Time–frequency analysis of serum with proton nuclear magnetic resonance for diagnosis of pancreatic cancer

Abstract Although serum markers such as carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) have been widely used in screening for pancreatic cancer (PC), their sensitivity and specificity are unsatisfactory. Recently, a novel tool of analyzing serum using the short-time Fourier transfo...

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Autores principales:	Asahi Sato, Toshihiko Masui, Akitada Yogo, Takashi Ito, Keiko Hirakawa, Yoshimasa Kanawaku, Kaoru Koike, Shinji Uemoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5b156c0aaab740d2b63fc33b5d66451f
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spelling	oai:doaj.org-article:5b156c0aaab740d2b63fc33b5d66451f2021-12-02T11:57:56ZTime–frequency analysis of serum with proton nuclear magnetic resonance for diagnosis of pancreatic cancer10.1038/s41598-020-79087-32045-2322https://doaj.org/article/5b156c0aaab740d2b63fc33b5d66451f2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79087-3https://doaj.org/toc/2045-2322Abstract Although serum markers such as carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) have been widely used in screening for pancreatic cancer (PC), their sensitivity and specificity are unsatisfactory. Recently, a novel tool of analyzing serum using the short-time Fourier transform (STFT) of free induction decays (FIDs) obtained by 1H-NMR has been introduced. We for the first time evaluated the utility of this technology as a diagnostic tool for PC. Serum was obtained from PC patients before starting any treatments. Samples taken from individuals with benign diseases or donors for liver transplantation were obtained as controls. Serum samples from both groups underwent 1H-NMR and STFT of FIDs. STFT data were analyzed by partial least squares discriminant analysis (PLS-DA) to clarify whether differences were apparent between groups. As a result, PLS-DA score plots indicated that STFT of FIDs enabled effective classification of groups with and without PC. Additionally, in a subgroup of PC, long-term survivors (≥ 2 years) could be discriminated from short-term survivors (< 2 years), regardless of pathologic stage or CEA or CA19-9 levels. In conclusion, STFT of FIDs obtained from 1H-NMR have a potential to be a diagnostic and prognostic tool of PC.Asahi SatoToshihiko MasuiAkitada YogoTakashi ItoKeiko HirakawaYoshimasa KanawakuKaoru KoikeShinji UemotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Asahi Sato Toshihiko Masui Akitada Yogo Takashi Ito Keiko Hirakawa Yoshimasa Kanawaku Kaoru Koike Shinji Uemoto Time–frequency analysis of serum with proton nuclear magnetic resonance for diagnosis of pancreatic cancer
description	Abstract Although serum markers such as carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) have been widely used in screening for pancreatic cancer (PC), their sensitivity and specificity are unsatisfactory. Recently, a novel tool of analyzing serum using the short-time Fourier transform (STFT) of free induction decays (FIDs) obtained by 1H-NMR has been introduced. We for the first time evaluated the utility of this technology as a diagnostic tool for PC. Serum was obtained from PC patients before starting any treatments. Samples taken from individuals with benign diseases or donors for liver transplantation were obtained as controls. Serum samples from both groups underwent 1H-NMR and STFT of FIDs. STFT data were analyzed by partial least squares discriminant analysis (PLS-DA) to clarify whether differences were apparent between groups. As a result, PLS-DA score plots indicated that STFT of FIDs enabled effective classification of groups with and without PC. Additionally, in a subgroup of PC, long-term survivors (≥ 2 years) could be discriminated from short-term survivors (< 2 years), regardless of pathologic stage or CEA or CA19-9 levels. In conclusion, STFT of FIDs obtained from 1H-NMR have a potential to be a diagnostic and prognostic tool of PC.
format	article
author	Asahi Sato Toshihiko Masui Akitada Yogo Takashi Ito Keiko Hirakawa Yoshimasa Kanawaku Kaoru Koike Shinji Uemoto
author_facet	Asahi Sato Toshihiko Masui Akitada Yogo Takashi Ito Keiko Hirakawa Yoshimasa Kanawaku Kaoru Koike Shinji Uemoto
author_sort	Asahi Sato
title	Time–frequency analysis of serum with proton nuclear magnetic resonance for diagnosis of pancreatic cancer
title_short	Time–frequency analysis of serum with proton nuclear magnetic resonance for diagnosis of pancreatic cancer
title_full	Time–frequency analysis of serum with proton nuclear magnetic resonance for diagnosis of pancreatic cancer
title_fullStr	Time–frequency analysis of serum with proton nuclear magnetic resonance for diagnosis of pancreatic cancer
title_full_unstemmed	Time–frequency analysis of serum with proton nuclear magnetic resonance for diagnosis of pancreatic cancer
title_sort	time–frequency analysis of serum with proton nuclear magnetic resonance for diagnosis of pancreatic cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5b156c0aaab740d2b63fc33b5d66451f
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Time–frequency analysis of serum with proton nuclear magnetic resonance for diagnosis of pancreatic cancer

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