Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy

Marwa Abdelshafy, Ahmed Abdelshafy Ophthalmology Department, Benha Faculty of Medicine, Benha University, Benha, EgyptCorrespondence: Marwa AbdelshafyOphthalmology Department, Benha Faculty of Medicine, Benha University, 1 El Amira Fawzya Street, Benha, Qalubiya Governorate 13512, EgyptEmail drmarwa...

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Autores principales:	Abdelshafy M, Abdelshafy A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	visual acuity oct-angiography vessel density foveal avascular zone diabetic retinopathy. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/5afb73588cf146399bf4cdb784c3b38f
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spelling	oai:doaj.org-article:5afb73588cf146399bf4cdb784c3b38f2021-12-02T06:37:05ZCorrelations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy1177-5483https://doaj.org/article/5afb73588cf146399bf4cdb784c3b38f2020-04-01T00:00:00Zhttps://www.dovepress.com/correlations-between-optical-coherence-tomography-angiography-paramete-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Marwa Abdelshafy, Ahmed Abdelshafy Ophthalmology Department, Benha Faculty of Medicine, Benha University, Benha, EgyptCorrespondence: Marwa AbdelshafyOphthalmology Department, Benha Faculty of Medicine, Benha University, 1 El Amira Fawzya Street, Benha, Qalubiya Governorate 13512, EgyptEmail drmarwatabl2012@gmail.comAim: The aim of this study was to assess the correlation between different optical coherence tomography angiography (OCTA) parameters and the best corrected visual acuity (BCVA) in patients with diabetic retinopathy (DR).Patients and Methods: Sixty eyes of 60 participants were included in this prospective study: 40 diabetic patients [20 with non-proliferative diabetic retinopathy (NPDR group), 20 with proliferative diabetic retinopathy (PDR group)] and 20 age- and gender-matched normal healthy subjects (control group). After full ophthalmological examination and fundus fluorescein angiography, OCTA was performed for all participants. Quantitative OCTA parameters, such as the foveal avascular zone (FAZ) area, the superficial capillary plexus vessel density (%) (SCP-VD) and the deep capillary plexus vessel density (%) (DCP-VD) in, whole and parafoveal areas were measured. Correlations between BCVA and OCTA parameters were analyzed.Results: There were no statistically significant differences between groups regarding age, gender, refraction, macular thickness or intraocular pressure. The median (IQR) FAZ area was 0.42 (0.39– 0.46) mm2 in the NPDR group, 0.54 (0.45– 0.65) mm2 in the PDR group and 0.24 (0.21– 0.26) mm2 in the control group (P< 0.001). The FAZ area increased with increasing severity of DR. SCP-VD and DCP-VD showed significant differences between groups (P< 0.001). Vessel density (VD) was decreased in both DCP and SCP as DR progressed. There was a significant positive correlation between BCVA (LogMAR) and FAZ area. There were significant negative correlations between BCVA (LogMAR) and VD in both SCP and DCP. Stepwise multiple linear regression analysis demonstrated that SCP-VD in the whole area and DCP-VD in the parafoveal area were the best predictive factors for BCVA in the NPDR and PDR groups.Conclusion: With progression of DR, the VD decreased and the FAZ area increased, and both parameters were correlated with poor visual acuity. OCTA is a non-invasive tool which can be used to detect diabetic macular ischemia and help in the prediction of visual prognosis.Keywords: visual acuity, OCT angiography, vessel density, foveal avascular zone, diabetic retinopathyAbdelshafy MAbdelshafy ADove Medical Pressarticlevisual acuityoct-angiographyvessel densityfoveal avascular zonediabetic retinopathy.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1107-1115 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	visual acuity oct-angiography vessel density foveal avascular zone diabetic retinopathy. Ophthalmology RE1-994
spellingShingle	visual acuity oct-angiography vessel density foveal avascular zone diabetic retinopathy. Ophthalmology RE1-994 Abdelshafy M Abdelshafy A Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy
description	Marwa Abdelshafy, Ahmed Abdelshafy Ophthalmology Department, Benha Faculty of Medicine, Benha University, Benha, EgyptCorrespondence: Marwa AbdelshafyOphthalmology Department, Benha Faculty of Medicine, Benha University, 1 El Amira Fawzya Street, Benha, Qalubiya Governorate 13512, EgyptEmail drmarwatabl2012@gmail.comAim: The aim of this study was to assess the correlation between different optical coherence tomography angiography (OCTA) parameters and the best corrected visual acuity (BCVA) in patients with diabetic retinopathy (DR).Patients and Methods: Sixty eyes of 60 participants were included in this prospective study: 40 diabetic patients [20 with non-proliferative diabetic retinopathy (NPDR group), 20 with proliferative diabetic retinopathy (PDR group)] and 20 age- and gender-matched normal healthy subjects (control group). After full ophthalmological examination and fundus fluorescein angiography, OCTA was performed for all participants. Quantitative OCTA parameters, such as the foveal avascular zone (FAZ) area, the superficial capillary plexus vessel density (%) (SCP-VD) and the deep capillary plexus vessel density (%) (DCP-VD) in, whole and parafoveal areas were measured. Correlations between BCVA and OCTA parameters were analyzed.Results: There were no statistically significant differences between groups regarding age, gender, refraction, macular thickness or intraocular pressure. The median (IQR) FAZ area was 0.42 (0.39– 0.46) mm2 in the NPDR group, 0.54 (0.45– 0.65) mm2 in the PDR group and 0.24 (0.21– 0.26) mm2 in the control group (P< 0.001). The FAZ area increased with increasing severity of DR. SCP-VD and DCP-VD showed significant differences between groups (P< 0.001). Vessel density (VD) was decreased in both DCP and SCP as DR progressed. There was a significant positive correlation between BCVA (LogMAR) and FAZ area. There were significant negative correlations between BCVA (LogMAR) and VD in both SCP and DCP. Stepwise multiple linear regression analysis demonstrated that SCP-VD in the whole area and DCP-VD in the parafoveal area were the best predictive factors for BCVA in the NPDR and PDR groups.Conclusion: With progression of DR, the VD decreased and the FAZ area increased, and both parameters were correlated with poor visual acuity. OCTA is a non-invasive tool which can be used to detect diabetic macular ischemia and help in the prediction of visual prognosis.Keywords: visual acuity, OCT angiography, vessel density, foveal avascular zone, diabetic retinopathy
format	article
author	Abdelshafy M Abdelshafy A
author_facet	Abdelshafy M Abdelshafy A
author_sort	Abdelshafy M
title	Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy
title_short	Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy
title_full	Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy
title_fullStr	Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy
title_full_unstemmed	Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy
title_sort	correlations between optical coherence tomography angiography parameters and the visual acuity in patients with diabetic retinopathy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5afb73588cf146399bf4cdb784c3b38f
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Correlations Between Optical Coherence Tomography Angiography Parameters and the Visual Acuity in Patients with Diabetic Retinopathy

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