Could Inflammaging and Its Sequelae Be Prevented or Mitigated?

Mao-Qiang Man,1,2 Peter M Elias2 1Dermatology Hospital of Southern Medical University, Guangzhou 510091, People’s Republic of China; 2Dermatology Services, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USACorrespondence: Mao-Qiang ManDerm...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Man MQ, Elias PM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	aging inflammation inflammaging epidermis systemic disorders Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/5ad395c9c94b4391bf1888e9cf0f8d9a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5ad395c9c94b4391bf1888e9cf0f8d9a
record_format	dspace
spelling	oai:doaj.org-article:5ad395c9c94b4391bf1888e9cf0f8d9a2021-12-02T08:04:07ZCould Inflammaging and Its Sequelae Be Prevented or Mitigated?1178-1998https://doaj.org/article/5ad395c9c94b4391bf1888e9cf0f8d9a2019-12-01T00:00:00Zhttps://www.dovepress.com/could-inflammaging-and-its-sequelae-be-prevented-or-mitigated-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Mao-Qiang Man,1,2 Peter M Elias2 1Dermatology Hospital of Southern Medical University, Guangzhou 510091, People’s Republic of China; 2Dermatology Services, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USACorrespondence: Mao-Qiang ManDermatology Service (190), 4150 Clement Street, San Francisco, CA 94121, USATel +1 415 575-0539Fax +1 415 750-2106Email mqman@hotmail.comAbstract: Aged humans display a chronic and low-grade inflammation, termed “inflammaging”, which has been potentially linked to the subsequent development of some aging-associated systemic disorders, including type 2 diabetes, atherosclerotic cardiovascular disease, Alzheimer’s disease and obesity. Though the origin of aging-associated systemic inflammation is uncertain, epidemiological studies show that inflammatory dermatoses (psoriasis and eczema) are risk factors for some aging-associated systemic disorders, such as type 2 diabetes and atherosclerotic cardiovascular disease. Moreover, recent studies demonstrate that epidermal dysfunction in aged skin not only causes cutaneous inflammation, but also a subsequent increase in circulating levels of proinflammatory cytokines, suggesting that the skin could be a major contributor to inflammaging. This hypothesis is further supported by reductions in circulating levels of proinflammatory cytokines in both aged humans and murine, following improvements in epidermal function with topical emollients. Therefore, correction of epidermal dysfunction could be a novel approach for the prevention and mitigation of certain inflammation-associated chronic disorders in aged humans.Keywords: aging, inflammation, inflammaging, epidermis, systemic disordersMan MQElias PMDove Medical Pressarticleaginginflammationinflammagingepidermissystemic disordersGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 2301-2304 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging inflammation inflammaging epidermis systemic disorders Geriatrics RC952-954.6
spellingShingle	aging inflammation inflammaging epidermis systemic disorders Geriatrics RC952-954.6 Man MQ Elias PM Could Inflammaging and Its Sequelae Be Prevented or Mitigated?
description	Mao-Qiang Man,1,2 Peter M Elias2 1Dermatology Hospital of Southern Medical University, Guangzhou 510091, People’s Republic of China; 2Dermatology Services, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USACorrespondence: Mao-Qiang ManDermatology Service (190), 4150 Clement Street, San Francisco, CA 94121, USATel +1 415 575-0539Fax +1 415 750-2106Email mqman@hotmail.comAbstract: Aged humans display a chronic and low-grade inflammation, termed “inflammaging”, which has been potentially linked to the subsequent development of some aging-associated systemic disorders, including type 2 diabetes, atherosclerotic cardiovascular disease, Alzheimer’s disease and obesity. Though the origin of aging-associated systemic inflammation is uncertain, epidemiological studies show that inflammatory dermatoses (psoriasis and eczema) are risk factors for some aging-associated systemic disorders, such as type 2 diabetes and atherosclerotic cardiovascular disease. Moreover, recent studies demonstrate that epidermal dysfunction in aged skin not only causes cutaneous inflammation, but also a subsequent increase in circulating levels of proinflammatory cytokines, suggesting that the skin could be a major contributor to inflammaging. This hypothesis is further supported by reductions in circulating levels of proinflammatory cytokines in both aged humans and murine, following improvements in epidermal function with topical emollients. Therefore, correction of epidermal dysfunction could be a novel approach for the prevention and mitigation of certain inflammation-associated chronic disorders in aged humans.Keywords: aging, inflammation, inflammaging, epidermis, systemic disorders
format	article
author	Man MQ Elias PM
author_facet	Man MQ Elias PM
author_sort	Man MQ
title	Could Inflammaging and Its Sequelae Be Prevented or Mitigated?
title_short	Could Inflammaging and Its Sequelae Be Prevented or Mitigated?
title_full	Could Inflammaging and Its Sequelae Be Prevented or Mitigated?
title_fullStr	Could Inflammaging and Its Sequelae Be Prevented or Mitigated?
title_full_unstemmed	Could Inflammaging and Its Sequelae Be Prevented or Mitigated?
title_sort	could inflammaging and its sequelae be prevented or mitigated?
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/5ad395c9c94b4391bf1888e9cf0f8d9a
work_keys_str_mv	AT manmq couldinflammaginganditssequelaebepreventedormitigated AT eliaspm couldinflammaginganditssequelaebepreventedormitigated
_version_	1718398662949732352

Could Inflammaging and Its Sequelae Be Prevented or Mitigated?

Ejemplares similares