Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease
The use of PET for detection of Aβ in the brain in AD has limitations; studies also indicate that retinal changes, including Aβ deposition, occur in AD. Here the authors demonstrate the potential to use in vivo retinal hyperspectral imaging as a surrogate for brain accumulation of Aβ.
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Nature Portfolio
2019
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oai:doaj.org-article:5b0130579595439f8f0a226f8d6265b22021-12-02T16:57:31ZNon-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease10.1038/s41467-019-12242-12041-1723https://doaj.org/article/5b0130579595439f8f0a226f8d6265b22019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12242-1https://doaj.org/toc/2041-1723The use of PET for detection of Aβ in the brain in AD has limitations; studies also indicate that retinal changes, including Aβ deposition, occur in AD. Here the authors demonstrate the potential to use in vivo retinal hyperspectral imaging as a surrogate for brain accumulation of Aβ.Xavier HadouxFlora HuiJeremiah K. H. LimColin L. MastersAlice PébaySophie ChevalierJason HaSamantha LoiChristopher J. FowlerChristopher RoweVictor L. VillemagneEdward N. TaylorChristopher FlukeJean-Paul SoucyFrédéric LesageJean-Philippe SylvestrePedro Rosa-NetoSulantha MathotaarachchiSerge GauthierZiad S. NasreddineJean Daniel ArbourMarc-André RhéaumeSylvain BeaulieuMohamed DiraniChristine T. O. NguyenBang V. BuiRobert WilliamsonJonathan G. CrowstonPeter van WijngaardenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Xavier Hadoux Flora Hui Jeremiah K. H. Lim Colin L. Masters Alice Pébay Sophie Chevalier Jason Ha Samantha Loi Christopher J. Fowler Christopher Rowe Victor L. Villemagne Edward N. Taylor Christopher Fluke Jean-Paul Soucy Frédéric Lesage Jean-Philippe Sylvestre Pedro Rosa-Neto Sulantha Mathotaarachchi Serge Gauthier Ziad S. Nasreddine Jean Daniel Arbour Marc-André Rhéaume Sylvain Beaulieu Mohamed Dirani Christine T. O. Nguyen Bang V. Bui Robert Williamson Jonathan G. Crowston Peter van Wijngaarden Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease |
| description |
The use of PET for detection of Aβ in the brain in AD has limitations; studies also indicate that retinal changes, including Aβ deposition, occur in AD. Here the authors demonstrate the potential to use in vivo retinal hyperspectral imaging as a surrogate for brain accumulation of Aβ. |
| format |
article |
| author |
Xavier Hadoux Flora Hui Jeremiah K. H. Lim Colin L. Masters Alice Pébay Sophie Chevalier Jason Ha Samantha Loi Christopher J. Fowler Christopher Rowe Victor L. Villemagne Edward N. Taylor Christopher Fluke Jean-Paul Soucy Frédéric Lesage Jean-Philippe Sylvestre Pedro Rosa-Neto Sulantha Mathotaarachchi Serge Gauthier Ziad S. Nasreddine Jean Daniel Arbour Marc-André Rhéaume Sylvain Beaulieu Mohamed Dirani Christine T. O. Nguyen Bang V. Bui Robert Williamson Jonathan G. Crowston Peter van Wijngaarden |
| author_facet |
Xavier Hadoux Flora Hui Jeremiah K. H. Lim Colin L. Masters Alice Pébay Sophie Chevalier Jason Ha Samantha Loi Christopher J. Fowler Christopher Rowe Victor L. Villemagne Edward N. Taylor Christopher Fluke Jean-Paul Soucy Frédéric Lesage Jean-Philippe Sylvestre Pedro Rosa-Neto Sulantha Mathotaarachchi Serge Gauthier Ziad S. Nasreddine Jean Daniel Arbour Marc-André Rhéaume Sylvain Beaulieu Mohamed Dirani Christine T. O. Nguyen Bang V. Bui Robert Williamson Jonathan G. Crowston Peter van Wijngaarden |
| author_sort |
Xavier Hadoux |
| title |
Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease |
| title_short |
Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease |
| title_full |
Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease |
| title_fullStr |
Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease |
| title_full_unstemmed |
Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease |
| title_sort |
non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in alzheimer’s disease |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/5b0130579595439f8f0a226f8d6265b2 |
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