Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy
Mohamed M Khodeiry,1,2 Xiangxiang Liu,1,3 Mohamed S Sayed,1 Raquel Goldhardt,1 Giovanni Gregori,1 Thomas A Albini,1 Richard K Lee1 1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA; 2Research Institute of Ophthalmology, De...
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Dove Medical Press
2021
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oai:doaj.org-article:5b2154464a0b4beda14c5516a92f6f392021-12-02T14:54:26ZPeripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy1177-5483https://doaj.org/article/5b2154464a0b4beda14c5516a92f6f392021-06-01T00:00:00Zhttps://www.dovepress.com/peripapillary-halo-in-inflammatory-papillitis-of-birdshot-chorioretino-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Mohamed M Khodeiry,1,2 Xiangxiang Liu,1,3 Mohamed S Sayed,1 Raquel Goldhardt,1 Giovanni Gregori,1 Thomas A Albini,1 Richard K Lee1 1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA; 2Research Institute of Ophthalmology, Department of Ophthalmology, Giza, 12557, Egypt; 3Beijing Eye Institute, Beijing Tongren Eye Center, Beijing Tongren Eye Hospital, Capital Medical University, Beijing, 100730, People’s Republic of ChinaCorrespondence: Richard K LeeBascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, 900 NW 17 th Street, Miami, FL 33136, USATel +1 305 326-6400Fax +1 305 547-3658Email rlee@med.miami.eduPurpose: Peripapillary halos (PPH) are peripapillary changes observed surrounding the optic nerve head in normal eyes and eyes with different disorders. Recognizing the microstructure and mechanism of development of these halos will help clinicians understand the different associated retinal and optic nerve head pathologies. We describe the in vivo histological characteristics of PPH in birdshot chorioretinopathy (BSCR).Patients and Methods: This was a prospective observational case-series in a single tertiary referral center. Six eyes of three patients with PPH associated with BSCR were determined through clinical examination, fundus photography, and fundus autofluorescence (FAF). Patients underwent swept-source optical coherence tomography (SS-OCT) imaging of the optic nerve head and peripapillary region.Results: In SS-OCT B-scans across the area of PPH, we observed thinning and interruption of retinal pigment epithelium (RPE)-Bruch’s membrane complex. These halos are a circumferential form of alpha zone RPE-associated crescentic peripapillary atrophy (PPA), unlike the PPH observed with myopia and normal aging.Conclusion: PPH in BSCR patients may be a sign of prior inflammatory optic neuropathy.Keywords: birdshot chorioretinitis, optical coherence tomography, optic nerve head, peripapillary halo, peripapillary atrophyKhodeiry MMLiu XSayed MSGoldhardt RGregori GAlbini TALee RKDove Medical Pressarticlebirdshot chorioretinitisoptical coherence tomographyoptic nerve headperipapillary haloperipapillary atrophyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 2327-2333 (2021) |
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birdshot chorioretinitis optical coherence tomography optic nerve head peripapillary halo peripapillary atrophy Ophthalmology RE1-994 |
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birdshot chorioretinitis optical coherence tomography optic nerve head peripapillary halo peripapillary atrophy Ophthalmology RE1-994 Khodeiry MM Liu X Sayed MS Goldhardt R Gregori G Albini TA Lee RK Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy |
| description |
Mohamed M Khodeiry,1,2 Xiangxiang Liu,1,3 Mohamed S Sayed,1 Raquel Goldhardt,1 Giovanni Gregori,1 Thomas A Albini,1 Richard K Lee1 1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA; 2Research Institute of Ophthalmology, Department of Ophthalmology, Giza, 12557, Egypt; 3Beijing Eye Institute, Beijing Tongren Eye Center, Beijing Tongren Eye Hospital, Capital Medical University, Beijing, 100730, People’s Republic of ChinaCorrespondence: Richard K LeeBascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, 900 NW 17 th Street, Miami, FL 33136, USATel +1 305 326-6400Fax +1 305 547-3658Email rlee@med.miami.eduPurpose: Peripapillary halos (PPH) are peripapillary changes observed surrounding the optic nerve head in normal eyes and eyes with different disorders. Recognizing the microstructure and mechanism of development of these halos will help clinicians understand the different associated retinal and optic nerve head pathologies. We describe the in vivo histological characteristics of PPH in birdshot chorioretinopathy (BSCR).Patients and Methods: This was a prospective observational case-series in a single tertiary referral center. Six eyes of three patients with PPH associated with BSCR were determined through clinical examination, fundus photography, and fundus autofluorescence (FAF). Patients underwent swept-source optical coherence tomography (SS-OCT) imaging of the optic nerve head and peripapillary region.Results: In SS-OCT B-scans across the area of PPH, we observed thinning and interruption of retinal pigment epithelium (RPE)-Bruch’s membrane complex. These halos are a circumferential form of alpha zone RPE-associated crescentic peripapillary atrophy (PPA), unlike the PPH observed with myopia and normal aging.Conclusion: PPH in BSCR patients may be a sign of prior inflammatory optic neuropathy.Keywords: birdshot chorioretinitis, optical coherence tomography, optic nerve head, peripapillary halo, peripapillary atrophy |
| format |
article |
| author |
Khodeiry MM Liu X Sayed MS Goldhardt R Gregori G Albini TA Lee RK |
| author_facet |
Khodeiry MM Liu X Sayed MS Goldhardt R Gregori G Albini TA Lee RK |
| author_sort |
Khodeiry MM |
| title |
Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy |
| title_short |
Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy |
| title_full |
Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy |
| title_fullStr |
Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy |
| title_full_unstemmed |
Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy |
| title_sort |
peripapillary halo in inflammatory papillitis of birdshot chorioretinopathy |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/5b2154464a0b4beda14c5516a92f6f39 |
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