Short-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis

Short-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis

Jun N-terminal kinase (JNK) is necessary for development in tumours, indicating it may play tumour-promoting roles; however, the experimental analysis of the role of JNK in proliferation is hindered by its pro-apoptotic activity. Here the authors carry out experiments in Drosophila with genetic back...

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Autores principales: Noelia Pinal, María Martín, Izarne Medina, Ginés Morata
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5b1a8fce74a740de91bcf75edb07ca12
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spelling oai:doaj.org-article:5b1a8fce74a740de91bcf75edb07ca122021-12-02T14:39:08ZShort-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis10.1038/s41467-018-04000-62041-1723https://doaj.org/article/5b1a8fce74a740de91bcf75edb07ca122018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04000-6https://doaj.org/toc/2041-1723Jun N-terminal kinase (JNK) is necessary for development in tumours, indicating it may play tumour-promoting roles; however, the experimental analysis of the role of JNK in proliferation is hindered by its pro-apoptotic activity. Here the authors carry out experiments in Drosophila with genetic backgrounds that make cells refractory to apoptosis to definitely prove the JNK pathway contribution to tumorigenesis.Noelia PinalMaría MartínIzarne MedinaGinés MorataNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Noelia Pinal
María Martín
Izarne Medina
Ginés Morata
Short-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis
description Jun N-terminal kinase (JNK) is necessary for development in tumours, indicating it may play tumour-promoting roles; however, the experimental analysis of the role of JNK in proliferation is hindered by its pro-apoptotic activity. Here the authors carry out experiments in Drosophila with genetic backgrounds that make cells refractory to apoptosis to definitely prove the JNK pathway contribution to tumorigenesis.
format article
author Noelia Pinal
María Martín
Izarne Medina
Ginés Morata
author_facet Noelia Pinal
María Martín
Izarne Medina
Ginés Morata
author_sort Noelia Pinal
title Short-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis
title_short Short-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis
title_full Short-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis
title_fullStr Short-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis
title_full_unstemmed Short-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis
title_sort short-term activation of the jun n-terminal kinase pathway in apoptosis-deficient cells of drosophila induces tumorigenesis
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/5b1a8fce74a740de91bcf75edb07ca12
work_keys_str_mv AT noeliapinal shorttermactivationofthejunnterminalkinasepathwayinapoptosisdeficientcellsofdrosophilainducestumorigenesis
AT mariamartin shorttermactivationofthejunnterminalkinasepathwayinapoptosisdeficientcellsofdrosophilainducestumorigenesis
AT izarnemedina shorttermactivationofthejunnterminalkinasepathwayinapoptosisdeficientcellsofdrosophilainducestumorigenesis
AT ginesmorata shorttermactivationofthejunnterminalkinasepathwayinapoptosisdeficientcellsofdrosophilainducestumorigenesis
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