Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge

Dengue virus-specific antibody and CD8+ T cells that cross-react with Zika virus have been described. Here, the authors establish a functionally protective role for cross-reactive dengue virus-specific CD8+ T cells during challenge with Zika virus.

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Autores principales: Jinsheng Wen, Annie Elong Ngono, Jose Angel Regla-Nava, Kenneth Kim, Matthew J. Gorman, Michael S. Diamond, Sujan Shresta
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5afda4a06f2a4cd69385bda4898e1717
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spelling oai:doaj.org-article:5afda4a06f2a4cd69385bda4898e17172021-12-02T15:38:40ZDengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge10.1038/s41467-017-01669-z2041-1723https://doaj.org/article/5afda4a06f2a4cd69385bda4898e17172017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01669-zhttps://doaj.org/toc/2041-1723Dengue virus-specific antibody and CD8+ T cells that cross-react with Zika virus have been described. Here, the authors establish a functionally protective role for cross-reactive dengue virus-specific CD8+ T cells during challenge with Zika virus.Jinsheng WenAnnie Elong NgonoJose Angel Regla-NavaKenneth KimMatthew J. GormanMichael S. DiamondSujan ShrestaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jinsheng Wen
Annie Elong Ngono
Jose Angel Regla-Nava
Kenneth Kim
Matthew J. Gorman
Michael S. Diamond
Sujan Shresta
Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge
description Dengue virus-specific antibody and CD8+ T cells that cross-react with Zika virus have been described. Here, the authors establish a functionally protective role for cross-reactive dengue virus-specific CD8+ T cells during challenge with Zika virus.
format article
author Jinsheng Wen
Annie Elong Ngono
Jose Angel Regla-Nava
Kenneth Kim
Matthew J. Gorman
Michael S. Diamond
Sujan Shresta
author_facet Jinsheng Wen
Annie Elong Ngono
Jose Angel Regla-Nava
Kenneth Kim
Matthew J. Gorman
Michael S. Diamond
Sujan Shresta
author_sort Jinsheng Wen
title Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge
title_short Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge
title_full Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge
title_fullStr Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge
title_full_unstemmed Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge
title_sort dengue virus-reactive cd8+ t cells mediate cross-protection against subsequent zika virus challenge
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/5afda4a06f2a4cd69385bda4898e1717
work_keys_str_mv AT jinshengwen denguevirusreactivecd8tcellsmediatecrossprotectionagainstsubsequentzikaviruschallenge
AT annieelongngono denguevirusreactivecd8tcellsmediatecrossprotectionagainstsubsequentzikaviruschallenge
AT joseangelreglanava denguevirusreactivecd8tcellsmediatecrossprotectionagainstsubsequentzikaviruschallenge
AT kennethkim denguevirusreactivecd8tcellsmediatecrossprotectionagainstsubsequentzikaviruschallenge
AT matthewjgorman denguevirusreactivecd8tcellsmediatecrossprotectionagainstsubsequentzikaviruschallenge
AT michaelsdiamond denguevirusreactivecd8tcellsmediatecrossprotectionagainstsubsequentzikaviruschallenge
AT sujanshresta denguevirusreactivecd8tcellsmediatecrossprotectionagainstsubsequentzikaviruschallenge
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