METABOLIC STATE OF BLOOD LYMPHOCYTES IN CHRONIC MYELOID LEUKEMIA AND CHRONIC LYMPHOID LEUKEMIA

Abstract. We examined metabolic status of blood lymphocytes in forty-four patients with chronic myeloid leukemia (CML), and in fifty-seven patients with chronic lymphoid leukemia (CLL). The most pronounced changes of enzyme activities are found in blood lymphocytes of CML and CLL patients during ter...

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Autores principales:	O. V. Smirnova, V. T. Manchuk, A. A. Savchenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	metabolic processes in blood lymphocytes chronic lymphoid leukemia chronic myeloid leukemia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5b13727018d74d478840df4ae4f9a0a1
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spelling	oai:doaj.org-article:5b13727018d74d478840df4ae4f9a0a12021-11-18T08:03:37ZMETABOLIC STATE OF BLOOD LYMPHOCYTES IN CHRONIC MYELOID LEUKEMIA AND CHRONIC LYMPHOID LEUKEMIA1563-06252313-741X10.15789/1563-0625-2008-1-21-26https://doaj.org/article/5b13727018d74d478840df4ae4f9a0a12014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/74https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We examined metabolic status of blood lymphocytes in forty-four patients with chronic myeloid leukemia (CML), and in fifty-seven patients with chronic lymphoid leukemia (CLL). The most pronounced changes of enzyme activities are found in blood lymphocytes of CML and CLL patients during terminal stage of the disease. All the patients with chronic leukemia at both stages showed a decreased intensity of metabolic processes in blood lymphocytes. In addition, CML patients at both clinical stages exhibited a decrease in antioxidant cell protection. The more pronounced biochemical disturbances in CML patients at progression stage concerned carbohydrate metabolism, whereas the changes at terminal stage of disease affected both carbohydrate and fat metabolism. The most marked biochemical alterations in CLL at progression stage are registered for carbohydrate and protein metabolism, and carbohydrate, fat and protein metabolism at terminal stage of disease. The revealed changes showed indicate to more severe clinical course in the patients with CML. These changes and differences depict some aspects of immune pathogenesis in development and progression of CML and CLL.O. V. SmirnovaV. T. ManchukA. A. SavchenkoSPb RAACIarticlemetabolic processes in blood lymphocyteschronic lymphoid leukemiachronic myeloid leukemiaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 1, Pp 21-26 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	metabolic processes in blood lymphocytes chronic lymphoid leukemia chronic myeloid leukemia Immunologic diseases. Allergy RC581-607
spellingShingle	metabolic processes in blood lymphocytes chronic lymphoid leukemia chronic myeloid leukemia Immunologic diseases. Allergy RC581-607 O. V. Smirnova V. T. Manchuk A. A. Savchenko METABOLIC STATE OF BLOOD LYMPHOCYTES IN CHRONIC MYELOID LEUKEMIA AND CHRONIC LYMPHOID LEUKEMIA
description	Abstract. We examined metabolic status of blood lymphocytes in forty-four patients with chronic myeloid leukemia (CML), and in fifty-seven patients with chronic lymphoid leukemia (CLL). The most pronounced changes of enzyme activities are found in blood lymphocytes of CML and CLL patients during terminal stage of the disease. All the patients with chronic leukemia at both stages showed a decreased intensity of metabolic processes in blood lymphocytes. In addition, CML patients at both clinical stages exhibited a decrease in antioxidant cell protection. The more pronounced biochemical disturbances in CML patients at progression stage concerned carbohydrate metabolism, whereas the changes at terminal stage of disease affected both carbohydrate and fat metabolism. The most marked biochemical alterations in CLL at progression stage are registered for carbohydrate and protein metabolism, and carbohydrate, fat and protein metabolism at terminal stage of disease. The revealed changes showed indicate to more severe clinical course in the patients with CML. These changes and differences depict some aspects of immune pathogenesis in development and progression of CML and CLL.
format	article
author	O. V. Smirnova V. T. Manchuk A. A. Savchenko
author_facet	O. V. Smirnova V. T. Manchuk A. A. Savchenko
author_sort	O. V. Smirnova
title	METABOLIC STATE OF BLOOD LYMPHOCYTES IN CHRONIC MYELOID LEUKEMIA AND CHRONIC LYMPHOID LEUKEMIA
title_short	METABOLIC STATE OF BLOOD LYMPHOCYTES IN CHRONIC MYELOID LEUKEMIA AND CHRONIC LYMPHOID LEUKEMIA
title_full	METABOLIC STATE OF BLOOD LYMPHOCYTES IN CHRONIC MYELOID LEUKEMIA AND CHRONIC LYMPHOID LEUKEMIA
title_fullStr	METABOLIC STATE OF BLOOD LYMPHOCYTES IN CHRONIC MYELOID LEUKEMIA AND CHRONIC LYMPHOID LEUKEMIA
title_full_unstemmed	METABOLIC STATE OF BLOOD LYMPHOCYTES IN CHRONIC MYELOID LEUKEMIA AND CHRONIC LYMPHOID LEUKEMIA
title_sort	metabolic state of blood lymphocytes in chronic myeloid leukemia and chronic lymphoid leukemia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/5b13727018d74d478840df4ae4f9a0a1
work_keys_str_mv	AT ovsmirnova metabolicstateofbloodlymphocytesinchronicmyeloidleukemiaandchroniclymphoidleukemia AT vtmanchuk metabolicstateofbloodlymphocytesinchronicmyeloidleukemiaandchroniclymphoidleukemia AT aasavchenko metabolicstateofbloodlymphocytesinchronicmyeloidleukemiaandchroniclymphoidleukemia
_version_	1718422545174102016

METABOLIC STATE OF BLOOD LYMPHOCYTES IN CHRONIC MYELOID LEUKEMIA AND CHRONIC LYMPHOID LEUKEMIA

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