A universal trend among proteomes indicates an oily last common ancestor.

Despite progresses in ancestral protein sequence reconstruction, much needs to be unraveled about the nature of the putative last common ancestral proteome that served as the prototype of all extant lifeforms. Here, we present data that indicate a steady decline (oil escape) in proteome hydrophobici...

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Autores principales:	Ranjan V Mannige, Charles L Brooks, Eugene I Shakhnovich
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5b0f267f43f9426f88fb49d68a6deaf4
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spelling	oai:doaj.org-article:5b0f267f43f9426f88fb49d68a6deaf42021-11-18T05:52:34ZA universal trend among proteomes indicates an oily last common ancestor.1553-734X1553-735810.1371/journal.pcbi.1002839https://doaj.org/article/5b0f267f43f9426f88fb49d68a6deaf42012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300421/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Despite progresses in ancestral protein sequence reconstruction, much needs to be unraveled about the nature of the putative last common ancestral proteome that served as the prototype of all extant lifeforms. Here, we present data that indicate a steady decline (oil escape) in proteome hydrophobicity over species evolvedness (node number) evident in 272 diverse proteomes, which indicates a highly hydrophobic (oily) last common ancestor (LCA). This trend, obtained from simple considerations (free from sequence reconstruction methods), was corroborated by regression studies within homologous and orthologous protein clusters as well as phylogenetic estimates of the ancestral oil content. While indicating an inherent irreversibility in molecular evolution, oil escape also serves as a rare and universal reaction-coordinate for evolution (reinforcing Darwin's principle of Common Descent), and may prove important in matters such as (i) explaining the emergence of intrinsically disordered proteins, (ii) developing composition- and speciation-based "global" molecular clocks, and (iii) improving the statistical methods for ancestral sequence reconstruction.Ranjan V MannigeCharles L BrooksEugene I ShakhnovichPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 12, p e1002839 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ranjan V Mannige Charles L Brooks Eugene I Shakhnovich A universal trend among proteomes indicates an oily last common ancestor.
description	Despite progresses in ancestral protein sequence reconstruction, much needs to be unraveled about the nature of the putative last common ancestral proteome that served as the prototype of all extant lifeforms. Here, we present data that indicate a steady decline (oil escape) in proteome hydrophobicity over species evolvedness (node number) evident in 272 diverse proteomes, which indicates a highly hydrophobic (oily) last common ancestor (LCA). This trend, obtained from simple considerations (free from sequence reconstruction methods), was corroborated by regression studies within homologous and orthologous protein clusters as well as phylogenetic estimates of the ancestral oil content. While indicating an inherent irreversibility in molecular evolution, oil escape also serves as a rare and universal reaction-coordinate for evolution (reinforcing Darwin's principle of Common Descent), and may prove important in matters such as (i) explaining the emergence of intrinsically disordered proteins, (ii) developing composition- and speciation-based "global" molecular clocks, and (iii) improving the statistical methods for ancestral sequence reconstruction.
format	article
author	Ranjan V Mannige Charles L Brooks Eugene I Shakhnovich
author_facet	Ranjan V Mannige Charles L Brooks Eugene I Shakhnovich
author_sort	Ranjan V Mannige
title	A universal trend among proteomes indicates an oily last common ancestor.
title_short	A universal trend among proteomes indicates an oily last common ancestor.
title_full	A universal trend among proteomes indicates an oily last common ancestor.
title_fullStr	A universal trend among proteomes indicates an oily last common ancestor.
title_full_unstemmed	A universal trend among proteomes indicates an oily last common ancestor.
title_sort	universal trend among proteomes indicates an oily last common ancestor.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5b0f267f43f9426f88fb49d68a6deaf4
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A universal trend among proteomes indicates an oily last common ancestor.

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