Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping

Abstract The mechanical properties of brain tissue play a pivotal role in neurodevelopment and neurological disorders. Yet, at present, there is no consensus on how the different structural parts of the tissue contribute to its stiffness variations. Here, we have gathered depth-controlled indentatio...

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Autores principales:	Nelda Antonovaite, Steven V. Beekmans, Elly M. Hol, Wytse J. Wadman, Davide Iannuzzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5b22ffeb4a2d4bfb8160c64fa840b73a
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spelling	oai:doaj.org-article:5b22ffeb4a2d4bfb8160c64fa840b73a2021-12-02T15:07:58ZRegional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping10.1038/s41598-018-31035-y2045-2322https://doaj.org/article/5b22ffeb4a2d4bfb8160c64fa840b73a2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-31035-yhttps://doaj.org/toc/2045-2322Abstract The mechanical properties of brain tissue play a pivotal role in neurodevelopment and neurological disorders. Yet, at present, there is no consensus on how the different structural parts of the tissue contribute to its stiffness variations. Here, we have gathered depth-controlled indentation viscoelasticity maps of the hippocampus of acute horizontal live mouse brain slices. Our results confirm the highly viscoelestic nature of brain tissue. We further show that the mechanical properties are non-uniform and at least related to differences in morphological composition. Interestingly, areas with higher nuclear density appear to be softer than areas with lower nuclear density.Nelda AntonovaiteSteven V. BeekmansElly M. HolWytse J. WadmanDavide IannuzziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nelda Antonovaite Steven V. Beekmans Elly M. Hol Wytse J. Wadman Davide Iannuzzi Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
description	Abstract The mechanical properties of brain tissue play a pivotal role in neurodevelopment and neurological disorders. Yet, at present, there is no consensus on how the different structural parts of the tissue contribute to its stiffness variations. Here, we have gathered depth-controlled indentation viscoelasticity maps of the hippocampus of acute horizontal live mouse brain slices. Our results confirm the highly viscoelestic nature of brain tissue. We further show that the mechanical properties are non-uniform and at least related to differences in morphological composition. Interestingly, areas with higher nuclear density appear to be softer than areas with lower nuclear density.
format	article
author	Nelda Antonovaite Steven V. Beekmans Elly M. Hol Wytse J. Wadman Davide Iannuzzi
author_facet	Nelda Antonovaite Steven V. Beekmans Elly M. Hol Wytse J. Wadman Davide Iannuzzi
author_sort	Nelda Antonovaite
title	Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
title_short	Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
title_full	Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
title_fullStr	Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
title_full_unstemmed	Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
title_sort	regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5b22ffeb4a2d4bfb8160c64fa840b73a
work_keys_str_mv	AT neldaantonovaite regionalvariationsinstiffnessinlivemousebraintissuedeterminedbydepthcontrolledindentationmapping AT stevenvbeekmans regionalvariationsinstiffnessinlivemousebraintissuedeterminedbydepthcontrolledindentationmapping AT ellymhol regionalvariationsinstiffnessinlivemousebraintissuedeterminedbydepthcontrolledindentationmapping AT wytsejwadman regionalvariationsinstiffnessinlivemousebraintissuedeterminedbydepthcontrolledindentationmapping AT davideiannuzzi regionalvariationsinstiffnessinlivemousebraintissuedeterminedbydepthcontrolledindentationmapping
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Regional variations in stiffness in live mouse brain tissue determined by depth-controlled indentation mapping

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