Supplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats

Abstract The high-fat diet (HFD) stimulates an increase in lipids and can be prejudicial for harmful to prostatic morphogenesis. Polyunsaturated fatty acid (PUFAs) have anti-inflammatory and antioxidant action in some types of cancer. The combination of aerobic physical exercise and PUFA can be more...

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Autores principales:	Allice Santos Cruz Veras, Rayana Loch Gomes, Maria Eduarda Almeida Tavares, Inês Cristina Giometti, Ana Paula Mattoso Miskulin Cardoso, Beatriz da Costa Aguiar Alves, Sabrina Alves Lenquiste, Luiz Carlos Marques Vanderlei, Giovana Rampazzo Teixeira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5b13e9001be14168aabba33ab4b72a45
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spelling	oai:doaj.org-article:5b13e9001be14168aabba33ab4b72a452021-12-02T11:39:27ZSupplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats10.1038/s41598-021-85337-92045-2322https://doaj.org/article/5b13e9001be14168aabba33ab4b72a452021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85337-9https://doaj.org/toc/2045-2322Abstract The high-fat diet (HFD) stimulates an increase in lipids and can be prejudicial for harmful to prostatic morphogenesis. Polyunsaturated fatty acid (PUFAs) have anti-inflammatory and antioxidant action in some types of cancer. The combination of aerobic physical exercise and PUFA can be more effective and reduce the risk of death. The study evaluates the effects of aerobic physical exercise associated with omega-3 (fish and chia oils), on the ventral prostate of Wistar rats those fed with HFD. Here, we report that HFD modified the final body weight and the weight gain, decreased the expression of the androgen receptor and increased prostatic inflammation via TNF-α produced damage prostatic like intraepithelial neoplasia. The supplementation with fish oil decreases final body weight, reduced BCL-2 and inflammation compared to chia oil; aerobic physical exercise associated with fish oil reduced lipids circulant and prostatic, increased proteins pro-apoptotic expression and reduced IL-6 (p < 0.0001) and TNF-α potentiating the CAT (p = 0.03) and SOD-1 (p = 0.001) expression. Additionally, the chia oil increased the NRF-2 (p < 0.0001) and GSS (p = 0.4) genes. PUFAs reduced the damage caused by excessive high-fat diet in the prostate so that there is greater effectiveness in omega-3 intake, it is necessary to associate with aerobic physical exercise.Allice Santos Cruz VerasRayana Loch GomesMaria Eduarda Almeida TavaresInês Cristina GiomettiAna Paula Mattoso Miskulin CardosoBeatriz da Costa Aguiar AlvesSabrina Alves LenquisteLuiz Carlos Marques VanderleiGiovana Rampazzo TeixeiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Allice Santos Cruz Veras Rayana Loch Gomes Maria Eduarda Almeida Tavares Inês Cristina Giometti Ana Paula Mattoso Miskulin Cardoso Beatriz da Costa Aguiar Alves Sabrina Alves Lenquiste Luiz Carlos Marques Vanderlei Giovana Rampazzo Teixeira Supplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats
description	Abstract The high-fat diet (HFD) stimulates an increase in lipids and can be prejudicial for harmful to prostatic morphogenesis. Polyunsaturated fatty acid (PUFAs) have anti-inflammatory and antioxidant action in some types of cancer. The combination of aerobic physical exercise and PUFA can be more effective and reduce the risk of death. The study evaluates the effects of aerobic physical exercise associated with omega-3 (fish and chia oils), on the ventral prostate of Wistar rats those fed with HFD. Here, we report that HFD modified the final body weight and the weight gain, decreased the expression of the androgen receptor and increased prostatic inflammation via TNF-α produced damage prostatic like intraepithelial neoplasia. The supplementation with fish oil decreases final body weight, reduced BCL-2 and inflammation compared to chia oil; aerobic physical exercise associated with fish oil reduced lipids circulant and prostatic, increased proteins pro-apoptotic expression and reduced IL-6 (p < 0.0001) and TNF-α potentiating the CAT (p = 0.03) and SOD-1 (p = 0.001) expression. Additionally, the chia oil increased the NRF-2 (p < 0.0001) and GSS (p = 0.4) genes. PUFAs reduced the damage caused by excessive high-fat diet in the prostate so that there is greater effectiveness in omega-3 intake, it is necessary to associate with aerobic physical exercise.
format	article
author	Allice Santos Cruz Veras Rayana Loch Gomes Maria Eduarda Almeida Tavares Inês Cristina Giometti Ana Paula Mattoso Miskulin Cardoso Beatriz da Costa Aguiar Alves Sabrina Alves Lenquiste Luiz Carlos Marques Vanderlei Giovana Rampazzo Teixeira
author_facet	Allice Santos Cruz Veras Rayana Loch Gomes Maria Eduarda Almeida Tavares Inês Cristina Giometti Ana Paula Mattoso Miskulin Cardoso Beatriz da Costa Aguiar Alves Sabrina Alves Lenquiste Luiz Carlos Marques Vanderlei Giovana Rampazzo Teixeira
author_sort	Allice Santos Cruz Veras
title	Supplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats
title_short	Supplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats
title_full	Supplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats
title_fullStr	Supplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats
title_full_unstemmed	Supplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats
title_sort	supplementation of polyunsaturated fatty acids (pufas) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5b13e9001be14168aabba33ab4b72a45
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Supplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats

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