Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope
ABSTRACT Only one naturally occurring human antibody has been described thus far that is capable of potently neutralizing all five ebolaviruses. Here we present two crystal structures of this rare, pan-ebolavirus neutralizing human antibody in complex with Ebola virus and Bundibugyo virus glycoprote...
Saved in:
Main Authors: | Brandyn R. West, Crystal L. Moyer, Liam B. King, Marnie L. Fusco, Jacob C. Milligan, Sean Hui, Erica Ollmann Saphire |
---|---|
Format: | article |
Language: | EN |
Published: |
American Society for Microbiology
2018
|
Subjects: | |
Online Access: | https://doaj.org/article/5ac7f3a7134e439788c3a2f6d1f411d9 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment
by: Sara Landeras-Bueno, et al.
Published: (2019) -
Tenacious Researchers Identify a Weakness in All Ebolaviruses
by: Rebecca M. DuBois
Published: (2018) -
A Bispecific Antibody That Simultaneously Recognizes the V2- and V3-Glycan Epitopes of the HIV-1 Envelope Glycoprotein Is Broader and More Potent than Its Parental Antibodies
by: Meredith E. Davis-Gardner, et al.
Published: (2020) -
A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry
by: J. Maximilian Fels, et al.
Published: (2019) -
Risks Posed by Reston, the Forgotten Ebolavirus
by: Diego Cantoni, et al.
Published: (2016)