Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery

Nina Wijiani, Dewi Isadiartuti, M Agus Syamsur Rijal, Helmy Yusuf Department of Pharmaceutics, Universitas Airlangga, Surabaya, IndonesiaCorrespondence: Helmy YusufDepartment of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, IndonesiaTel +62 31 5933150Fax +62 31 5935249Em...

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Autores principales:	Wijiani N, Isadiartuti D, Rijal MAS, Yusuf H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	micelles amorphous crystalline solid dispersion dissolution powder Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5b0f3b33ceb7416191879ce644b422d6
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spelling	oai:doaj.org-article:5b0f3b33ceb7416191879ce644b422d62021-12-02T08:53:28ZCharacterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery1178-2013https://doaj.org/article/5b0f3b33ceb7416191879ce644b422d62020-03-01T00:00:00Zhttps://www.dovepress.com/characterization-and-dissolution-study-of-micellar-curcumin-spray-drie-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Nina Wijiani, Dewi Isadiartuti, M Agus Syamsur Rijal, Helmy Yusuf Department of Pharmaceutics, Universitas Airlangga, Surabaya, IndonesiaCorrespondence: Helmy YusufDepartment of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, IndonesiaTel +62 31 5933150Fax +62 31 5935249Email helmy-yusuf@ff.unair.ac.idIntroduction: Curcumin faces a major challenge in clinical use due to its poor aqueous solubility, which affects its bioavailability over oral use. The present study was carried out to overcome this problem.Methods: An amorphous micellar curcumin-spray dried powder (MC-SDP) with self-assembled casein was prepared by the addition of sucrose as a protectant. The dry powder of curcumin-loaded micelles was obtained by a spray-drying technique in the presence of sucrose as a protectant. The MC-SDP in the form of dry powder was further developed into tablets to investigate the dissolution profile. The physical properties of preformed powder were characterized by differential thermal analysis (DTA), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Quantitative analysis in the form of solutions was analyzed by high-performance liquid chromatography (HPLC).Results: The physical properties demonstrated that MC-SDP varies from dented to smoother surfaces as a function of sucrose. Furthermore, melting transitions of curcumin in the form of MC-SDP were broadened in all sample mixtures, as observed in the DTA thermogram. The XRD spectra showed that the sharp and very intense peaks of single curcumin crystalline structure no longer existed in all MC-SDP forms, indicating that the mixtures were amorphous. Moreover, a further dissolution study of MC-SDP showed a significant increase of drug dissolved with the presence of sucrose, where > 80% of curcumin from MC-SDP was dissolved within 30 min.Conclusion: The study demonstrated the manufacture of micellar spray-dried powder that would contribute to the development of oral delivery of curcumin.Keywords: micellar, amorphous, crystalline, solid dispersion, dissolution, powderWijiani NIsadiartuti DRijal MASYusuf HDove Medical Pressarticlemicellesamorphouscrystallinesolid dispersiondissolutionpowderMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 1787-1796 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	micelles amorphous crystalline solid dispersion dissolution powder Medicine (General) R5-920
spellingShingle	micelles amorphous crystalline solid dispersion dissolution powder Medicine (General) R5-920 Wijiani N Isadiartuti D Rijal MAS Yusuf H Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery
description	Nina Wijiani, Dewi Isadiartuti, M Agus Syamsur Rijal, Helmy Yusuf Department of Pharmaceutics, Universitas Airlangga, Surabaya, IndonesiaCorrespondence: Helmy YusufDepartment of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, IndonesiaTel +62 31 5933150Fax +62 31 5935249Email helmy-yusuf@ff.unair.ac.idIntroduction: Curcumin faces a major challenge in clinical use due to its poor aqueous solubility, which affects its bioavailability over oral use. The present study was carried out to overcome this problem.Methods: An amorphous micellar curcumin-spray dried powder (MC-SDP) with self-assembled casein was prepared by the addition of sucrose as a protectant. The dry powder of curcumin-loaded micelles was obtained by a spray-drying technique in the presence of sucrose as a protectant. The MC-SDP in the form of dry powder was further developed into tablets to investigate the dissolution profile. The physical properties of preformed powder were characterized by differential thermal analysis (DTA), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Quantitative analysis in the form of solutions was analyzed by high-performance liquid chromatography (HPLC).Results: The physical properties demonstrated that MC-SDP varies from dented to smoother surfaces as a function of sucrose. Furthermore, melting transitions of curcumin in the form of MC-SDP were broadened in all sample mixtures, as observed in the DTA thermogram. The XRD spectra showed that the sharp and very intense peaks of single curcumin crystalline structure no longer existed in all MC-SDP forms, indicating that the mixtures were amorphous. Moreover, a further dissolution study of MC-SDP showed a significant increase of drug dissolved with the presence of sucrose, where > 80% of curcumin from MC-SDP was dissolved within 30 min.Conclusion: The study demonstrated the manufacture of micellar spray-dried powder that would contribute to the development of oral delivery of curcumin.Keywords: micellar, amorphous, crystalline, solid dispersion, dissolution, powder
format	article
author	Wijiani N Isadiartuti D Rijal MAS Yusuf H
author_facet	Wijiani N Isadiartuti D Rijal MAS Yusuf H
author_sort	Wijiani N
title	Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery
title_short	Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery
title_full	Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery
title_fullStr	Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery
title_full_unstemmed	Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery
title_sort	characterization and dissolution study of micellar curcumin-spray dried powder for oral delivery
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5b0f3b33ceb7416191879ce644b422d6
work_keys_str_mv	AT wijianin characterizationanddissolutionstudyofmicellarcurcuminspraydriedpowderfororaldelivery AT isadiartutid characterizationanddissolutionstudyofmicellarcurcuminspraydriedpowderfororaldelivery AT rijalmas characterizationanddissolutionstudyofmicellarcurcuminspraydriedpowderfororaldelivery AT yusufh characterizationanddissolutionstudyofmicellarcurcuminspraydriedpowderfororaldelivery
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Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery

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