T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors

There is an urgent need to discover blood-based biomarkers to predict response to immune checkpoint inhibitors (ICI). Here the authors show that effective ICI therapy correlates with increased frequency of circulating CX3CR1+CD8+ T cells in preclinical tumor models and in a cohort of patients with n...

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Autores principales:	Takayoshi Yamauchi, Toshifumi Hoki, Takaaki Oba, Vaibhav Jain, Hongbin Chen, Kristopher Attwood, Sebastiano Battaglia, Saby George, Gurkamal Chatta, Igor Puzanov, Carl Morrison, Kunle Odunsi, Brahm H. Segal, Grace K. Dy, Marc S. Ernstoff, Fumito Ito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ad9763c2d134ba4b389bb215a94772a
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spelling	oai:doaj.org-article:5ad9763c2d134ba4b389bb215a94772a2021-12-02T13:35:00ZT-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors10.1038/s41467-021-21619-02041-1723https://doaj.org/article/5ad9763c2d134ba4b389bb215a94772a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21619-0https://doaj.org/toc/2041-1723There is an urgent need to discover blood-based biomarkers to predict response to immune checkpoint inhibitors (ICI). Here the authors show that effective ICI therapy correlates with increased frequency of circulating CX3CR1+CD8+ T cells in preclinical tumor models and in a cohort of patients with non-small cell lung cancer treated with anti-PD-1.Takayoshi YamauchiToshifumi HokiTakaaki ObaVaibhav JainHongbin ChenKristopher AttwoodSebastiano BattagliaSaby GeorgeGurkamal ChattaIgor PuzanovCarl MorrisonKunle OdunsiBrahm H. SegalGrace K. DyMarc S. ErnstoffFumito ItoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takayoshi Yamauchi Toshifumi Hoki Takaaki Oba Vaibhav Jain Hongbin Chen Kristopher Attwood Sebastiano Battaglia Saby George Gurkamal Chatta Igor Puzanov Carl Morrison Kunle Odunsi Brahm H. Segal Grace K. Dy Marc S. Ernstoff Fumito Ito T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors
description	There is an urgent need to discover blood-based biomarkers to predict response to immune checkpoint inhibitors (ICI). Here the authors show that effective ICI therapy correlates with increased frequency of circulating CX3CR1+CD8+ T cells in preclinical tumor models and in a cohort of patients with non-small cell lung cancer treated with anti-PD-1.
format	article
author	Takayoshi Yamauchi Toshifumi Hoki Takaaki Oba Vaibhav Jain Hongbin Chen Kristopher Attwood Sebastiano Battaglia Saby George Gurkamal Chatta Igor Puzanov Carl Morrison Kunle Odunsi Brahm H. Segal Grace K. Dy Marc S. Ernstoff Fumito Ito
author_facet	Takayoshi Yamauchi Toshifumi Hoki Takaaki Oba Vaibhav Jain Hongbin Chen Kristopher Attwood Sebastiano Battaglia Saby George Gurkamal Chatta Igor Puzanov Carl Morrison Kunle Odunsi Brahm H. Segal Grace K. Dy Marc S. Ernstoff Fumito Ito
author_sort	Takayoshi Yamauchi
title	T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors
title_short	T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors
title_full	T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors
title_fullStr	T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors
title_full_unstemmed	T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors
title_sort	t-cell cx3cr1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5ad9763c2d134ba4b389bb215a94772a
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T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors

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