CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Abstract. We studied cytokine profile in blood and exhaled breath condensate (EBC) in patients with chronic obstructive pulmonary disease (COPD) being in remission state. It is shown that pro- and anti-inflammatory cytokine contents depended on the disease severity, both in whole blood and EBC of th...
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SPb RAACI
2014
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oai:doaj.org-article:5b1e1272faee4c848fa4d57ac794bcb52021-11-18T08:03:43ZCYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE1563-06252313-741X10.15789/1563-0625-2012-6-501-506https://doaj.org/article/5b1e1272faee4c848fa4d57ac794bcb52014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/590https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We studied cytokine profile in blood and exhaled breath condensate (EBC) in patients with chronic obstructive pulmonary disease (COPD) being in remission state. It is shown that pro- and anti-inflammatory cytokine contents depended on the disease severity, both in whole blood and EBC of the COPD patients. We have revealed an increase in TNFα, s-TNFα RI, TGF-β1 and bFGF in EBC of patients with COPD manifestations, thus being indicative for progression of metabolic changes in lung tissue, and advanced stage of respiratory functional disturbances. Cytokine profile abnormalities in COPD patients resulting, in part, from systemic and local disorders of cellular immunity, represent a major pathogenetic mechanism determining the disease progression.E. Р. KalininaЕ. Г. ЛобановаSPb RAACIarticlechronic obstructive pulmonary diseasecytokine profilerespiratory functionmetabolic changesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 6, Pp 501-506 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
RU |
| topic |
chronic obstructive pulmonary disease cytokine profile respiratory function metabolic changes Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
chronic obstructive pulmonary disease cytokine profile respiratory function metabolic changes Immunologic diseases. Allergy RC581-607 E. Р. Kalinina Е. Г. Лобанова CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| description |
Abstract. We studied cytokine profile in blood and exhaled breath condensate (EBC) in patients with chronic obstructive pulmonary disease (COPD) being in remission state. It is shown that pro- and anti-inflammatory cytokine contents depended on the disease severity, both in whole blood and EBC of the COPD patients. We have revealed an increase in TNFα, s-TNFα RI, TGF-β1 and bFGF in EBC of patients with COPD manifestations, thus being indicative for progression of metabolic changes in lung tissue, and advanced stage of respiratory functional disturbances. Cytokine profile abnormalities in COPD patients resulting, in part, from systemic and local disorders of cellular immunity, represent a major pathogenetic mechanism determining the disease progression. |
| format |
article |
| author |
E. Р. Kalinina Е. Г. Лобанова |
| author_facet |
E. Р. Kalinina Е. Г. Лобанова |
| author_sort |
E. Р. Kalinina |
| title |
CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_short |
CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_full |
CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_fullStr |
CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_full_unstemmed |
CYTOKINE PROFILE FEATURES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| title_sort |
cytokine profile features in patients with chronic obstructive pulmonary disease |
| publisher |
SPb RAACI |
| publishDate |
2014 |
| url |
https://doaj.org/article/5b1e1272faee4c848fa4d57ac794bcb5 |
| work_keys_str_mv |
AT erkalinina cytokineprofilefeaturesinpatientswithchronicobstructivepulmonarydisease AT eglobanova cytokineprofilefeaturesinpatientswithchronicobstructivepulmonarydisease |
| _version_ |
1718422418768265216 |