Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

Intervertebral disk degeneration (IDD) is characterized by changes in the nucleus pulposus (NP) extra cellular matrix that compromise disk structural integrity. In a miRNA screen of human IDD patient NP tissue, the authors identify deregulated miR-141 and show that direct injection of nanoparticle-c...

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Autores principales: Ming-liang Ji, Hua Jiang, Xue-jun Zhang, Pei-liang Shi, Chao Li, Hao Wu, Xiao-tao Wu, Yun-tao Wang, Chen Wang, Jun Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5af4fa98c3074207be1a611a2bff2f4b
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spelling oai:doaj.org-article:5af4fa98c3074207be1a611a2bff2f4b2021-12-02T15:34:15ZPreclinical development of a microRNA-based therapy for intervertebral disc degeneration10.1038/s41467-018-07360-12041-1723https://doaj.org/article/5af4fa98c3074207be1a611a2bff2f4b2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07360-1https://doaj.org/toc/2041-1723Intervertebral disk degeneration (IDD) is characterized by changes in the nucleus pulposus (NP) extra cellular matrix that compromise disk structural integrity. In a miRNA screen of human IDD patient NP tissue, the authors identify deregulated miR-141 and show that direct injection of nanoparticle-coupled miR-141 into the NP alleviates IDD in mice.Ming-liang JiHua JiangXue-jun ZhangPei-liang ShiChao LiHao WuXiao-tao WuYun-tao WangChen WangJun LuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ming-liang Ji
Hua Jiang
Xue-jun Zhang
Pei-liang Shi
Chao Li
Hao Wu
Xiao-tao Wu
Yun-tao Wang
Chen Wang
Jun Lu
Preclinical development of a microRNA-based therapy for intervertebral disc degeneration
description Intervertebral disk degeneration (IDD) is characterized by changes in the nucleus pulposus (NP) extra cellular matrix that compromise disk structural integrity. In a miRNA screen of human IDD patient NP tissue, the authors identify deregulated miR-141 and show that direct injection of nanoparticle-coupled miR-141 into the NP alleviates IDD in mice.
format article
author Ming-liang Ji
Hua Jiang
Xue-jun Zhang
Pei-liang Shi
Chao Li
Hao Wu
Xiao-tao Wu
Yun-tao Wang
Chen Wang
Jun Lu
author_facet Ming-liang Ji
Hua Jiang
Xue-jun Zhang
Pei-liang Shi
Chao Li
Hao Wu
Xiao-tao Wu
Yun-tao Wang
Chen Wang
Jun Lu
author_sort Ming-liang Ji
title Preclinical development of a microRNA-based therapy for intervertebral disc degeneration
title_short Preclinical development of a microRNA-based therapy for intervertebral disc degeneration
title_full Preclinical development of a microRNA-based therapy for intervertebral disc degeneration
title_fullStr Preclinical development of a microRNA-based therapy for intervertebral disc degeneration
title_full_unstemmed Preclinical development of a microRNA-based therapy for intervertebral disc degeneration
title_sort preclinical development of a microrna-based therapy for intervertebral disc degeneration
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/5af4fa98c3074207be1a611a2bff2f4b
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AT xuejunzhang preclinicaldevelopmentofamicrornabasedtherapyforintervertebraldiscdegeneration
AT peiliangshi preclinicaldevelopmentofamicrornabasedtherapyforintervertebraldiscdegeneration
AT chaoli preclinicaldevelopmentofamicrornabasedtherapyforintervertebraldiscdegeneration
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AT yuntaowang preclinicaldevelopmentofamicrornabasedtherapyforintervertebraldiscdegeneration
AT chenwang preclinicaldevelopmentofamicrornabasedtherapyforintervertebraldiscdegeneration
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