γδ T cells control humoral immune response by inducing T follicular helper cell differentiation

Many immune functions have been reported for γδ T cells, including the regulation of antibody responses. Here the authors show that CXCR5+ γδ T cells release Wnt ligands to initiate the T follicular helper cell differentiation program and promote antibody production.

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Autores principales:	Rafael M. Rezende, Amanda J. Lanser, Stephen Rubino, Chantal Kuhn, Nathaniel Skillin, Thais G. Moreira, Shirong Liu, Galina Gabriely, Bruna A. David, Gustavo B. Menezes, Howard L. Weiner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5adbc105176d41f49ebebc1453323bb6
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spelling	oai:doaj.org-article:5adbc105176d41f49ebebc1453323bb62021-12-02T16:50:08Zγδ T cells control humoral immune response by inducing T follicular helper cell differentiation10.1038/s41467-018-05487-92041-1723https://doaj.org/article/5adbc105176d41f49ebebc1453323bb62018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05487-9https://doaj.org/toc/2041-1723Many immune functions have been reported for γδ T cells, including the regulation of antibody responses. Here the authors show that CXCR5+ γδ T cells release Wnt ligands to initiate the T follicular helper cell differentiation program and promote antibody production.Rafael M. RezendeAmanda J. LanserStephen RubinoChantal KuhnNathaniel SkillinThais G. MoreiraShirong LiuGalina GabrielyBruna A. DavidGustavo B. MenezesHoward L. WeinerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rafael M. Rezende Amanda J. Lanser Stephen Rubino Chantal Kuhn Nathaniel Skillin Thais G. Moreira Shirong Liu Galina Gabriely Bruna A. David Gustavo B. Menezes Howard L. Weiner γδ T cells control humoral immune response by inducing T follicular helper cell differentiation
description	Many immune functions have been reported for γδ T cells, including the regulation of antibody responses. Here the authors show that CXCR5+ γδ T cells release Wnt ligands to initiate the T follicular helper cell differentiation program and promote antibody production.
format	article
author	Rafael M. Rezende Amanda J. Lanser Stephen Rubino Chantal Kuhn Nathaniel Skillin Thais G. Moreira Shirong Liu Galina Gabriely Bruna A. David Gustavo B. Menezes Howard L. Weiner
author_facet	Rafael M. Rezende Amanda J. Lanser Stephen Rubino Chantal Kuhn Nathaniel Skillin Thais G. Moreira Shirong Liu Galina Gabriely Bruna A. David Gustavo B. Menezes Howard L. Weiner
author_sort	Rafael M. Rezende
title	γδ T cells control humoral immune response by inducing T follicular helper cell differentiation
title_short	γδ T cells control humoral immune response by inducing T follicular helper cell differentiation
title_full	γδ T cells control humoral immune response by inducing T follicular helper cell differentiation
title_fullStr	γδ T cells control humoral immune response by inducing T follicular helper cell differentiation
title_full_unstemmed	γδ T cells control humoral immune response by inducing T follicular helper cell differentiation
title_sort	γδ t cells control humoral immune response by inducing t follicular helper cell differentiation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5adbc105176d41f49ebebc1453323bb6
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γδ T cells control humoral immune response by inducing T follicular helper cell differentiation

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