DNA methylation in schizophrenia in different patient-derived cell types

Epigenetics: A genome-wide picture in patient-derived cells Schizophrenia-associated differences in the DNA methylation status of patient-derived cells suggest it could affect early brain development. Mechanisms that control gene expression without altering the genetic code, such as DNA methylation,...

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Autores principales:	Alejandra M. Vitale, Nicholas A. Matigian, Alexandre S. Cristino, Katia Nones, Sugandha Ravishankar, Bernadette Bellette, Yongjun Fan, Stephen A. Wood, Ernst Wolvetang, Alan Mackay-Sim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/5b0cc3f9768c4ac98732fd625650c1cb
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spelling	oai:doaj.org-article:5b0cc3f9768c4ac98732fd625650c1cb2021-12-02T15:18:48ZDNA methylation in schizophrenia in different patient-derived cell types10.1038/s41537-016-0006-02334-265Xhttps://doaj.org/article/5b0cc3f9768c4ac98732fd625650c1cb2017-01-01T00:00:00Zhttps://doi.org/10.1038/s41537-016-0006-0https://doaj.org/toc/2334-265XEpigenetics: A genome-wide picture in patient-derived cells Schizophrenia-associated differences in the DNA methylation status of patient-derived cells suggest it could affect early brain development. Mechanisms that control gene expression without altering the genetic code, such as DNA methylation, could explain how environmental risk factors contribute to schizophrenia in genetically susceptible individuals. Alan Mackay-Sim and colleagues from Griffith University, Australia, carried out genome-wide comparisons of DNA methylation in induced pluripotent stem (iPS) cells, olfactory neurosphere-derived cells and fibroblasts from patients and controls. Differences in the DNA methylation pattern between patient and control iPS cells, which could reflect what happens in the embryo, suggest a disease-associated effect very early on in development. Only five genes were differentially methylated in all three patient-derived cell types compared to controls. None of these genes has previously been associated with schizophrenia and may represent new targets for future research.Alejandra M. VitaleNicholas A. MatigianAlexandre S. CristinoKatia NonesSugandha RavishankarBernadette BelletteYongjun FanStephen A. WoodErnst WolvetangAlan Mackay-SimNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 3, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Alejandra M. Vitale Nicholas A. Matigian Alexandre S. Cristino Katia Nones Sugandha Ravishankar Bernadette Bellette Yongjun Fan Stephen A. Wood Ernst Wolvetang Alan Mackay-Sim DNA methylation in schizophrenia in different patient-derived cell types
description	Epigenetics: A genome-wide picture in patient-derived cells Schizophrenia-associated differences in the DNA methylation status of patient-derived cells suggest it could affect early brain development. Mechanisms that control gene expression without altering the genetic code, such as DNA methylation, could explain how environmental risk factors contribute to schizophrenia in genetically susceptible individuals. Alan Mackay-Sim and colleagues from Griffith University, Australia, carried out genome-wide comparisons of DNA methylation in induced pluripotent stem (iPS) cells, olfactory neurosphere-derived cells and fibroblasts from patients and controls. Differences in the DNA methylation pattern between patient and control iPS cells, which could reflect what happens in the embryo, suggest a disease-associated effect very early on in development. Only five genes were differentially methylated in all three patient-derived cell types compared to controls. None of these genes has previously been associated with schizophrenia and may represent new targets for future research.
format	article
author	Alejandra M. Vitale Nicholas A. Matigian Alexandre S. Cristino Katia Nones Sugandha Ravishankar Bernadette Bellette Yongjun Fan Stephen A. Wood Ernst Wolvetang Alan Mackay-Sim
author_facet	Alejandra M. Vitale Nicholas A. Matigian Alexandre S. Cristino Katia Nones Sugandha Ravishankar Bernadette Bellette Yongjun Fan Stephen A. Wood Ernst Wolvetang Alan Mackay-Sim
author_sort	Alejandra M. Vitale
title	DNA methylation in schizophrenia in different patient-derived cell types
title_short	DNA methylation in schizophrenia in different patient-derived cell types
title_full	DNA methylation in schizophrenia in different patient-derived cell types
title_fullStr	DNA methylation in schizophrenia in different patient-derived cell types
title_full_unstemmed	DNA methylation in schizophrenia in different patient-derived cell types
title_sort	dna methylation in schizophrenia in different patient-derived cell types
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5b0cc3f9768c4ac98732fd625650c1cb
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DNA methylation in schizophrenia in different patient-derived cell types

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