANTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
title_fullStr	THE EFFICACY, SIDE-EFFECTS, AND MORTALITY COMPARISON BETWEEN PARACETAMOL AND IBUPROFEN IN PATENT DUCTUS ARTERIOSUS TREATMENT FOR PREMATURE INFANTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
title_full_unstemmed	THE EFFICACY, SIDE-EFFECTS, AND MORTALITY COMPARISON BETWEEN PARACETAMOL AND IBUPROFEN IN PATENT DUCTUS ARTERIOSUS TREATMENT FOR PREMATURE INFANTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
title_sort	efficacy, side-effects, and mortality comparison between paracetamol and ibuprofen in patent ductus arteriosus treatment for premature infants: a systematic review and meta-analysis
publisher	Associazione Italiana Giovani Medici
publishDate	2021
url	https://doaj.org/article/5ac5cf6690364221b1fc0fb49ad3f9b0
work_keys_str_mv	AT lokotdonnalubis theefficacysideeffectsandmortalitycomparisonbetweenparacetamolandibuprofeninpatentductusarteriosustreatmentforprematureinfantsasystematicreviewandmetaanalysis AT lokotdonnalubis efficacysideeffectsandmortalitycomparisonbetweenparacetamolandibuprofeninpatentductusarteriosustreatmentforprematureinfantsasystematicreviewandmetaanalysis
_version_	1718431824252764160

THE EFFICACY, SIDE-EFFECTS, AND MORTALITY COMPARISON BETWEEN PARACETAMOL AND IBUPROFEN IN PATENT DUCTUS ARTERIOSUS TREATMENT FOR PREMATURE INFANTS: A SYSTEMATIC REVIEW AND META-ANALYSIS

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