Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge

Dengue virus-specific antibody and CD8+ T cells that cross-react with Zika virus have been described. Here, the authors establish a functionally protective role for cross-reactive dengue virus-specific CD8+ T cells during challenge with Zika virus.

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Autores principales: Jinsheng Wen, Annie Elong Ngono, Jose Angel Regla-Nava, Kenneth Kim, Matthew J. Gorman, Michael S. Diamond, Sujan Shresta
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5afda4a06f2a4cd69385bda4898e1717
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Descripción
Sumario:Dengue virus-specific antibody and CD8+ T cells that cross-react with Zika virus have been described. Here, the authors establish a functionally protective role for cross-reactive dengue virus-specific CD8+ T cells during challenge with Zika virus.