Exploration of sex differences in Rhes effects in dopamine mediated behaviors

Gabriel C Quintero1,2, Daniela Spano31INDICASAT AIP, Centro de Neurociencias, Panam&aacute;, 2Department of Psychology, University of New Orleans, N Orleans, Louisiana, USA; 3CEINGE Biotechnologie Avanzate, Naples, ItalyAbstract: Studies have shown that Ras homolog enriched in striatum (Rhes...

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Autores principales:	Quintero GC, Spano D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5b0e6e14cde34f0a90d8cac0b162eefb
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spelling	oai:doaj.org-article:5b0e6e14cde34f0a90d8cac0b162eefb2021-12-02T05:12:20ZExploration of sex differences in Rhes effects in dopamine mediated behaviors1176-63281178-2021https://doaj.org/article/5b0e6e14cde34f0a90d8cac0b162eefb2011-11-01T00:00:00Zhttp://www.dovepress.com/exploration-of-sex-differences-in-rhes-effects-in-dopamine-mediated-be-a8683https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Gabriel C Quintero1,2, Daniela Spano31INDICASAT AIP, Centro de Neurociencias, Panam&aacute;, 2Department of Psychology, University of New Orleans, N Orleans, Louisiana, USA; 3CEINGE Biotechnologie Avanzate, Naples, ItalyAbstract: Studies have shown that Ras homolog enriched in striatum (Rhes) proteins are highly expressed in areas of the central nervous system that have high dopaminergic innervation. In this study, we used Rhes mutant mice (Wild type, Rhes KO, Rhes Heterozygous) of both sexes to explore differences in the effects of Rhes protein levels in basal levels of activity, anxiety, and stereotypy, in relation to sex. Adult male and female mice were evaluated in an open field test for measuring basal levels of activity and anxiety for 5 consecutive days, and they were tested in the apomorphine-induced stereotypy paradigm. Rhes protein levels affected basal levels of activity but it was not found to be related to sex differences. Moreover, a decrease in Rhes protein levels was linked to a nonsignificant anxiolytic effect, mainly in female mice. Finally, a decrease in Rhes protein levels does not affect dopamine D1 and D2 receptor (D1/D2) synergism in female or male mice. Together, these results suggest that Rhes protein levels affect locomotion activity, and have an influence in anxiety depending on sex; Rhes protein levels do not affect D1/D2 synergism in both sexes.Keywords: behavior, dopamine receptor, Rhes protein, mutant mice, sexesQuintero GCSpano DDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2011, Iss Issue 1, Pp 697-706 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Quintero GC Spano D Exploration of sex differences in Rhes effects in dopamine mediated behaviors
description	Gabriel C Quintero1,2, Daniela Spano31INDICASAT AIP, Centro de Neurociencias, Panam&aacute;, 2Department of Psychology, University of New Orleans, N Orleans, Louisiana, USA; 3CEINGE Biotechnologie Avanzate, Naples, ItalyAbstract: Studies have shown that Ras homolog enriched in striatum (Rhes) proteins are highly expressed in areas of the central nervous system that have high dopaminergic innervation. In this study, we used Rhes mutant mice (Wild type, Rhes KO, Rhes Heterozygous) of both sexes to explore differences in the effects of Rhes protein levels in basal levels of activity, anxiety, and stereotypy, in relation to sex. Adult male and female mice were evaluated in an open field test for measuring basal levels of activity and anxiety for 5 consecutive days, and they were tested in the apomorphine-induced stereotypy paradigm. Rhes protein levels affected basal levels of activity but it was not found to be related to sex differences. Moreover, a decrease in Rhes protein levels was linked to a nonsignificant anxiolytic effect, mainly in female mice. Finally, a decrease in Rhes protein levels does not affect dopamine D1 and D2 receptor (D1/D2) synergism in female or male mice. Together, these results suggest that Rhes protein levels affect locomotion activity, and have an influence in anxiety depending on sex; Rhes protein levels do not affect D1/D2 synergism in both sexes.Keywords: behavior, dopamine receptor, Rhes protein, mutant mice, sexes
format	article
author	Quintero GC Spano D
author_facet	Quintero GC Spano D
author_sort	Quintero GC
title	Exploration of sex differences in Rhes effects in dopamine mediated behaviors
title_short	Exploration of sex differences in Rhes effects in dopamine mediated behaviors
title_full	Exploration of sex differences in Rhes effects in dopamine mediated behaviors
title_fullStr	Exploration of sex differences in Rhes effects in dopamine mediated behaviors
title_full_unstemmed	Exploration of sex differences in Rhes effects in dopamine mediated behaviors
title_sort	exploration of sex differences in rhes effects in dopamine mediated behaviors
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/5b0e6e14cde34f0a90d8cac0b162eefb
work_keys_str_mv	AT quinterogc explorationofsexdifferencesinrheseffectsindopaminemediatedbehaviors AT spanod explorationofsexdifferencesinrheseffectsindopaminemediatedbehaviors
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Exploration of sex differences in Rhes effects in dopamine mediated behaviors

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