Sedentary time and markers of chronic low-grade inflammation in a high risk population.

<h4>Background</h4>Sedentary behaviour has been identified as a distinct risk factor for several health outcomes. Nevertheless, little research has been conducted into the underlying mechanisms driving these observations. This study aimed to investigate the association of objectively mea...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Joseph Henson, Thomas Yates, Charlotte L Edwardson, Kamlesh Khunti, Duncan Talbot, Laura J Gray, Thomas M Leigh, Patrice Carter, Melanie J Davies
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5af182a06e6847cca79e512c4be32559
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5af182a06e6847cca79e512c4be32559
record_format	dspace
spelling	oai:doaj.org-article:5af182a06e6847cca79e512c4be325592021-11-18T08:49:06ZSedentary time and markers of chronic low-grade inflammation in a high risk population.1932-620310.1371/journal.pone.0078350https://doaj.org/article/5af182a06e6847cca79e512c4be325592013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24205208/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Sedentary behaviour has been identified as a distinct risk factor for several health outcomes. Nevertheless, little research has been conducted into the underlying mechanisms driving these observations. This study aimed to investigate the association of objectively measured sedentary time and breaks in sedentary time with markers of chronic low-grade inflammation and adiposity in a population at a high risk of type 2 diabetes mellitus.<h4>Methods</h4>This study reports data from an ongoing diabetes prevention programme conducted in Leicestershire, UK. High risk individuals were recruited from 10 primary care practices. Sedentary time (<25 counts per 15 s) was measured using Actigraph GT3X accelerometers (15 s epochs). A break was considered as any interruption in sedentary time (≥25 counts per 15 s). Biochemical outcomes included interleukin-6 (IL-6), C-reactive protein (CRP), leptin, adiponectin and leptin:adiponectin ratio (LAR). A sensitivity analysis investigated whether results were affected by removing participants with a CRP level >10 mg/L, as this can be indicative of acute inflammation.<h4>Results</h4>558 participants (age = 63.6±7.7 years; male = 64.7%) had complete adipokine and accelerometer data. Following adjustment for various confounders, sedentary time was detrimentally associated with CRP (β = 0.176±0.057, p = 0.002), IL-6 (β = 0.242±0.056, p = <0.001), leptin (β = 0.146±0.043, p = <0.001) and LAR (β = 0.208±0.052, p = <0.001). Associations were attenuated after further adjustment for moderate-to-vigorous physical activity (MVPA) with only IL-6 (β = 0.231±0.073, p = 0.002) remaining significant; this result was unaffected after further adjustment for body mass index and glycosylated haemoglobin (HbA1c). Similarly, breaks in sedentary time were significantly inversely associated with IL-6 (β = -0.094±0.047, p = 0.045) and leptin (β = -0.075±0.037, p = 0.039); however, these associations were attenuated after adjustment for accelerometer derived variables. Excluding individuals with a CRP level >10 mg/L consistently attenuated the significant associations across all markers of inflammation.<h4>Conclusion</h4>These novel findings from a high risk population recruited through primary care suggest that sedentary behaviour may influence markers associated with inflammation, independent of MVPA, glycaemia and adiposity.Joseph HensonThomas YatesCharlotte L EdwardsonKamlesh KhuntiDuncan TalbotLaura J GrayThomas M LeighPatrice CarterMelanie J DaviesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e78350 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joseph Henson Thomas Yates Charlotte L Edwardson Kamlesh Khunti Duncan Talbot Laura J Gray Thomas M Leigh Patrice Carter Melanie J Davies Sedentary time and markers of chronic low-grade inflammation in a high risk population.
