Effect of Nucleus Basalis Magnocellularis Lesions on Memory and Hippocampal Brain-Derived Neurotrophic Factor, IL-1β, Glucose, and Corticosterone Levels in Adult Rats

Background: The nucleus basalis magnocellularis (NBM) sends projections to the hippocampus that are implicated in learning and memory formation. Despite ample evidence proposing that cognitive function impairment related to neurodegeneration, it may result from alteration of biochemical substances....

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Autores principales:	Nasrin Hosseini, Maryam Radahmadi, Hojjatollah Alaei, Shabnam Nadjafi
Formato:	article
Lenguaje:	EN
Publicado:	Shahid Beheshti University of Medical Sciences 2021
Materias:	nucleus basalis magnocellularis hippocampus neurotrophic factor cytokine stress Medicine R
Acceso en línea:	https://doaj.org/article/5ad475fd71cd432688e0c68bbce96d4e
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spelling	oai:doaj.org-article:5ad475fd71cd432688e0c68bbce96d4e2021-11-16T10:50:48ZEffect of Nucleus Basalis Magnocellularis Lesions on Memory and Hippocampal Brain-Derived Neurotrophic Factor, IL-1β, Glucose, and Corticosterone Levels in Adult Rats2383-18712383-209610.34172/icnj.2021.15https://doaj.org/article/5ad475fd71cd432688e0c68bbce96d4e2021-03-01T00:00:00Zhttps://journals.sbmu.ac.ir/neuroscience/article/view/33613/26862https://doaj.org/toc/2383-1871https://doaj.org/toc/2383-2096Background: The nucleus basalis magnocellularis (NBM) sends projections to the hippocampus that are implicated in learning and memory formation. Despite ample evidence proposing that cognitive function impairment related to neurodegeneration, it may result from alteration of biochemical substances. We aimed to investigate the effects of NBM lesions on the hippocampal interleukin-1beta (IL-1β), brain-derived neurotrophic factor (BDNF), and corticosterone levels, as inflammation markers, and hallmarks of neurodegeneration, stress, and metabolic status. Methods: Thirty-six male Wistar rats were randomly put in control, sham, and NBM-lesioned groups. After inducing the lesion using an intra-NBM injection of 10 µg ibotenic acid (5 µg/µL, each side) in rats, memory was estimated using the passive avoidance test. Moreover, serum and hippocampal IL-1β levels, as well as the hippocampal corticosterone, BDNF, and glucose levels were measured after 42 days. Results: Findings indicated a significant impairment of retention at different intervals in the NBM-lesioned group. BDNF decreased whereas corticosterone, glucose, and IL-1β levels increased in the hippocampus. Also, the levels of serum IL-1β, hippocampal BDNF, corticosterone, and glucose had significant correlations with hippocampal IL-1β levels. Conclusion: The synchronous alterations of some hippocampal factors, including BDNF, corticosterone, IL-1β, and glucose, caused by NBM lesion suggest that their interaction might play a significant role in neurodegeneration and relevant learning and memory impairments.Nasrin HosseiniMaryam RadahmadiHojjatollah AlaeiShabnam NadjafiShahid Beheshti University of Medical Sciencesarticlenucleus basalis magnocellularishippocampusneurotrophic factorcytokinestressMedicineRENInternational Clinical Neuroscience Journal, Vol 8, Iss 2, Pp 67-75 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nucleus basalis magnocellularis hippocampus neurotrophic factor cytokine stress Medicine R
spellingShingle	nucleus basalis magnocellularis hippocampus neurotrophic factor cytokine stress Medicine R Nasrin Hosseini Maryam Radahmadi Hojjatollah Alaei Shabnam Nadjafi Effect of Nucleus Basalis Magnocellularis Lesions on Memory and Hippocampal Brain-Derived Neurotrophic Factor, IL-1β, Glucose, and Corticosterone Levels in Adult Rats
description	Background: The nucleus basalis magnocellularis (NBM) sends projections to the hippocampus that are implicated in learning and memory formation. Despite ample evidence proposing that cognitive function impairment related to neurodegeneration, it may result from alteration of biochemical substances. We aimed to investigate the effects of NBM lesions on the hippocampal interleukin-1beta (IL-1β), brain-derived neurotrophic factor (BDNF), and corticosterone levels, as inflammation markers, and hallmarks of neurodegeneration, stress, and metabolic status. Methods: Thirty-six male Wistar rats were randomly put in control, sham, and NBM-lesioned groups. After inducing the lesion using an intra-NBM injection of 10 µg ibotenic acid (5 µg/µL, each side) in rats, memory was estimated using the passive avoidance test. Moreover, serum and hippocampal IL-1β levels, as well as the hippocampal corticosterone, BDNF, and glucose levels were measured after 42 days. Results: Findings indicated a significant impairment of retention at different intervals in the NBM-lesioned group. BDNF decreased whereas corticosterone, glucose, and IL-1β levels increased in the hippocampus. Also, the levels of serum IL-1β, hippocampal BDNF, corticosterone, and glucose had significant correlations with hippocampal IL-1β levels. Conclusion: The synchronous alterations of some hippocampal factors, including BDNF, corticosterone, IL-1β, and glucose, caused by NBM lesion suggest that their interaction might play a significant role in neurodegeneration and relevant learning and memory impairments.
format	article
author	Nasrin Hosseini Maryam Radahmadi Hojjatollah Alaei Shabnam Nadjafi
author_facet	Nasrin Hosseini Maryam Radahmadi Hojjatollah Alaei Shabnam Nadjafi
author_sort	Nasrin Hosseini
title	Effect of Nucleus Basalis Magnocellularis Lesions on Memory and Hippocampal Brain-Derived Neurotrophic Factor, IL-1β, Glucose, and Corticosterone Levels in Adult Rats
title_short	Effect of Nucleus Basalis Magnocellularis Lesions on Memory and Hippocampal Brain-Derived Neurotrophic Factor, IL-1β, Glucose, and Corticosterone Levels in Adult Rats
title_full	Effect of Nucleus Basalis Magnocellularis Lesions on Memory and Hippocampal Brain-Derived Neurotrophic Factor, IL-1β, Glucose, and Corticosterone Levels in Adult Rats
title_fullStr	Effect of Nucleus Basalis Magnocellularis Lesions on Memory and Hippocampal Brain-Derived Neurotrophic Factor, IL-1β, Glucose, and Corticosterone Levels in Adult Rats
title_full_unstemmed	Effect of Nucleus Basalis Magnocellularis Lesions on Memory and Hippocampal Brain-Derived Neurotrophic Factor, IL-1β, Glucose, and Corticosterone Levels in Adult Rats
title_sort	effect of nucleus basalis magnocellularis lesions on memory and hippocampal brain-derived neurotrophic factor, il-1β, glucose, and corticosterone levels in adult rats
publisher	Shahid Beheshti University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/5ad475fd71cd432688e0c68bbce96d4e
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Effect of Nucleus Basalis Magnocellularis Lesions on Memory and Hippocampal Brain-Derived Neurotrophic Factor, IL-1β, Glucose, and Corticosterone Levels in Adult Rats

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