Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species

Antivenoms, obtained by venom immunization, have narrow species coverage due to low immunogenicity of venom neurotoxins. Here the authors immunize horses with a designed recombinant consensus neurotoxin, and the resulting antisera protect mice from envenomation by a broad spectrum of elapid snakes.

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Autores principales:	Guillermo de la Rosa, Felipe Olvera, Irving G. Archundia, Bruno Lomonte, Alejandro Alagón, Gerardo Corzo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b0ed9b560b54fefb244e4fecf25d012
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spelling	oai:doaj.org-article:5b0ed9b560b54fefb244e4fecf25d0122021-12-02T14:39:37ZHorse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species10.1038/s41467-019-11639-22041-1723https://doaj.org/article/5b0ed9b560b54fefb244e4fecf25d0122019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11639-2https://doaj.org/toc/2041-1723Antivenoms, obtained by venom immunization, have narrow species coverage due to low immunogenicity of venom neurotoxins. Here the authors immunize horses with a designed recombinant consensus neurotoxin, and the resulting antisera protect mice from envenomation by a broad spectrum of elapid snakes.Guillermo de la RosaFelipe OlveraIrving G. ArchundiaBruno LomonteAlejandro AlagónGerardo CorzoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guillermo de la Rosa Felipe Olvera Irving G. Archundia Bruno Lomonte Alejandro Alagón Gerardo Corzo Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species
description	Antivenoms, obtained by venom immunization, have narrow species coverage due to low immunogenicity of venom neurotoxins. Here the authors immunize horses with a designed recombinant consensus neurotoxin, and the resulting antisera protect mice from envenomation by a broad spectrum of elapid snakes.
format	article
author	Guillermo de la Rosa Felipe Olvera Irving G. Archundia Bruno Lomonte Alejandro Alagón Gerardo Corzo
author_facet	Guillermo de la Rosa Felipe Olvera Irving G. Archundia Bruno Lomonte Alejandro Alagón Gerardo Corzo
author_sort	Guillermo de la Rosa
title	Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species
title_short	Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species
title_full	Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species
title_fullStr	Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species
title_full_unstemmed	Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species
title_sort	horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5b0ed9b560b54fefb244e4fecf25d012
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Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species

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