Association of Circulating Irisin Levels with Adiposity and Glucose Metabolic Profiles in a Middle-Aged Chinese Population: A Cross-Sectional Study

Ruibin Zhang,1,* Tingting Fu,2,* Xin Zhao,3 Yao Qiu,4 Xiaolin Hu,5 Hongyan Shi,4 Xiao Yin5 1Department of Medicine, Shandong University Affiliated Jinan Central Hospital, Jinan, Shandong, People’s Republic of China; 2Department of Clinical Medicine, Qilu College of Medicine, Shandong Unive...

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Autores principales:	Zhang R, Fu T, Zhao X, Qiu Y, Hu X, Shi H, Yin X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	irisin obesity type 2 diabetes chinese Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/5af3f47796574d45965d2d8e9c9addd7
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spelling	oai:doaj.org-article:5af3f47796574d45965d2d8e9c9addd72021-12-02T10:43:11ZAssociation of Circulating Irisin Levels with Adiposity and Glucose Metabolic Profiles in a Middle-Aged Chinese Population: A Cross-Sectional Study1178-7007https://doaj.org/article/5af3f47796574d45965d2d8e9c9addd72020-10-01T00:00:00Zhttps://www.dovepress.com/association-of-circulating-irisin-levels-with-adiposity-and-glucose-me-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Ruibin Zhang,1,* Tingting Fu,2,* Xin Zhao,3 Yao Qiu,4 Xiaolin Hu,5 Hongyan Shi,4 Xiao Yin5 1Department of Medicine, Shandong University Affiliated Jinan Central Hospital, Jinan, Shandong, People’s Republic of China; 2Department of Clinical Medicine, Qilu College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 3Department of Clinical Laboratory, Shandong University Affiliated Jinan Central Hospital, Jinan, Shandong, People’s Republic of China; 4Department of Surgery, Shandong University Affiliated Jinan Central Hospital, Jinan, Shandong, People’s Republic of China; 5Department of Endocrinology and Metabolism, Shandong University Affiliated Jinan Central Hospital, Jinan, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao YinDepartment of Endocrinology and Metabolism, Shandong University Affiliated Jinan Central Hospital, Linong Road 8, 5-1-801, Jinan 250013, People’s Republic of ChinaTel +86-15318816220Email yinxiao@sdu.edu.cnObjective: The myokine irisin has been proposed to affect obesity and metabolism disorders. However, data about the association of irisin with obesity and glucose metabolic status in humans remains controversial, and limited data are available concerning the Chinese population. This study aimed to evaluate the association between serum irisin concentrations and obesity, as well as glucose metabolic and cardiovascular factors in the middle-aged physical activity-matched Chinese Han race population.Methods: A total of 740 participants were included in this cross-sectional study, who were divided into a normal weight (NW) group, overweight/obese (OB) group, normal weight type 2 diabetes (DM-NW) group and overweight/obese diabetes (DM-OB) group, and physical activity was evaluated and matched for the four groups. Circulating irisin levels were analyzed and compared among the groups with different adiposity and glucose status. Linear regression analysis was performed to test the relationship between serum irisin and adiposity indices, glucose metabolic and other cardiovascular risk factors.Results: Circulating irisin levels were significantly correlated with higher levels of direct and indirect adiposity markers, including BMI, waist circumference and fat mass, and other cardiovascular risk factors, such as plasma triglyceride and low-density lipoprotein cholesterol level (p < 0.01). Diabetes patients had lower irisin levels compared to non-diabetes participants, in either normal weight and obese group, resulting in a correlation of irisin with HbA1c, HOMA-IR and HOMA-IS (p < 0.01). Linear regression analysis demonstrated that irisin serum concentrations were independently associated with sex, BMI, HbA1c, HOMA-IR and HOMA-IS (R2 = 0.465).Conclusion: These data indicated that circulating irisin was affected by adiposity and glucose metabolism condition in the middle-aged Chinese population. The increase of irisin under conditions of obesity may indicate its physiological function to improve glucose tolerance which is often impaired in obese subjects, but this compensatory secretion of irisin seems likely to be progressing to a secretion failure once diabetes developed.Keywords: irisin, obesity, type 2 diabetes, ChineseZhang RFu TZhao XQiu YHu XShi HYin XDove Medical Pressarticleirisinobesitytype 2 diabeteschineseSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4105-4112 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	irisin obesity type 2 diabetes chinese Specialties of internal medicine RC581-951
