FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation

Genetic ablation of Mitochondrial Ca2+ uptake protein 1 (MICU1) in mouse induces higher rates of perinatal lethality. Here the authors show that MICU1 expression is regulated by hypoxia in a FOXD1-dependent manner, establishing a cyclic switch between glycolytic and oxidative metabolism during devel...

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Autores principales:	Santhanam Shanmughapriya, Dhanendra Tomar, Zhiwei Dong, Katherine J. Slovik, Neeharika Nemani, Kalimuthusamy Natarajaseenivasan, Edmund Carvalho, Christy Lu, Kaitlyn Corrigan, Venkata Naga Srikanth Garikipati, Jessica Ibetti, Sudarsan Rajan, Carlos Barrero, Kurt Chuprun, Raj Kishore, Salim Merali, Ying Tian, Wenli Yang, Muniswamy Madesh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5af6e51c9e9c49309cc33ce6b1c415cc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:5af6e51c9e9c49309cc33ce6b1c415cc2021-12-02T16:50:12ZFOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation10.1038/s41467-018-05856-42041-1723https://doaj.org/article/5af6e51c9e9c49309cc33ce6b1c415cc2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05856-4https://doaj.org/toc/2041-1723Genetic ablation of Mitochondrial Ca2+ uptake protein 1 (MICU1) in mouse induces higher rates of perinatal lethality. Here the authors show that MICU1 expression is regulated by hypoxia in a FOXD1-dependent manner, establishing a cyclic switch between glycolytic and oxidative metabolism during development.Santhanam ShanmughapriyaDhanendra TomarZhiwei DongKatherine J. SlovikNeeharika NemaniKalimuthusamy NatarajaseenivasanEdmund CarvalhoChristy LuKaitlyn CorriganVenkata Naga Srikanth GarikipatiJessica IbettiSudarsan RajanCarlos BarreroKurt ChuprunRaj KishoreSalim MeraliYing TianWenli YangMuniswamy MadeshNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Santhanam Shanmughapriya Dhanendra Tomar Zhiwei Dong Katherine J. Slovik Neeharika Nemani Kalimuthusamy Natarajaseenivasan Edmund Carvalho Christy Lu Kaitlyn Corrigan Venkata Naga Srikanth Garikipati Jessica Ibetti Sudarsan Rajan Carlos Barrero Kurt Chuprun Raj Kishore Salim Merali Ying Tian Wenli Yang Muniswamy Madesh FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
description	Genetic ablation of Mitochondrial Ca2+ uptake protein 1 (MICU1) in mouse induces higher rates of perinatal lethality. Here the authors show that MICU1 expression is regulated by hypoxia in a FOXD1-dependent manner, establishing a cyclic switch between glycolytic and oxidative metabolism during development.
format	article
author	Santhanam Shanmughapriya Dhanendra Tomar Zhiwei Dong Katherine J. Slovik Neeharika Nemani Kalimuthusamy Natarajaseenivasan Edmund Carvalho Christy Lu Kaitlyn Corrigan Venkata Naga Srikanth Garikipati Jessica Ibetti Sudarsan Rajan Carlos Barrero Kurt Chuprun Raj Kishore Salim Merali Ying Tian Wenli Yang Muniswamy Madesh
author_facet	Santhanam Shanmughapriya Dhanendra Tomar Zhiwei Dong Katherine J. Slovik Neeharika Nemani Kalimuthusamy Natarajaseenivasan Edmund Carvalho Christy Lu Kaitlyn Corrigan Venkata Naga Srikanth Garikipati Jessica Ibetti Sudarsan Rajan Carlos Barrero Kurt Chuprun Raj Kishore Salim Merali Ying Tian Wenli Yang Muniswamy Madesh
author_sort	Santhanam Shanmughapriya
title	FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
title_short	FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
title_full	FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
title_fullStr	FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
title_full_unstemmed	FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
title_sort	foxd1-dependent micu1 expression regulates mitochondrial activity and cell differentiation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5af6e51c9e9c49309cc33ce6b1c415cc
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FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation

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