Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo

Combining mouse hepatocyte progenitors and cholangiocytes ex vivo, the authors form an organoid that can drain bile ex vivo and transport metabolites, as in the liver.

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Autores principales:	Naoki Tanimizu, Norihisa Ichinohe, Yasushi Sasaki, Tohru Itoh, Ryo Sudo, Tomoko Yamaguchi, Takeshi Katsuda, Takafumi Ninomiya, Takashi Tokino, Takahiro Ochiya, Atsushi Miyajima, Toshihiro Mitaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ae34e70df8044cf9ed9cd6e6564d196
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spelling	oai:doaj.org-article:5ae34e70df8044cf9ed9cd6e6564d1962021-12-02T17:52:37ZGeneration of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo10.1038/s41467-021-23575-12041-1723https://doaj.org/article/5ae34e70df8044cf9ed9cd6e6564d1962021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23575-1https://doaj.org/toc/2041-1723Combining mouse hepatocyte progenitors and cholangiocytes ex vivo, the authors form an organoid that can drain bile ex vivo and transport metabolites, as in the liver.Naoki TanimizuNorihisa IchinoheYasushi SasakiTohru ItohRyo SudoTomoko YamaguchiTakeshi KatsudaTakafumi NinomiyaTakashi TokinoTakahiro OchiyaAtsushi MiyajimaToshihiro MitakaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Naoki Tanimizu Norihisa Ichinohe Yasushi Sasaki Tohru Itoh Ryo Sudo Tomoko Yamaguchi Takeshi Katsuda Takafumi Ninomiya Takashi Tokino Takahiro Ochiya Atsushi Miyajima Toshihiro Mitaka Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo
description	Combining mouse hepatocyte progenitors and cholangiocytes ex vivo, the authors form an organoid that can drain bile ex vivo and transport metabolites, as in the liver.
format	article
author	Naoki Tanimizu Norihisa Ichinohe Yasushi Sasaki Tohru Itoh Ryo Sudo Tomoko Yamaguchi Takeshi Katsuda Takafumi Ninomiya Takashi Tokino Takahiro Ochiya Atsushi Miyajima Toshihiro Mitaka
author_facet	Naoki Tanimizu Norihisa Ichinohe Yasushi Sasaki Tohru Itoh Ryo Sudo Tomoko Yamaguchi Takeshi Katsuda Takafumi Ninomiya Takashi Tokino Takahiro Ochiya Atsushi Miyajima Toshihiro Mitaka
author_sort	Naoki Tanimizu
title	Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo
title_short	Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo
title_full	Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo
title_fullStr	Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo
title_full_unstemmed	Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo
title_sort	generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5ae34e70df8044cf9ed9cd6e6564d196
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Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo

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