Effect of different doses of statins on the development of type 2 diabetes mellitus in patients with myocardial infarction

Olga Gruzdeva,1 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Akbasheva,2 Victoria Karetnikova,1 Aleksandr Shilov,1 Olga Barbarash1 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia; 2State Budget Educational Institution of Higher Profe...

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Autores principales:	Gruzdeva O, Uchasova E, Dyleva Y, Akbasheva O, Karetnikova V, Shilov A, Barbarash O
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	statin myocardial infarction inflammation adipokine resistin Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/5b2045d927034a9abb9b9ecad78e9f26
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spelling	oai:doaj.org-article:5b2045d927034a9abb9b9ecad78e9f262021-12-02T02:50:02ZEffect of different doses of statins on the development of type 2 diabetes mellitus in patients with myocardial infarction1178-7007https://doaj.org/article/5b2045d927034a9abb9b9ecad78e9f262017-12-01T00:00:00Zhttps://www.dovepress.com/effect-of-different-doses-of-statins-on-the-development-of-type-2-diab-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Olga Gruzdeva,1 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Akbasheva,2 Victoria Karetnikova,1 Aleksandr Shilov,1 Olga Barbarash1 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia; 2State Budget Educational Institution of Higher Professional Education, Siberian State Medical University, Russian Federation Ministry of Health, Tomsk, Russia Background: Cardiovascular diseases and type 2 diabetes mellitus (T2DM) may have common developmental mechanisms associated with lipid metabolism disorders. Dyslipidemia and progression of atherosclerosis in people with T2DM are accompanied by an increase in cardiovascular mortality. This study examined the dose-dependent action of atorvastatin on carbohydrate metabolism and adipokine status in patients within 12 months after myocardial infarction (MI).Methods: A total of 156 male MI patients who had received atorvastatin 20 mg/day (78 patients) or 40 mg/day (78 patients) starting from day 1 of onset were enrolled. Glucose, insulin, C-peptide, resistin, adiponectin, and ghrelin levels were measured at baseline, day 12, and months 3 and 12. Patients were monitored for new incidences of T2DM for 12 months after MI.Results: For acute phase MI, patients had moderate insulin resistance, hyperglycemia, and hyperinsulinemia, high leptin and resistin levels, and low ghrelin and adiponectin levels. Atorvastatin 20 mg/day was more effective at correcting the imbalances. Patients taking atorvastatin 40 mg/day (group 2) following MI showed increases in levels of glucose, insulin, and C-peptide and insulin resistance progression after 12 months of therapy, as evidenced by increased quantitative insulin sensitivity check index scores and detection of new T2DM cases.Conclusion: Atorvastatin improved adipokine profiles and ghrelin levels, with low doses showing more significant effects. Atorvastatin dose prescribed for MI patients should take into account the degree of insulin resistance and adipokine status. Keywords: statin, myocardial infarction, inflammation, adipokine, resistinGruzdeva OUchasova EDyleva YAkbasheva OKaretnikova VShilov ABarbarash ODove Medical Pressarticlestatinmyocardial infarctioninflammationadipokineresistinSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 10, Pp 481-489 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	statin myocardial infarction inflammation adipokine resistin Specialties of internal medicine RC581-951
spellingShingle	statin myocardial infarction inflammation adipokine resistin Specialties of internal medicine RC581-951 Gruzdeva O Uchasova E Dyleva Y Akbasheva O Karetnikova V Shilov A Barbarash O Effect of different doses of statins on the development of type 2 diabetes mellitus in patients with myocardial infarction
description	Olga Gruzdeva,1 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Akbasheva,2 Victoria Karetnikova,1 Aleksandr Shilov,1 Olga Barbarash1 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia; 2State Budget Educational Institution of Higher Professional Education, Siberian State Medical University, Russian Federation Ministry of Health, Tomsk, Russia Background: Cardiovascular diseases and type 2 diabetes mellitus (T2DM) may have common developmental mechanisms associated with lipid metabolism disorders. Dyslipidemia and progression of atherosclerosis in people with T2DM are accompanied by an increase in cardiovascular mortality. This study examined the dose-dependent action of atorvastatin on carbohydrate metabolism and adipokine status in patients within 12 months after myocardial infarction (MI).Methods: A total of 156 male MI patients who had received atorvastatin 20 mg/day (78 patients) or 40 mg/day (78 patients) starting from day 1 of onset were enrolled. Glucose, insulin, C-peptide, resistin, adiponectin, and ghrelin levels were measured at baseline, day 12, and months 3 and 12. Patients were monitored for new incidences of T2DM for 12 months after MI.Results: For acute phase MI, patients had moderate insulin resistance, hyperglycemia, and hyperinsulinemia, high leptin and resistin levels, and low ghrelin and adiponectin levels. Atorvastatin 20 mg/day was more effective at correcting the imbalances. Patients taking atorvastatin 40 mg/day (group 2) following MI showed increases in levels of glucose, insulin, and C-peptide and insulin resistance progression after 12 months of therapy, as evidenced by increased quantitative insulin sensitivity check index scores and detection of new T2DM cases.Conclusion: Atorvastatin improved adipokine profiles and ghrelin levels, with low doses showing more significant effects. Atorvastatin dose prescribed for MI patients should take into account the degree of insulin resistance and adipokine status. Keywords: statin, myocardial infarction, inflammation, adipokine, resistin
format	article
author	Gruzdeva O Uchasova E Dyleva Y Akbasheva O Karetnikova V Shilov A Barbarash O
author_facet	Gruzdeva O Uchasova E Dyleva Y Akbasheva O Karetnikova V Shilov A Barbarash O
author_sort	Gruzdeva O
title	Effect of different doses of statins on the development of type 2 diabetes mellitus in patients with myocardial infarction
title_short	Effect of different doses of statins on the development of type 2 diabetes mellitus in patients with myocardial infarction
title_full	Effect of different doses of statins on the development of type 2 diabetes mellitus in patients with myocardial infarction
title_fullStr	Effect of different doses of statins on the development of type 2 diabetes mellitus in patients with myocardial infarction
title_full_unstemmed	Effect of different doses of statins on the development of type 2 diabetes mellitus in patients with myocardial infarction
title_sort	effect of different doses of statins on the development of type 2 diabetes mellitus in patients with myocardial infarction
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/5b2045d927034a9abb9b9ecad78e9f26
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Effect of different doses of statins on the development of type 2 diabetes mellitus in patients with myocardial infarction

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