description	<h4>Background</h4>Sedentary behaviour has been identified as a distinct risk factor for several health outcomes. Nevertheless, little research has been conducted into the underlying mechanisms driving these observations. This study aimed to investigate the association of objectively measured sedentary time and breaks in sedentary time with markers of chronic low-grade inflammation and adiposity in a population at a high risk of type 2 diabetes mellitus.<h4>Methods</h4>This study reports data from an ongoing diabetes prevention programme conducted in Leicestershire, UK. High risk individuals were recruited from 10 primary care practices. Sedentary time (<25 counts per 15 s) was measured using Actigraph GT3X accelerometers (15 s epochs). A break was considered as any interruption in sedentary time (≥25 counts per 15 s). Biochemical outcomes included interleukin-6 (IL-6), C-reactive protein (CRP), leptin, adiponectin and leptin:adiponectin ratio (LAR). A sensitivity analysis investigated whether results were affected by removing participants with a CRP level >10 mg/L, as this can be indicative of acute inflammation.<h4>Results</h4>558 participants (age = 63.6±7.7 years; male = 64.7%) had complete adipokine and accelerometer data. Following adjustment for various confounders, sedentary time was detrimentally associated with CRP (β = 0.176±0.057, p = 0.002), IL-6 (β = 0.242±0.056, p = <0.001), leptin (β = 0.146±0.043, p = <0.001) and LAR (β = 0.208±0.052, p = <0.001). Associations were attenuated after further adjustment for moderate-to-vigorous physical activity (MVPA) with only IL-6 (β = 0.231±0.073, p = 0.002) remaining significant; this result was unaffected after further adjustment for body mass index and glycosylated haemoglobin (HbA1c). Similarly, breaks in sedentary time were significantly inversely associated with IL-6 (β = -0.094±0.047, p = 0.045) and leptin (β = -0.075±0.037, p = 0.039); however, these associations were attenuated after adjustment for accelerometer derived variables. Excluding individuals with a CRP level >10 mg/L consistently attenuated the significant associations across all markers of inflammation.<h4>Conclusion</h4>These novel findings from a high risk population recruited through primary care suggest that sedentary behaviour may influence markers associated with inflammation, independent of MVPA, glycaemia and adiposity.
format	article
author	Joseph Henson Thomas Yates Charlotte L Edwardson Kamlesh Khunti Duncan Talbot Laura J Gray Thomas M Leigh Patrice Carter Melanie J Davies
author_facet	Joseph Henson Thomas Yates Charlotte L Edwardson Kamlesh Khunti Duncan Talbot Laura J Gray Thomas M Leigh Patrice Carter Melanie J Davies
author_sort	Joseph Henson
title	Sedentary time and markers of chronic low-grade inflammation in a high risk population.
title_short	Sedentary time and markers of chronic low-grade inflammation in a high risk population.
title_full	Sedentary time and markers of chronic low-grade inflammation in a high risk population.
title_fullStr	Sedentary time and markers of chronic low-grade inflammation in a high risk population.
title_full_unstemmed	Sedentary time and markers of chronic low-grade inflammation in a high risk population.
title_sort	sedentary time and markers of chronic low-grade inflammation in a high risk population.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5af182a06e6847cca79e512c4be32559
work_keys_str_mv	AT josephhenson sedentarytimeandmarkersofchroniclowgradeinflammationinahighriskpopulation AT thomasyates sedentarytimeandmarkersofchroniclowgradeinflammationinahighriskpopulation AT charlotteledwardson sedentarytimeandmarkersofchroniclowgradeinflammationinahighriskpopulation AT kamleshkhunti sedentarytimeandmarkersofchroniclowgradeinflammationinahighriskpopulation AT duncantalbot sedentarytimeandmarkersofchroniclowgradeinflammationinahighriskpopulation AT laurajgray sedentarytimeandmarkersofchroniclowgradeinflammationinahighriskpopulation AT thomasmleigh sedentarytimeandmarkersofchroniclowgradeinflammationinahighriskpopulation AT patricecarter sedentarytimeandmarkersofchroniclowgradeinflammationinahighriskpopulation AT melaniejdavies sedentarytimeandmarkersofchroniclowgradeinflammationinahighriskpopulation
_version_	1718421263421014016

Sedentary time and markers of chronic low-grade inflammation in a high risk population.

Ejemplares similares