spellingShingle	irisin obesity type 2 diabetes chinese Specialties of internal medicine RC581-951 Zhang R Fu T Zhao X Qiu Y Hu X Shi H Yin X Association of Circulating Irisin Levels with Adiposity and Glucose Metabolic Profiles in a Middle-Aged Chinese Population: A Cross-Sectional Study
description	Ruibin Zhang,1,* Tingting Fu,2,* Xin Zhao,3 Yao Qiu,4 Xiaolin Hu,5 Hongyan Shi,4 Xiao Yin5 1Department of Medicine, Shandong University Affiliated Jinan Central Hospital, Jinan, Shandong, People’s Republic of China; 2Department of Clinical Medicine, Qilu College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 3Department of Clinical Laboratory, Shandong University Affiliated Jinan Central Hospital, Jinan, Shandong, People’s Republic of China; 4Department of Surgery, Shandong University Affiliated Jinan Central Hospital, Jinan, Shandong, People’s Republic of China; 5Department of Endocrinology and Metabolism, Shandong University Affiliated Jinan Central Hospital, Jinan, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao YinDepartment of Endocrinology and Metabolism, Shandong University Affiliated Jinan Central Hospital, Linong Road 8, 5-1-801, Jinan 250013, People’s Republic of ChinaTel +86-15318816220Email yinxiao@sdu.edu.cnObjective: The myokine irisin has been proposed to affect obesity and metabolism disorders. However, data about the association of irisin with obesity and glucose metabolic status in humans remains controversial, and limited data are available concerning the Chinese population. This study aimed to evaluate the association between serum irisin concentrations and obesity, as well as glucose metabolic and cardiovascular factors in the middle-aged physical activity-matched Chinese Han race population.Methods: A total of 740 participants were included in this cross-sectional study, who were divided into a normal weight (NW) group, overweight/obese (OB) group, normal weight type 2 diabetes (DM-NW) group and overweight/obese diabetes (DM-OB) group, and physical activity was evaluated and matched for the four groups. Circulating irisin levels were analyzed and compared among the groups with different adiposity and glucose status. Linear regression analysis was performed to test the relationship between serum irisin and adiposity indices, glucose metabolic and other cardiovascular risk factors.Results: Circulating irisin levels were significantly correlated with higher levels of direct and indirect adiposity markers, including BMI, waist circumference and fat mass, and other cardiovascular risk factors, such as plasma triglyceride and low-density lipoprotein cholesterol level (p < 0.01). Diabetes patients had lower irisin levels compared to non-diabetes participants, in either normal weight and obese group, resulting in a correlation of irisin with HbA1c, HOMA-IR and HOMA-IS (p < 0.01). Linear regression analysis demonstrated that irisin serum concentrations were independently associated with sex, BMI, HbA1c, HOMA-IR and HOMA-IS (R2 = 0.465).Conclusion: These data indicated that circulating irisin was affected by adiposity and glucose metabolism condition in the middle-aged Chinese population. The increase of irisin under conditions of obesity may indicate its physiological function to improve glucose tolerance which is often impaired in obese subjects, but this compensatory secretion of irisin seems likely to be progressing to a secretion failure once diabetes developed.Keywords: irisin, obesity, type 2 diabetes, Chinese
format	article
author	Zhang R Fu T Zhao X Qiu Y Hu X Shi H Yin X
author_facet	Zhang R Fu T Zhao X Qiu Y Hu X Shi H Yin X
author_sort	Zhang R
title	Association of Circulating Irisin Levels with Adiposity and Glucose Metabolic Profiles in a Middle-Aged Chinese Population: A Cross-Sectional Study
title_short	Association of Circulating Irisin Levels with Adiposity and Glucose Metabolic Profiles in a Middle-Aged Chinese Population: A Cross-Sectional Study
title_full	Association of Circulating Irisin Levels with Adiposity and Glucose Metabolic Profiles in a Middle-Aged Chinese Population: A Cross-Sectional Study
title_fullStr	Association of Circulating Irisin Levels with Adiposity and Glucose Metabolic Profiles in a Middle-Aged Chinese Population: A Cross-Sectional Study
title_full_unstemmed	Association of Circulating Irisin Levels with Adiposity and Glucose Metabolic Profiles in a Middle-Aged Chinese Population: A Cross-Sectional Study
title_sort	association of circulating irisin levels with adiposity and glucose metabolic profiles in a middle-aged chinese population: a cross-sectional study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5af3f47796574d45965d2d8e9c9addd7
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Association of Circulating Irisin Levels with Adiposity and Glucose Metabolic Profiles in a Middle-Aged Chinese Population: A Cross-Sectional Study

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