A satellite explosion in the genome of holocentric nematodes.

Centromere sequences in the genome are associated with the formation of kinetochores, where spindle microtubules grow in mitosis. Centromere sequences usually have long tandem repeats (satellites). In holocentric nematodes it is not clear how kinetochores are formed during mitosis; they are distribu...

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Autores principales:	Juan A Subirana, Xavier Messeguer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5af25b367f8b4ce9bf888a107d3d4a58
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spelling	oai:doaj.org-article:5af25b367f8b4ce9bf888a107d3d4a582021-11-18T07:47:59ZA satellite explosion in the genome of holocentric nematodes.1932-620310.1371/journal.pone.0062221https://doaj.org/article/5af25b367f8b4ce9bf888a107d3d4a582013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23638010/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Centromere sequences in the genome are associated with the formation of kinetochores, where spindle microtubules grow in mitosis. Centromere sequences usually have long tandem repeats (satellites). In holocentric nematodes it is not clear how kinetochores are formed during mitosis; they are distributed throughout the chromosomes. For this reason it appeared of interest to study the satellites in nematodes in order to determine if they offer any clue on how kinetochores are assembled in these species. We have studied the satellites in the genome of six nematode species. We found that the presence of satellites depends on whether the nematode chromosomes are holocentric or monocentric. It turns out that holocentric nematodes are unique because they have a large number of satellites scattered throughout their genome. Their number, length and composition are different in each species: they apparently have very little evolutionary conservation. In contrast, no scattered satellites are found in the monocentric nematode Trichinella spiralis. It appears that the absence/presence of scattered satellites in the genome distinguishes monocentric from holocentric nematodes. We conclude that the presence of satellites is related to the holocentric nature of the chromosomes of most nematodes. Satellites may stabilize a higher order structure of chromatin and facilitate the formation of kinetochores. We also present a new program, SATFIND, which is suited to find satellite sequences.Juan A SubiranaXavier MesseguerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e62221 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan A Subirana Xavier Messeguer A satellite explosion in the genome of holocentric nematodes.
description	Centromere sequences in the genome are associated with the formation of kinetochores, where spindle microtubules grow in mitosis. Centromere sequences usually have long tandem repeats (satellites). In holocentric nematodes it is not clear how kinetochores are formed during mitosis; they are distributed throughout the chromosomes. For this reason it appeared of interest to study the satellites in nematodes in order to determine if they offer any clue on how kinetochores are assembled in these species. We have studied the satellites in the genome of six nematode species. We found that the presence of satellites depends on whether the nematode chromosomes are holocentric or monocentric. It turns out that holocentric nematodes are unique because they have a large number of satellites scattered throughout their genome. Their number, length and composition are different in each species: they apparently have very little evolutionary conservation. In contrast, no scattered satellites are found in the monocentric nematode Trichinella spiralis. It appears that the absence/presence of scattered satellites in the genome distinguishes monocentric from holocentric nematodes. We conclude that the presence of satellites is related to the holocentric nature of the chromosomes of most nematodes. Satellites may stabilize a higher order structure of chromatin and facilitate the formation of kinetochores. We also present a new program, SATFIND, which is suited to find satellite sequences.
format	article
author	Juan A Subirana Xavier Messeguer
author_facet	Juan A Subirana Xavier Messeguer
author_sort	Juan A Subirana
title	A satellite explosion in the genome of holocentric nematodes.
title_short	A satellite explosion in the genome of holocentric nematodes.
title_full	A satellite explosion in the genome of holocentric nematodes.
title_fullStr	A satellite explosion in the genome of holocentric nematodes.
title_full_unstemmed	A satellite explosion in the genome of holocentric nematodes.
title_sort	satellite explosion in the genome of holocentric nematodes.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5af25b367f8b4ce9bf888a107d3d4a58
work_keys_str_mv	AT juanasubirana asatelliteexplosioninthegenomeofholocentricnematodes AT xaviermesseguer asatelliteexplosioninthegenomeofholocentricnematodes AT juanasubirana satelliteexplosioninthegenomeofholocentricnematodes AT xaviermesseguer satelliteexplosioninthegenomeofholocentricnematodes
_version_	1718422912039387136

A satellite explosion in the genome of holocentric nematodes.

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