Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

Preclinical development of a microRNA-based therapy for intervertebral disc degeneration

Intervertebral disk degeneration (IDD) is characterized by changes in the nucleus pulposus (NP) extra cellular matrix that compromise disk structural integrity. In a miRNA screen of human IDD patient NP tissue, the authors identify deregulated miR-141 and show that direct injection of nanoparticle-c...

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Autores principales: Ming-liang Ji, Hua Jiang, Xue-jun Zhang, Pei-liang Shi, Chao Li, Hao Wu, Xiao-tao Wu, Yun-tao Wang, Chen Wang, Jun Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/5af4fa98c3074207be1a611a2bff2f4b
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