Clinical evaluation of the effect of hydroalcoholic extract of Hypericum perforatum on the healing of oral lesions of Foot and mouth disease in cattle

Formation of excessive blisters and sores on the mouth of affected cattle with Foot-and-Mouth disease and the insufficiency of existing therapeutic methods, leads to extensive damages to the affected herds. The extract of Hypericum perforatum and its active ingredient, Hypericin, have inhibitory eff...

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Autores principales:	mohammad tolouei, amir daneshvar, hosein tayefi-nasrabadi, omid madadgar
Formato:	article
Lenguaje:	FA
Publicado:	Islamic Azad University, Tabriz Branch 2021
Materias:	cattle foot and mouth disease hypericum perforatum mouth lesions treatment Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/5b11b2e077e14772a4639aabbe55db4e
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spelling	oai:doaj.org-article:5b11b2e077e14772a4639aabbe55db4e2021-11-09T05:50:10ZClinical evaluation of the effect of hydroalcoholic extract of Hypericum perforatum on the healing of oral lesions of Foot and mouth disease in cattle2322-47462476-698410.30495/jvcp.2021.1923074.1299https://doaj.org/article/5b11b2e077e14772a4639aabbe55db4e2021-04-01T00:00:00Zhttp://jvcp.iaut.ac.ir/article_682486_608c259f5487152b5084c03778b5dc9b.pdfhttps://doaj.org/toc/2322-4746https://doaj.org/toc/2476-6984Formation of excessive blisters and sores on the mouth of affected cattle with Foot-and-Mouth disease and the insufficiency of existing therapeutic methods, leads to extensive damages to the affected herds. The extract of Hypericum perforatum and its active ingredient, Hypericin, have inhibitory effects on the adsorption ability of Foot-and-Mouth virus to host cells in vitro. The medicinal plant also has an effective role in healing various kinds of wounds. The aim of this study was to evaluate the efficacy of H. perforatum extract on the healing of FMD oral lesions in affected cattle. In this study, 72 affected cattle (36 heads in 3 treatment groups of 12 and 36 heads in 3 control groups of 12) from 3 conflict centers in West-Azarbaijan province were selected. Determination of serotype by complement fixation method indicated that the studied animals were infected with serotype O of FMD. Dry aerial parts of H. perforatum were extracted with maceration method and 0.25, 0.5 and 5% concentrations of hydroalcoholic extract were prepared. In control groups, normal saline solution and in treatment groups, the extract with the mentioned concentrations was used as an oral spray (twice a day for 4 days). Cattle treated with 5% extract had a significant improvement in oral lesions and lesion repair during the treatment period was significantly different from the control groups (p<0.05). The results showed that spraying 5% concentration of H. perforatum extract had significant healing effects on oral lesions caused by FMD.mohammad toloueiamir daneshvarhosein tayefi-nasrabadiomid madadgarIslamic Azad University, Tabriz Brancharticlecattlefoot and mouth diseasehypericum perforatummouth lesionstreatmentVeterinary medicineSF600-1100FAĀsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, Vol 15, Iss 1 (57) بهار, Pp 61-73 (2021)
institution	DOAJ
collection	DOAJ
language	FA
topic	cattle foot and mouth disease hypericum perforatum mouth lesions treatment Veterinary medicine SF600-1100
spellingShingle	cattle foot and mouth disease hypericum perforatum mouth lesions treatment Veterinary medicine SF600-1100 mohammad tolouei amir daneshvar hosein tayefi-nasrabadi omid madadgar Clinical evaluation of the effect of hydroalcoholic extract of Hypericum perforatum on the healing of oral lesions of Foot and mouth disease in cattle
description	Formation of excessive blisters and sores on the mouth of affected cattle with Foot-and-Mouth disease and the insufficiency of existing therapeutic methods, leads to extensive damages to the affected herds. The extract of Hypericum perforatum and its active ingredient, Hypericin, have inhibitory effects on the adsorption ability of Foot-and-Mouth virus to host cells in vitro. The medicinal plant also has an effective role in healing various kinds of wounds. The aim of this study was to evaluate the efficacy of H. perforatum extract on the healing of FMD oral lesions in affected cattle. In this study, 72 affected cattle (36 heads in 3 treatment groups of 12 and 36 heads in 3 control groups of 12) from 3 conflict centers in West-Azarbaijan province were selected. Determination of serotype by complement fixation method indicated that the studied animals were infected with serotype O of FMD. Dry aerial parts of H. perforatum were extracted with maceration method and 0.25, 0.5 and 5% concentrations of hydroalcoholic extract were prepared. In control groups, normal saline solution and in treatment groups, the extract with the mentioned concentrations was used as an oral spray (twice a day for 4 days). Cattle treated with 5% extract had a significant improvement in oral lesions and lesion repair during the treatment period was significantly different from the control groups (p<0.05). The results showed that spraying 5% concentration of H. perforatum extract had significant healing effects on oral lesions caused by FMD.
format	article
author	mohammad tolouei amir daneshvar hosein tayefi-nasrabadi omid madadgar
author_facet	mohammad tolouei amir daneshvar hosein tayefi-nasrabadi omid madadgar
author_sort	mohammad tolouei
title	Clinical evaluation of the effect of hydroalcoholic extract of Hypericum perforatum on the healing of oral lesions of Foot and mouth disease in cattle
title_short	Clinical evaluation of the effect of hydroalcoholic extract of Hypericum perforatum on the healing of oral lesions of Foot and mouth disease in cattle
title_full	Clinical evaluation of the effect of hydroalcoholic extract of Hypericum perforatum on the healing of oral lesions of Foot and mouth disease in cattle
title_fullStr	Clinical evaluation of the effect of hydroalcoholic extract of Hypericum perforatum on the healing of oral lesions of Foot and mouth disease in cattle
title_full_unstemmed	Clinical evaluation of the effect of hydroalcoholic extract of Hypericum perforatum on the healing of oral lesions of Foot and mouth disease in cattle
title_sort	clinical evaluation of the effect of hydroalcoholic extract of hypericum perforatum on the healing of oral lesions of foot and mouth disease in cattle
publisher	Islamic Azad University, Tabriz Branch
publishDate	2021
url	https://doaj.org/article/5b11b2e077e14772a4639aabbe55db4e
work_keys_str_mv	AT mohammadtolouei clinicalevaluationoftheeffectofhydroalcoholicextractofhypericumperforatumonthehealingoforallesionsoffootandmouthdiseaseincattle AT amirdaneshvar clinicalevaluationoftheeffectofhydroalcoholicextractofhypericumperforatumonthehealingoforallesionsoffootandmouthdiseaseincattle AT hoseintayefinasrabadi clinicalevaluationoftheeffectofhydroalcoholicextractofhypericumperforatumonthehealingoforallesionsoffootandmouthdiseaseincattle AT omidmadadgar clinicalevaluationoftheeffectofhydroalcoholicextractofhypericumperforatumonthehealingoforallesionsoffootandmouthdiseaseincattle
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Clinical evaluation of the effect of hydroalcoholic extract of Hypericum perforatum on the healing of oral lesions of Foot and mouth disease in cattle

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