Niosomes: A Strategy toward Prevention of Clinically Significant Drug Incompatibilities

Abstract Drug incompatibilities are considered as one of the most critical problems in intensive care units. In the current study, the ability of nanomaterials to prevent drug incompatibilities in clinical settings has been investigated. As a proof-of-concept, the ability of niosomes to prevent phys...

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Autores principales:	Hebatallah B. Mohamed, Sohair M. El-Shanawany, Mostafa A. Hamad, Mahmoud Elsabahy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5ae565b652fe4f5891ea905adc4c92a0
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spelling	oai:doaj.org-article:5ae565b652fe4f5891ea905adc4c92a02021-12-02T11:53:10ZNiosomes: A Strategy toward Prevention of Clinically Significant Drug Incompatibilities10.1038/s41598-017-06955-w2045-2322https://doaj.org/article/5ae565b652fe4f5891ea905adc4c92a02017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06955-whttps://doaj.org/toc/2045-2322Abstract Drug incompatibilities are considered as one of the most critical problems in intensive care units. In the current study, the ability of nanomaterials to prevent drug incompatibilities in clinical settings has been investigated. As a proof-of-concept, the ability of niosomes to prevent physical and chemical incompatibilities that occur upon mixing acyclovir and vancomycin during management of acute meningitis has been explored. Nanosized spherical particles loaded separately with either vancomycin or acyclovir, with high entrapment efficiency (ca. 46–56%), could be prepared, and sustained release of their entrapped cargoes have been demonstrated over time. We have shown that precipitation, degradation and loss of biological activity of drugs occurred upon mixing solutions of the free drugs. On the contrary, drugs loaded separately inside niosomal structures exhibited high stability, exceptional physical and chemical compatibilities for up to 48 h with complete preservation of the antimicrobial activity of vancomycin. This study opens a venue for a new spectrum of applications of nanomaterials in preventing clinically significant drug incompatibilities, aiming at the reduction of adverse reactions, cost and hospitalization period, and improvement of patient compliance and therapeutic outcomes.Hebatallah B. MohamedSohair M. El-ShanawanyMostafa A. HamadMahmoud ElsabahyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hebatallah B. Mohamed Sohair M. El-Shanawany Mostafa A. Hamad Mahmoud Elsabahy Niosomes: A Strategy toward Prevention of Clinically Significant Drug Incompatibilities
description	Abstract Drug incompatibilities are considered as one of the most critical problems in intensive care units. In the current study, the ability of nanomaterials to prevent drug incompatibilities in clinical settings has been investigated. As a proof-of-concept, the ability of niosomes to prevent physical and chemical incompatibilities that occur upon mixing acyclovir and vancomycin during management of acute meningitis has been explored. Nanosized spherical particles loaded separately with either vancomycin or acyclovir, with high entrapment efficiency (ca. 46–56%), could be prepared, and sustained release of their entrapped cargoes have been demonstrated over time. We have shown that precipitation, degradation and loss of biological activity of drugs occurred upon mixing solutions of the free drugs. On the contrary, drugs loaded separately inside niosomal structures exhibited high stability, exceptional physical and chemical compatibilities for up to 48 h with complete preservation of the antimicrobial activity of vancomycin. This study opens a venue for a new spectrum of applications of nanomaterials in preventing clinically significant drug incompatibilities, aiming at the reduction of adverse reactions, cost and hospitalization period, and improvement of patient compliance and therapeutic outcomes.
format	article
author	Hebatallah B. Mohamed Sohair M. El-Shanawany Mostafa A. Hamad Mahmoud Elsabahy
author_facet	Hebatallah B. Mohamed Sohair M. El-Shanawany Mostafa A. Hamad Mahmoud Elsabahy
author_sort	Hebatallah B. Mohamed
title	Niosomes: A Strategy toward Prevention of Clinically Significant Drug Incompatibilities
title_short	Niosomes: A Strategy toward Prevention of Clinically Significant Drug Incompatibilities
title_full	Niosomes: A Strategy toward Prevention of Clinically Significant Drug Incompatibilities
title_fullStr	Niosomes: A Strategy toward Prevention of Clinically Significant Drug Incompatibilities
title_full_unstemmed	Niosomes: A Strategy toward Prevention of Clinically Significant Drug Incompatibilities
title_sort	niosomes: a strategy toward prevention of clinically significant drug incompatibilities
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5ae565b652fe4f5891ea905adc4c92a0
work_keys_str_mv	AT hebatallahbmohamed niosomesastrategytowardpreventionofclinicallysignificantdrugincompatibilities AT sohairmelshanawany niosomesastrategytowardpreventionofclinicallysignificantdrugincompatibilities AT mostafaahamad niosomesastrategytowardpreventionofclinicallysignificantdrugincompatibilities AT mahmoudelsabahy niosomesastrategytowardpreventionofclinicallysignificantdrugincompatibilities
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Niosomes: A Strategy toward Prevention of Clinically Significant Drug Incompatibilities

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