Obesity is a risk factor for central precocious puberty: a case-control study

Abstract Background Obesity is an important underlying cause of central precocious puberty (CPP), but previous large studies are flawed by using just age and breast examination to diagnose CPP. We aimed to determine whether overweight and obesity in childhood increases hormonally diagnosed CPP. Meth...

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Autores principales:	Gaiyan Liu, Jinxin Guo, Xuejing Zhang, Yu Lu, Junjie Miao, Hongmei Xue
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Central precocious puberty Overweight Obesity Case-control study Puberty onset Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/5b09f380b78249138435124b595b3437
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spelling	oai:doaj.org-article:5b09f380b78249138435124b595b34372021-11-21T12:33:25ZObesity is a risk factor for central precocious puberty: a case-control study10.1186/s12887-021-02936-11471-2431https://doaj.org/article/5b09f380b78249138435124b595b34372021-11-01T00:00:00Zhttps://doi.org/10.1186/s12887-021-02936-1https://doaj.org/toc/1471-2431Abstract Background Obesity is an important underlying cause of central precocious puberty (CPP), but previous large studies are flawed by using just age and breast examination to diagnose CPP. We aimed to determine whether overweight and obesity in childhood increases hormonally diagnosed CPP. Methods Our retrospective, case-control study recruited 846 children diagnosed as having CPP and randomly sampled 1650 healthy control subjects in Xingtai Third Hospital in China between November 2018 and March 2021. Information was obtained from an electronic medical record and questionnaire investigated in the outpatient visit. Observations were made before the a priori hypothesis. Unconditional logistic regression for analysis was used to determine whether overweight and obesity status and duration of overweight/obesity were associated with CPP. Results Overweight and obesity were significantly associated with increased odds of CPP among girls, even after adjusting for birth weight, exclusive breastfeeding for 6 month, household income, maternal overweight, paternal overweight, and maternal menarche age (overweight: the adjusted odds ratio (aOR) (95%CI): 1.92 (1.16, 3.24), p = 0.02; obesity: aOR (95%CI): 1.78 (1.13, 3.48), p = 0.03). Furthermore, the effects of overweight and obesity were significant when ongoing for 1 to 2 years, 2 to 3 years, and greater than 3 years, but not at less than 1 year. For boys, association between obesity and increased odds of CPP was observed (aOR (95%CI): 1.68 (1.09, 3.75), p = 0.03). The effects of overweight and/or obesity were only significant when ongoing for greater than 2 years. Conclusions Prolonged overweight and obesity in early childhood may be risk factors for CPP, especially in girls. Weight loss might be an important approach for the prevention of precocious puberty in children.Gaiyan LiuJinxin GuoXuejing ZhangYu LuJunjie MiaoHongmei XueBMCarticleCentral precocious pubertyOverweightObesityCase-control studyPuberty onsetPediatricsRJ1-570ENBMC Pediatrics, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Central precocious puberty Overweight Obesity Case-control study Puberty onset Pediatrics RJ1-570
spellingShingle	Central precocious puberty Overweight Obesity Case-control study Puberty onset Pediatrics RJ1-570 Gaiyan Liu Jinxin Guo Xuejing Zhang Yu Lu Junjie Miao Hongmei Xue Obesity is a risk factor for central precocious puberty: a case-control study
description	Abstract Background Obesity is an important underlying cause of central precocious puberty (CPP), but previous large studies are flawed by using just age and breast examination to diagnose CPP. We aimed to determine whether overweight and obesity in childhood increases hormonally diagnosed CPP. Methods Our retrospective, case-control study recruited 846 children diagnosed as having CPP and randomly sampled 1650 healthy control subjects in Xingtai Third Hospital in China between November 2018 and March 2021. Information was obtained from an electronic medical record and questionnaire investigated in the outpatient visit. Observations were made before the a priori hypothesis. Unconditional logistic regression for analysis was used to determine whether overweight and obesity status and duration of overweight/obesity were associated with CPP. Results Overweight and obesity were significantly associated with increased odds of CPP among girls, even after adjusting for birth weight, exclusive breastfeeding for 6 month, household income, maternal overweight, paternal overweight, and maternal menarche age (overweight: the adjusted odds ratio (aOR) (95%CI): 1.92 (1.16, 3.24), p = 0.02; obesity: aOR (95%CI): 1.78 (1.13, 3.48), p = 0.03). Furthermore, the effects of overweight and obesity were significant when ongoing for 1 to 2 years, 2 to 3 years, and greater than 3 years, but not at less than 1 year. For boys, association between obesity and increased odds of CPP was observed (aOR (95%CI): 1.68 (1.09, 3.75), p = 0.03). The effects of overweight and/or obesity were only significant when ongoing for greater than 2 years. Conclusions Prolonged overweight and obesity in early childhood may be risk factors for CPP, especially in girls. Weight loss might be an important approach for the prevention of precocious puberty in children.
format	article
author	Gaiyan Liu Jinxin Guo Xuejing Zhang Yu Lu Junjie Miao Hongmei Xue
author_facet	Gaiyan Liu Jinxin Guo Xuejing Zhang Yu Lu Junjie Miao Hongmei Xue
author_sort	Gaiyan Liu
title	Obesity is a risk factor for central precocious puberty: a case-control study
title_short	Obesity is a risk factor for central precocious puberty: a case-control study
title_full	Obesity is a risk factor for central precocious puberty: a case-control study
title_fullStr	Obesity is a risk factor for central precocious puberty: a case-control study
title_full_unstemmed	Obesity is a risk factor for central precocious puberty: a case-control study
title_sort	obesity is a risk factor for central precocious puberty: a case-control study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5b09f380b78249138435124b595b3437
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_version_	1718418945082392576

Obesity is a risk factor for central precocious puberty: a case-control study

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