Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants

ABSTRACT The recent emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a significant concern for public health worldwide. New variants have been classified either as variants of concern (VOCs) or variants of interest (VOIs) by the CDC (USA) and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chiranjib Chakraborty, Ashish Ranjan Sharma, Manojit Bhattacharya, Govindasamy Agoramoorthy, Sang-Soo Lee
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	emerging variants transmission pattern mutational landscape effect on vaccines Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/5acfbc93fd5c4ffebcc47a2457fa79d1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5acfbc93fd5c4ffebcc47a2457fa79d1
record_format	dspace
spelling	oai:doaj.org-article:5acfbc93fd5c4ffebcc47a2457fa79d12021-11-10T18:37:50ZEvolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants10.1128/mBio.01140-212150-7511https://doaj.org/article/5acfbc93fd5c4ffebcc47a2457fa79d12021-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01140-21https://doaj.org/toc/2150-7511ABSTRACT The recent emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a significant concern for public health worldwide. New variants have been classified either as variants of concern (VOCs) or variants of interest (VOIs) by the CDC (USA) and WHO. The VOCs include lineages such as B.1.1.7 (20I/501Y.V1 variant), P.1 (20J/501Y.V3 variant), B.1.351 (20H/501Y.V2 variant), and B.1.617.2. In contrast, the VOI category includes B.1.525, B.1.526, P.2, and B.1.427/B.1.429. The WHO provided the alert for last two variants (P.2 and B.1.427/B.1.429) and labeled them for further monitoring. As per the WHO, these variants can be reclassified due to their status at a particular time. At the same time, the CDC (USA) has marked these two variants as VOIs up through today. This article analyzes the evolutionary patterns of all these emerging variants, as well as their geographical distributions and transmission patterns, including the circulating frequency, entropy diversity, and mutational event diversity throughout the genomes of all SARS-CoV-2 lineages. The transmission pattern was observed highest in the B.1.1.7 lineage. Our frequency evaluation found that this lineage achieved 100% frequency in early October 2020. We also critically evaluated the above emerging variants mutational landscape and significant spike protein mutations (E484K, K417T/N, N501Y, and D614G) impacting public health. Finally, the effectiveness of vaccines against newly SARS-CoV-2 variants was also analyzed. IMPORTANCE Irrespective of the aggressive vaccination drive, the newly emerging multiple SARS-CoV-2 variants are causing havoc in several countries. As per the CDC (USA) and WHO, the VOCs include the B.1.1.7, P.1, B.1.351, and B.1.617.2 lineages, while the VOIs include the B.1.525, B.1.526, P.2, and B.1.427/B.1.429 lineages. This study analyzed the evolutionary patterns, geographical distributions and transmission patterns, circulating frequency, entropy diversity, and mutational event diversity throughout the genome of significant SARS-CoV-2 lineages. A higher transmission pattern was observed for the B.1.1.7 variant. The study also evaluated the mutational landscape and important spike protein mutations (E484K, K417T/N, N501Y, and D614G) of all of the above variants. Finally, a survey was performed on the efficacy of vaccines against these variants from the previously published literature. The results presented in this article will help design future countrywide pandemic planning strategies for the emerging variants, next-generation vaccine development using alternative wild-type antigens and significant viral antigens, and immediate planning for ongoing vaccination programs worldwide.Chiranjib ChakrabortyAshish Ranjan SharmaManojit BhattacharyaGovindasamy AgoramoorthySang-Soo LeeAmerican Society for Microbiologyarticleemerging variantstransmission patternmutational landscapeeffect on vaccinesMicrobiologyQR1-502ENmBio, Vol 12, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	emerging variants transmission pattern mutational landscape effect on vaccines Microbiology QR1-502
