The origin of behavioral bursts in decision-making circuitry.

From ants to humans, the timing of many animal behaviors comes in bursts of activity separated by long periods of inactivity. Recently, mathematical modeling has shown that simple algorithms of priority-driven behavioral choice can result in bursty behavior. To experimentally test this link between...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Amanda Sorribes, Beatriz G Armendariz, Diego Lopez-Pigozzi, Cristina Murga, Gonzalo G de Polavieja
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5aece79fc73c4d9dbbee40c4d1669afd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5aece79fc73c4d9dbbee40c4d1669afd
record_format	dspace
spelling	oai:doaj.org-article:5aece79fc73c4d9dbbee40c4d1669afd2021-11-18T05:50:28ZThe origin of behavioral bursts in decision-making circuitry.1553-734X1553-735810.1371/journal.pcbi.1002075https://doaj.org/article/5aece79fc73c4d9dbbee40c4d1669afd2011-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21731478/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358From ants to humans, the timing of many animal behaviors comes in bursts of activity separated by long periods of inactivity. Recently, mathematical modeling has shown that simple algorithms of priority-driven behavioral choice can result in bursty behavior. To experimentally test this link between decision-making circuitry and bursty dynamics, we have turned to Drosophila melanogaster. We have found that the statistics of intervals between activity periods in endogenous activity-rest switches of wild-type Drosophila are very well described by the Weibull distribution, a common distribution of bursty dynamics in complex systems. The bursty dynamics of wild-type Drosophila walking activity are shown to be determined by this inter-event distribution alone and not by memory effects, thus resembling human dynamics. Further, using mutant flies that disrupt dopaminergic signaling or the mushroom body, circuitry implicated in decision-making, we show that the degree of behavioral burstiness can be modified. These results are thus consistent with the proposed link between decision-making circuitry and bursty dynamics, and highlight the importance of using simple experimental systems to test general theoretical models of behavior. The findings further suggest that analysis of bursts could prove useful for the study and evaluation of decision-making circuitry.Amanda SorribesBeatriz G ArmendarizDiego Lopez-PigozziCristina MurgaGonzalo G de PolaviejaPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 7, Iss 6, p e1002075 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Amanda Sorribes Beatriz G Armendariz Diego Lopez-Pigozzi Cristina Murga Gonzalo G de Polavieja The origin of behavioral bursts in decision-making circuitry.
description	From ants to humans, the timing of many animal behaviors comes in bursts of activity separated by long periods of inactivity. Recently, mathematical modeling has shown that simple algorithms of priority-driven behavioral choice can result in bursty behavior. To experimentally test this link between decision-making circuitry and bursty dynamics, we have turned to Drosophila melanogaster. We have found that the statistics of intervals between activity periods in endogenous activity-rest switches of wild-type Drosophila are very well described by the Weibull distribution, a common distribution of bursty dynamics in complex systems. The bursty dynamics of wild-type Drosophila walking activity are shown to be determined by this inter-event distribution alone and not by memory effects, thus resembling human dynamics. Further, using mutant flies that disrupt dopaminergic signaling or the mushroom body, circuitry implicated in decision-making, we show that the degree of behavioral burstiness can be modified. These results are thus consistent with the proposed link between decision-making circuitry and bursty dynamics, and highlight the importance of using simple experimental systems to test general theoretical models of behavior. The findings further suggest that analysis of bursts could prove useful for the study and evaluation of decision-making circuitry.
format	article
author	Amanda Sorribes Beatriz G Armendariz Diego Lopez-Pigozzi Cristina Murga Gonzalo G de Polavieja
author_facet	Amanda Sorribes Beatriz G Armendariz Diego Lopez-Pigozzi Cristina Murga Gonzalo G de Polavieja
author_sort	Amanda Sorribes
title	The origin of behavioral bursts in decision-making circuitry.
title_short	The origin of behavioral bursts in decision-making circuitry.
title_full	The origin of behavioral bursts in decision-making circuitry.
title_fullStr	The origin of behavioral bursts in decision-making circuitry.
title_full_unstemmed	The origin of behavioral bursts in decision-making circuitry.
title_sort	origin of behavioral bursts in decision-making circuitry.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/5aece79fc73c4d9dbbee40c4d1669afd
work_keys_str_mv	AT amandasorribes theoriginofbehavioralburstsindecisionmakingcircuitry AT beatrizgarmendariz theoriginofbehavioralburstsindecisionmakingcircuitry AT diegolopezpigozzi theoriginofbehavioralburstsindecisionmakingcircuitry AT cristinamurga theoriginofbehavioralburstsindecisionmakingcircuitry AT gonzalogdepolavieja theoriginofbehavioralburstsindecisionmakingcircuitry AT amandasorribes originofbehavioralburstsindecisionmakingcircuitry AT beatrizgarmendariz originofbehavioralburstsindecisionmakingcircuitry AT diegolopezpigozzi originofbehavioralburstsindecisionmakingcircuitry AT cristinamurga originofbehavioralburstsindecisionmakingcircuitry AT gonzalogdepolavieja originofbehavioralburstsindecisionmakingcircuitry
_version_	1718424787662929920

The origin of behavioral bursts in decision-making circuitry.

Ejemplares similares