Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.

Stat3 has a defined role in mammary gland where it is a critical mediator of cell death during post-lactational regression. On the other hand, Stat3 is required for the self-renewal of embryonic stem cells and is sufficient for the induction of a naïve pluripotent state in epiblast stem cells. Mamma...

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Autores principales:	Anna D Staniszewska, Sara Pensa, Maria M Caffarel, Lisa H Anderson, Valeria Poli, Christine J Watson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5acd9db09c3348f2a1440d4de3512b98
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spelling	oai:doaj.org-article:5acd9db09c3348f2a1440d4de3512b982021-11-18T08:04:06ZStat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.1932-620310.1371/journal.pone.0052608https://doaj.org/article/5acd9db09c3348f2a1440d4de3512b982012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23285109/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Stat3 has a defined role in mammary gland where it is a critical mediator of cell death during post-lactational regression. On the other hand, Stat3 is required for the self-renewal of embryonic stem cells and is sufficient for the induction of a naïve pluripotent state in epiblast stem cells. Mammary stem cells (MaSCs) have a high capacity for self-renewal and can grow robustly in transplantation experiments in vivo. However, a role for Stat3 in MaSCs has not been investigated. Here we show that depletion of Stat3 from basal cells results in reduced primary transplantation efficiency and diminishes the potential to generate ductal, but not alveolar, outgrowths. In addition, Stat3 is required for maximal proliferation of luminal progenitors.Anna D StaniszewskaSara PensaMaria M CaffarelLisa H AndersonValeria PoliChristine J WatsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52608 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna D Staniszewska Sara Pensa Maria M Caffarel Lisa H Anderson Valeria Poli Christine J Watson Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.
description	Stat3 has a defined role in mammary gland where it is a critical mediator of cell death during post-lactational regression. On the other hand, Stat3 is required for the self-renewal of embryonic stem cells and is sufficient for the induction of a naïve pluripotent state in epiblast stem cells. Mammary stem cells (MaSCs) have a high capacity for self-renewal and can grow robustly in transplantation experiments in vivo. However, a role for Stat3 in MaSCs has not been investigated. Here we show that depletion of Stat3 from basal cells results in reduced primary transplantation efficiency and diminishes the potential to generate ductal, but not alveolar, outgrowths. In addition, Stat3 is required for maximal proliferation of luminal progenitors.
format	article
author	Anna D Staniszewska Sara Pensa Maria M Caffarel Lisa H Anderson Valeria Poli Christine J Watson
author_facet	Anna D Staniszewska Sara Pensa Maria M Caffarel Lisa H Anderson Valeria Poli Christine J Watson
author_sort	Anna D Staniszewska
title	Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.
title_short	Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.
title_full	Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.
title_fullStr	Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.
title_full_unstemmed	Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.
title_sort	stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5acd9db09c3348f2a1440d4de3512b98
work_keys_str_mv	AT annadstaniszewska stat3isrequiredtomaintainthefulldifferentiationpotentialofmammarystemcellsandtheproliferativepotentialofmammaryluminalprogenitors AT sarapensa stat3isrequiredtomaintainthefulldifferentiationpotentialofmammarystemcellsandtheproliferativepotentialofmammaryluminalprogenitors AT mariamcaffarel stat3isrequiredtomaintainthefulldifferentiationpotentialofmammarystemcellsandtheproliferativepotentialofmammaryluminalprogenitors AT lisahanderson stat3isrequiredtomaintainthefulldifferentiationpotentialofmammarystemcellsandtheproliferativepotentialofmammaryluminalprogenitors AT valeriapoli stat3isrequiredtomaintainthefulldifferentiationpotentialofmammarystemcellsandtheproliferativepotentialofmammaryluminalprogenitors AT christinejwatson stat3isrequiredtomaintainthefulldifferentiationpotentialofmammarystemcellsandtheproliferativepotentialofmammaryluminalprogenitors
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Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.

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