Features of redox homeostasis in patients with liver cirrhosis (literature review and clinical case description)

Aim. To review the literature devoted to the study of redox homeostasis in patients with liver cirrhosis, and to describe the clinical case from practice. Material and Methods. The content analysis, method of systematic and comparative analysis, and bibliosemantic method of studying relevant rese...

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Autores principales:	M.O. Abrahamovych, O.O. Abrahamovych, O.P. Fayura, L.R. Fayura
Formato:	article
Lenguaje:	EN UK
Publicado:	Danylo Halytsky Lviv National Medical University 2020
Materias:	cirrhosis, endothelial dysfunction, oxidative stress, antioxidants, portal hypertension Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5b1507ae8f1e429d81096e1fd850ab35
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spelling	oai:doaj.org-article:5b1507ae8f1e429d81096e1fd850ab352021-11-10T19:49:51ZFeatures of redox homeostasis in patients with liver cirrhosis (literature review and clinical case description)1029-42442415-330310.25040/aml2020.01.070https://doaj.org/article/5b1507ae8f1e429d81096e1fd850ab352020-02-01T00:00:00Zhttps://amljournal.com/index.php/journal/article/view/43https://doaj.org/toc/1029-4244https://doaj.org/toc/2415-3303Aim. To review the literature devoted to the study of redox homeostasis in patients with liver cirrhosis, and to describe the clinical case from practice. Material and Methods. The content analysis, method of systematic and comparative analysis, and bibliosemantic method of studying relevant research concerning the state of redox homeostasis in patients with liver cirrhosis were used. The data was searched in the following research databases: PubMed, Medline, Springer, Google Scholar, Research Gate by keywords: liver cirrhosis, redox homeostasis, endothelial dysfunction, oxidative stress, antioxidants, portal hypertension. As many as 143 English and Ukrainian sources were analyzed. The sources highlighting the features of redox homeostasis in patients with liver cirrhosis were selected. A clinical case is described. Results and Discussion. The review of the current literature and the description of the clinical case suggest that under the influence of alcohol, hepatitis B and C, medicines, etc., an imbalance occurs in the system of prooxidants-antioxidants, causing multiple molecular and biochemical changes in the liver and nervous system due to changes in L-arginine, nitric oxide, endothelin metabolism, as well as synthesis, activation, and deactivation of cytokines, lipid peroxidation products, adhesion molecules, pro-, anticoagulation factors, and immune complexes, which increases the disease severity. The revealed role of oxidative stress, in turn, urges us to use medicines with antioxidant properties for treatment of patients with liver cirrhosis. Conclusions. Under the influence of a number of etiologic factors of the liver cirrhosis onset, there is the disturbance of redox homeostasis, which causes endothelial dysfunction and leads to an imbalance of the autonomic nervous system and increases the disease severity, which causes us to use medicines with antioxidant properties in the treatment.M.O. AbrahamovychO.O. AbrahamovychO.P. FayuraL.R. FayuraDanylo Halytsky Lviv National Medical Universityarticlecirrhosis, endothelial dysfunction, oxidative stress, antioxidants, portal hypertensionMedicine (General)R5-920ENUKActa Medica Leopoliensia, Vol 26, Iss 1, Pp 70-86 (2020)
institution	DOAJ
collection	DOAJ
language	EN UK
topic	cirrhosis, endothelial dysfunction, oxidative stress, antioxidants, portal hypertension Medicine (General) R5-920
spellingShingle	cirrhosis, endothelial dysfunction, oxidative stress, antioxidants, portal hypertension Medicine (General) R5-920 M.O. Abrahamovych O.O. Abrahamovych O.P. Fayura L.R. Fayura Features of redox homeostasis in patients with liver cirrhosis (literature review and clinical case description)
description	Aim. To review the literature devoted to the study of redox homeostasis in patients with liver cirrhosis, and to describe the clinical case from practice. Material and Methods. The content analysis, method of systematic and comparative analysis, and bibliosemantic method of studying relevant research concerning the state of redox homeostasis in patients with liver cirrhosis were used. The data was searched in the following research databases: PubMed, Medline, Springer, Google Scholar, Research Gate by keywords: liver cirrhosis, redox homeostasis, endothelial dysfunction, oxidative stress, antioxidants, portal hypertension. As many as 143 English and Ukrainian sources were analyzed. The sources highlighting the features of redox homeostasis in patients with liver cirrhosis were selected. A clinical case is described. Results and Discussion. The review of the current literature and the description of the clinical case suggest that under the influence of alcohol, hepatitis B and C, medicines, etc., an imbalance occurs in the system of prooxidants-antioxidants, causing multiple molecular and biochemical changes in the liver and nervous system due to changes in L-arginine, nitric oxide, endothelin metabolism, as well as synthesis, activation, and deactivation of cytokines, lipid peroxidation products, adhesion molecules, pro-, anticoagulation factors, and immune complexes, which increases the disease severity. The revealed role of oxidative stress, in turn, urges us to use medicines with antioxidant properties for treatment of patients with liver cirrhosis. Conclusions. Under the influence of a number of etiologic factors of the liver cirrhosis onset, there is the disturbance of redox homeostasis, which causes endothelial dysfunction and leads to an imbalance of the autonomic nervous system and increases the disease severity, which causes us to use medicines with antioxidant properties in the treatment.
format	article
author	M.O. Abrahamovych O.O. Abrahamovych O.P. Fayura L.R. Fayura
author_facet	M.O. Abrahamovych O.O. Abrahamovych O.P. Fayura L.R. Fayura
author_sort	M.O. Abrahamovych
title	Features of redox homeostasis in patients with liver cirrhosis (literature review and clinical case description)
title_short	Features of redox homeostasis in patients with liver cirrhosis (literature review and clinical case description)
title_full	Features of redox homeostasis in patients with liver cirrhosis (literature review and clinical case description)
title_fullStr	Features of redox homeostasis in patients with liver cirrhosis (literature review and clinical case description)
title_full_unstemmed	Features of redox homeostasis in patients with liver cirrhosis (literature review and clinical case description)
title_sort	features of redox homeostasis in patients with liver cirrhosis (literature review and clinical case description)
publisher	Danylo Halytsky Lviv National Medical University
publishDate	2020
url	https://doaj.org/article/5b1507ae8f1e429d81096e1fd850ab35
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Features of redox homeostasis in patients with liver cirrhosis (literature review and clinical case description)

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