Long-term changes in mandibular bone microchemical quality after radiation therapy and underlying systemic malignancy: A pilot study

Radiation therapy (RT) is a treatment option for head and neck cancer (HNC), but 2% of RT patients may experience damage to the jawbone, resulting in osteoradionecrosis (ORN). The ORN can manifest years after RT exposure. Changes in the local microchemical bone quality prior to the clinical manifest...

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Autores principales:	A. Palander, H. Dekker, M. Hyvärinen, L. Rieppo, I. Lyijynen, E. A. J. M. Schulten, C. M. Ten Bruggenkate, A. Koistinen, A. Kullaa, M. J. Turunen
Formato:	article
Lenguaje:	EN
Publicado:	World Scientific Publishing 2021
Materias:	mandibular bone radiation therapy fourier transform infrared spectroscopy Technology T Optics. Light QC350-467
Acceso en línea:	https://doaj.org/article/5af46adcddf44b95b8f15973736f015a
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spelling	oai:doaj.org-article:5af46adcddf44b95b8f15973736f015a2021-11-23T13:04:53ZLong-term changes in mandibular bone microchemical quality after radiation therapy and underlying systemic malignancy: A pilot study1793-54581793-720510.1142/S179354582150019Xhttps://doaj.org/article/5af46adcddf44b95b8f15973736f015a2021-11-01T00:00:00Zhttp://www.worldscientific.com/doi/epdf/10.1142/S179354582150019Xhttps://doaj.org/toc/1793-5458https://doaj.org/toc/1793-7205Radiation therapy (RT) is a treatment option for head and neck cancer (HNC), but 2% of RT patients may experience damage to the jawbone, resulting in osteoradionecrosis (ORN). The ORN can manifest years after RT exposure. Changes in the local microchemical bone quality prior to the clinical manifestation of ORN could play a key role in ORN pathogenesis. Chemical bone quality can be analyzed using Fourier transform infrared spectroscopy (FTIR), that is applied to examine the effects of cancer, chemotherapy, and RT on the quality of human mandibular bone. Cortical mandibular bone samples were harvested from dental implant beds of 23 individuals, i.e., patients with surgically and radiotherapeutically treated HNC (RT-HNC, n=7), surgically and radiochemotherapeutically treated HNC (CH-RT-HNC, n=3), only surgically treated HNC (SRG-HNC, n=4), and healthy controls (n=9). Infrared spectra were acquired from two representative regions of interest in cortical mandibular bone. Spectral parameters, i.e., mineral-to-matrix ratio (MM), carbonate-to-matrix ratio (CM), carbonate-to-phosphate ratio (CP), collagen maturity (cross-linking), crystallinity, acid phosphate substitution (APS), and advanced glycation end products (AGEs), were analyzed for each sample. Amide I region of the CH-RT-HNC group differed from the control group in cluster analysis (p=0.02). Apart from a minor variation trend in collagen maturity (p=0.07), there were no other significant differences between the groups. Thus, the effect of radiochemotherapy on mandibular bone composition should be further investigated. In future trials, this study design is potential when the effects of the cancer burden and different HNC treatment modalities on jawbone composition are studied, in order to reveal ORN pathogenesis.A. PalanderH. DekkerM. HyvärinenL. RieppoI. LyijynenE. A. J. M. SchultenC. M. Ten BruggenkateA. KoistinenA. KullaaM. J. TurunenWorld Scientific Publishingarticlemandibular boneradiation therapyfourier transform infrared spectroscopyTechnologyTOptics. LightQC350-467ENJournal of Innovative Optical Health Sciences, Vol 14, Iss 6, Pp 2150019-1-2150019-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mandibular bone radiation therapy fourier transform infrared spectroscopy Technology T Optics. Light QC350-467
spellingShingle	mandibular bone radiation therapy fourier transform infrared spectroscopy Technology T Optics. Light QC350-467 A. Palander H. Dekker M. Hyvärinen L. Rieppo I. Lyijynen E. A. J. M. Schulten C. M. Ten Bruggenkate A. Koistinen A. Kullaa M. J. Turunen Long-term changes in mandibular bone microchemical quality after radiation therapy and underlying systemic malignancy: A pilot study
description	Radiation therapy (RT) is a treatment option for head and neck cancer (HNC), but 2% of RT patients may experience damage to the jawbone, resulting in osteoradionecrosis (ORN). The ORN can manifest years after RT exposure. Changes in the local microchemical bone quality prior to the clinical manifestation of ORN could play a key role in ORN pathogenesis. Chemical bone quality can be analyzed using Fourier transform infrared spectroscopy (FTIR), that is applied to examine the effects of cancer, chemotherapy, and RT on the quality of human mandibular bone. Cortical mandibular bone samples were harvested from dental implant beds of 23 individuals, i.e., patients with surgically and radiotherapeutically treated HNC (RT-HNC, n=7), surgically and radiochemotherapeutically treated HNC (CH-RT-HNC, n=3), only surgically treated HNC (SRG-HNC, n=4), and healthy controls (n=9). Infrared spectra were acquired from two representative regions of interest in cortical mandibular bone. Spectral parameters, i.e., mineral-to-matrix ratio (MM), carbonate-to-matrix ratio (CM), carbonate-to-phosphate ratio (CP), collagen maturity (cross-linking), crystallinity, acid phosphate substitution (APS), and advanced glycation end products (AGEs), were analyzed for each sample. Amide I region of the CH-RT-HNC group differed from the control group in cluster analysis (p=0.02). Apart from a minor variation trend in collagen maturity (p=0.07), there were no other significant differences between the groups. Thus, the effect of radiochemotherapy on mandibular bone composition should be further investigated. In future trials, this study design is potential when the effects of the cancer burden and different HNC treatment modalities on jawbone composition are studied, in order to reveal ORN pathogenesis.
format	article
author	A. Palander H. Dekker M. Hyvärinen L. Rieppo I. Lyijynen E. A. J. M. Schulten C. M. Ten Bruggenkate A. Koistinen A. Kullaa M. J. Turunen
author_facet	A. Palander H. Dekker M. Hyvärinen L. Rieppo I. Lyijynen E. A. J. M. Schulten C. M. Ten Bruggenkate A. Koistinen A. Kullaa M. J. Turunen
author_sort	A. Palander
title	Long-term changes in mandibular bone microchemical quality after radiation therapy and underlying systemic malignancy: A pilot study
title_short	Long-term changes in mandibular bone microchemical quality after radiation therapy and underlying systemic malignancy: A pilot study
title_full	Long-term changes in mandibular bone microchemical quality after radiation therapy and underlying systemic malignancy: A pilot study
title_fullStr	Long-term changes in mandibular bone microchemical quality after radiation therapy and underlying systemic malignancy: A pilot study
title_full_unstemmed	Long-term changes in mandibular bone microchemical quality after radiation therapy and underlying systemic malignancy: A pilot study
title_sort	long-term changes in mandibular bone microchemical quality after radiation therapy and underlying systemic malignancy: a pilot study
publisher	World Scientific Publishing
publishDate	2021
url	https://doaj.org/article/5af46adcddf44b95b8f15973736f015a
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Long-term changes in mandibular bone microchemical quality after radiation therapy and underlying systemic malignancy: A pilot study

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