Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation.

Radiation-induced heart disease (RIHD) is a long-term side effect of radiotherapy of intrathoracic, chest wall and breast tumors when radiation fields encompass all or part of the heart. Previous studies have shown that pentoxifylline (PTX) in combination with α-tocopherol reduced manifestations of...

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Autores principales:	Vijayalakshmi Sridharan, Preeti Tripathi, Sunil Sharma, Peter M Corry, Eduardo G Moros, Awantika Singh, Cesar M Compadre, Martin Hauer-Jensen, Marjan Boerma
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5b234c0c1bc84e30b0c71994d24e351c
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spelling	oai:doaj.org-article:5b234c0c1bc84e30b0c71994d24e351c2021-11-18T09:03:41ZEffects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation.1932-620310.1371/journal.pone.0068762https://doaj.org/article/5b234c0c1bc84e30b0c71994d24e351c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23894340/?tool=EBIhttps://doaj.org/toc/1932-6203Radiation-induced heart disease (RIHD) is a long-term side effect of radiotherapy of intrathoracic, chest wall and breast tumors when radiation fields encompass all or part of the heart. Previous studies have shown that pentoxifylline (PTX) in combination with α-tocopherol reduced manifestations of RIHD in rat models of local heart irradiation. The relative contribution of PTX and α-tocopherol to these beneficial effects are not known. This study examined the effects of PTX alone or in combination with tocotrienols, forms of vitamin E with potential potent radiation mitigation properties. Rats received localized X-irradiation of the heart with an image-guided irradiation technique. At 3 months after irradiation rats received oral treatment with vehicle, PTX, or PTX in combination with a tocotrienol-enriched formulation. At 6 months after irradiation, PTX-treated rats showed arrhythmia in 5 out of 14 animals. PTX alone or in combination with tocotrienols did not alter cardiac radiation fibrosis, left ventricular protein expression of the endothelial markers von Willebrand factor and neuregulin-1, or phosphorylation of the signal mediators Akt, Erk1/2, or PKCα. On the other hand, tocotrienols reduced cardiac numbers of mast cells and macrophages, but enhanced the expression of tissue factor. While this new rat model of localized heart irradiation does not support the use of PTX alone, the effects of tocotrienols on chronic manifestations of RIHD deserve further investigation.Vijayalakshmi SridharanPreeti TripathiSunil SharmaPeter M CorryEduardo G MorosAwantika SinghCesar M CompadreMartin Hauer-JensenMarjan BoermaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68762 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vijayalakshmi Sridharan Preeti Tripathi Sunil Sharma Peter M Corry Eduardo G Moros Awantika Singh Cesar M Compadre Martin Hauer-Jensen Marjan Boerma Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation.
description	Radiation-induced heart disease (RIHD) is a long-term side effect of radiotherapy of intrathoracic, chest wall and breast tumors when radiation fields encompass all or part of the heart. Previous studies have shown that pentoxifylline (PTX) in combination with α-tocopherol reduced manifestations of RIHD in rat models of local heart irradiation. The relative contribution of PTX and α-tocopherol to these beneficial effects are not known. This study examined the effects of PTX alone or in combination with tocotrienols, forms of vitamin E with potential potent radiation mitigation properties. Rats received localized X-irradiation of the heart with an image-guided irradiation technique. At 3 months after irradiation rats received oral treatment with vehicle, PTX, or PTX in combination with a tocotrienol-enriched formulation. At 6 months after irradiation, PTX-treated rats showed arrhythmia in 5 out of 14 animals. PTX alone or in combination with tocotrienols did not alter cardiac radiation fibrosis, left ventricular protein expression of the endothelial markers von Willebrand factor and neuregulin-1, or phosphorylation of the signal mediators Akt, Erk1/2, or PKCα. On the other hand, tocotrienols reduced cardiac numbers of mast cells and macrophages, but enhanced the expression of tissue factor. While this new rat model of localized heart irradiation does not support the use of PTX alone, the effects of tocotrienols on chronic manifestations of RIHD deserve further investigation.
format	article
author	Vijayalakshmi Sridharan Preeti Tripathi Sunil Sharma Peter M Corry Eduardo G Moros Awantika Singh Cesar M Compadre Martin Hauer-Jensen Marjan Boerma
author_facet	Vijayalakshmi Sridharan Preeti Tripathi Sunil Sharma Peter M Corry Eduardo G Moros Awantika Singh Cesar M Compadre Martin Hauer-Jensen Marjan Boerma
author_sort	Vijayalakshmi Sridharan
title	Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation.
title_short	Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation.
title_full	Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation.
title_fullStr	Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation.
title_full_unstemmed	Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation.
title_sort	effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5b234c0c1bc84e30b0c71994d24e351c
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Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation.

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