The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions

Nakisa Soltani,1 Sayed Mohammad Marandi,1 Mohammad Kazemi,2 Nafiseh Esmaeil3 1Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran; 2Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran; 3Department of Immun...

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Autores principales:	Soltani N, Marandi SM, Kazemi M, Esmaeil N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	exercise training immune system adipose tissue toll-like receptors macrophage polarization obesity meta-inflammation Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/5ae05442d806464d8087eedfafdd2989
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spelling	oai:doaj.org-article:5ae05442d806464d8087eedfafdd29892021-12-02T08:39:31ZThe Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions1178-7007https://doaj.org/article/5ae05442d806464d8087eedfafdd29892020-03-01T00:00:00Zhttps://www.dovepress.com/the-exercise-training-modulatory-effects-on-the-obesity-induced-immuno-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Nakisa Soltani,1 Sayed Mohammad Marandi,1 Mohammad Kazemi,2 Nafiseh Esmaeil3 1Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran; 2Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran; 3Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranCorrespondence: Nafiseh EsmaeilDepartment of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan 81744-176, IranTel +98 31 37929097Fax +98 3113 7929031Email nafesm5@gmail.comSayed Mohammad MarandiDepartment of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, IranTel +983137932358Fax +983136687572Email smmarandi2001@yahoo.comAbstract: Reduced physical activity rate in people’s lifestyle is a global concern associated with the prevalence of health disorders such as obesity and metabolic disturbance. Ample evidence has indicated a critical role of the immune system in the aggravation of obesity. The type, duration, and production of adipose tissue-released mediators may change subsequent inactive lifestyle-induced obesity, leading to the chronic systematic inflammation and monocyte/macrophage (MON/MФ) phenotype polarization. Preliminary adipose tissue expansion can be inhibited by changing the lifestyle. In this context, exercise training is widely recommended due to a definite improvement of energy balance and the potential impacts on the inflammatory signaling cascades. How exercise training affects the immune system has not yet been fully elucidated, because its anti-inflammatory, pro-inflammatory, or even immunosuppressive impacts have been indicated in the literature. A thorough understanding of the mechanisms triggered by exercise can suggest a new approach to combat meta-inflammation-induced metabolic diseases. In this review, we summarized the obesity-induced inflammatory pathways, the roles of MON/MФ polarization in adipose tissue and systemic inflammation, and the underlying inflammatory mechanisms triggered by exercise during obesity.Keywords: exercise training, immune system, adipose tissue, toll-like receptors, macrophage polarization, obesity, meta-inflammationSoltani NMarandi SMKazemi MEsmaeil NDove Medical Pressarticleexercise trainingimmune systemadipose tissuetoll-like receptorsmacrophage polarizationobesitymeta-inflammationSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 785-810 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	exercise training immune system adipose tissue toll-like receptors macrophage polarization obesity meta-inflammation Specialties of internal medicine RC581-951
spellingShingle	exercise training immune system adipose tissue toll-like receptors macrophage polarization obesity meta-inflammation Specialties of internal medicine RC581-951 Soltani N Marandi SM Kazemi M Esmaeil N The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions
description	Nakisa Soltani,1 Sayed Mohammad Marandi,1 Mohammad Kazemi,2 Nafiseh Esmaeil3 1Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran; 2Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran; 3Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranCorrespondence: Nafiseh EsmaeilDepartment of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan 81744-176, IranTel +98 31 37929097Fax +98 3113 7929031Email nafesm5@gmail.comSayed Mohammad MarandiDepartment of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, IranTel +983137932358Fax +983136687572Email smmarandi2001@yahoo.comAbstract: Reduced physical activity rate in people’s lifestyle is a global concern associated with the prevalence of health disorders such as obesity and metabolic disturbance. Ample evidence has indicated a critical role of the immune system in the aggravation of obesity. The type, duration, and production of adipose tissue-released mediators may change subsequent inactive lifestyle-induced obesity, leading to the chronic systematic inflammation and monocyte/macrophage (MON/MФ) phenotype polarization. Preliminary adipose tissue expansion can be inhibited by changing the lifestyle. In this context, exercise training is widely recommended due to a definite improvement of energy balance and the potential impacts on the inflammatory signaling cascades. How exercise training affects the immune system has not yet been fully elucidated, because its anti-inflammatory, pro-inflammatory, or even immunosuppressive impacts have been indicated in the literature. A thorough understanding of the mechanisms triggered by exercise can suggest a new approach to combat meta-inflammation-induced metabolic diseases. In this review, we summarized the obesity-induced inflammatory pathways, the roles of MON/MФ polarization in adipose tissue and systemic inflammation, and the underlying inflammatory mechanisms triggered by exercise during obesity.Keywords: exercise training, immune system, adipose tissue, toll-like receptors, macrophage polarization, obesity, meta-inflammation
format	article
author	Soltani N Marandi SM Kazemi M Esmaeil N
author_facet	Soltani N Marandi SM Kazemi M Esmaeil N
author_sort	Soltani N
title	The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions
title_short	The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions
title_full	The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions
title_fullStr	The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions
title_full_unstemmed	The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions
title_sort	exercise training modulatory effects on the obesity-induced immunometabolic dysfunctions
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5ae05442d806464d8087eedfafdd2989
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The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions

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