spellingShingle	emerging variants transmission pattern mutational landscape effect on vaccines Microbiology QR1-502 Chiranjib Chakraborty Ashish Ranjan Sharma Manojit Bhattacharya Govindasamy Agoramoorthy Sang-Soo Lee Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants
description	ABSTRACT The recent emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a significant concern for public health worldwide. New variants have been classified either as variants of concern (VOCs) or variants of interest (VOIs) by the CDC (USA) and WHO. The VOCs include lineages such as B.1.1.7 (20I/501Y.V1 variant), P.1 (20J/501Y.V3 variant), B.1.351 (20H/501Y.V2 variant), and B.1.617.2. In contrast, the VOI category includes B.1.525, B.1.526, P.2, and B.1.427/B.1.429. The WHO provided the alert for last two variants (P.2 and B.1.427/B.1.429) and labeled them for further monitoring. As per the WHO, these variants can be reclassified due to their status at a particular time. At the same time, the CDC (USA) has marked these two variants as VOIs up through today. This article analyzes the evolutionary patterns of all these emerging variants, as well as their geographical distributions and transmission patterns, including the circulating frequency, entropy diversity, and mutational event diversity throughout the genomes of all SARS-CoV-2 lineages. The transmission pattern was observed highest in the B.1.1.7 lineage. Our frequency evaluation found that this lineage achieved 100% frequency in early October 2020. We also critically evaluated the above emerging variants mutational landscape and significant spike protein mutations (E484K, K417T/N, N501Y, and D614G) impacting public health. Finally, the effectiveness of vaccines against newly SARS-CoV-2 variants was also analyzed. IMPORTANCE Irrespective of the aggressive vaccination drive, the newly emerging multiple SARS-CoV-2 variants are causing havoc in several countries. As per the CDC (USA) and WHO, the VOCs include the B.1.1.7, P.1, B.1.351, and B.1.617.2 lineages, while the VOIs include the B.1.525, B.1.526, P.2, and B.1.427/B.1.429 lineages. This study analyzed the evolutionary patterns, geographical distributions and transmission patterns, circulating frequency, entropy diversity, and mutational event diversity throughout the genome of significant SARS-CoV-2 lineages. A higher transmission pattern was observed for the B.1.1.7 variant. The study also evaluated the mutational landscape and important spike protein mutations (E484K, K417T/N, N501Y, and D614G) of all of the above variants. Finally, a survey was performed on the efficacy of vaccines against these variants from the previously published literature. The results presented in this article will help design future countrywide pandemic planning strategies for the emerging variants, next-generation vaccine development using alternative wild-type antigens and significant viral antigens, and immediate planning for ongoing vaccination programs worldwide.
format	article
author	Chiranjib Chakraborty Ashish Ranjan Sharma Manojit Bhattacharya Govindasamy Agoramoorthy Sang-Soo Lee
author_facet	Chiranjib Chakraborty Ashish Ranjan Sharma Manojit Bhattacharya Govindasamy Agoramoorthy Sang-Soo Lee
author_sort	Chiranjib Chakraborty
title	Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants
title_short	Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants
title_full	Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants
title_fullStr	Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants
title_full_unstemmed	Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants
title_sort	evolution, mode of transmission, and mutational landscape of newly emerging sars-cov-2 variants
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/5acfbc93fd5c4ffebcc47a2457fa79d1
work_keys_str_mv	AT chiranjibchakraborty evolutionmodeoftransmissionandmutationallandscapeofnewlyemergingsarscov2variants AT ashishranjansharma evolutionmodeoftransmissionandmutationallandscapeofnewlyemergingsarscov2variants AT manojitbhattacharya evolutionmodeoftransmissionandmutationallandscapeofnewlyemergingsarscov2variants AT govindasamyagoramoorthy evolutionmodeoftransmissionandmutationallandscapeofnewlyemergingsarscov2variants AT sangsoolee evolutionmodeoftransmissionandmutationallandscapeofnewlyemergingsarscov2variants
_version_	1718439868934127616

Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants

Ejemplares similares