microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism

Autosomal dominant polycystic kidney disease (ADPKD) is a life-threatening genetic disease that leads to renal failure. Here Hajarniset al. show that miR-17 modulates cyst progression in ADPKD through metabolic reprogramming of mitochondria and its inhibition slows cyst development and improves rena...

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Autores principales:	Sachin Hajarnis, Ronak Lakhia, Matanel Yheskel, Darren Williams, Mehran Sorourian, Xueqing Liu, Karam Aboudehen, Shanrong Zhang, Kara Kersjes, Ryan Galasso, Jian Li, Vivek Kaimal, Steven Lockton, Scott Davis, Andrea Flaten, Joshua A. Johnson, William L. Holland, Christine M. Kusminski, Philipp E. Scherer, Peter C. Harris, Marie Trudel, Darren P. Wallace, Peter Igarashi, Edmund C. Lee, John R. Androsavich, Vishal Patel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b2531a29caa4303ae532695340657ca
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spelling	oai:doaj.org-article:5b2531a29caa4303ae532695340657ca2021-12-02T17:06:25ZmicroRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism10.1038/ncomms143952041-1723https://doaj.org/article/5b2531a29caa4303ae532695340657ca2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14395https://doaj.org/toc/2041-1723Autosomal dominant polycystic kidney disease (ADPKD) is a life-threatening genetic disease that leads to renal failure. Here Hajarniset al. show that miR-17 modulates cyst progression in ADPKD through metabolic reprogramming of mitochondria and its inhibition slows cyst development and improves renal functions.Sachin HajarnisRonak LakhiaMatanel YheskelDarren WilliamsMehran SorourianXueqing LiuKaram AboudehenShanrong ZhangKara KersjesRyan GalassoJian LiVivek KaimalSteven LocktonScott DavisAndrea FlatenJoshua A. JohnsonWilliam L. HollandChristine M. KusminskiPhilipp E. SchererPeter C. HarrisMarie TrudelDarren P. WallacePeter IgarashiEdmund C. LeeJohn R. AndrosavichVishal PatelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sachin Hajarnis Ronak Lakhia Matanel Yheskel Darren Williams Mehran Sorourian Xueqing Liu Karam Aboudehen Shanrong Zhang Kara Kersjes Ryan Galasso Jian Li Vivek Kaimal Steven Lockton Scott Davis Andrea Flaten Joshua A. Johnson William L. Holland Christine M. Kusminski Philipp E. Scherer Peter C. Harris Marie Trudel Darren P. Wallace Peter Igarashi Edmund C. Lee John R. Androsavich Vishal Patel microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
description	Autosomal dominant polycystic kidney disease (ADPKD) is a life-threatening genetic disease that leads to renal failure. Here Hajarniset al. show that miR-17 modulates cyst progression in ADPKD through metabolic reprogramming of mitochondria and its inhibition slows cyst development and improves renal functions.
format	article
author	Sachin Hajarnis Ronak Lakhia Matanel Yheskel Darren Williams Mehran Sorourian Xueqing Liu Karam Aboudehen Shanrong Zhang Kara Kersjes Ryan Galasso Jian Li Vivek Kaimal Steven Lockton Scott Davis Andrea Flaten Joshua A. Johnson William L. Holland Christine M. Kusminski Philipp E. Scherer Peter C. Harris Marie Trudel Darren P. Wallace Peter Igarashi Edmund C. Lee John R. Androsavich Vishal Patel
author_facet	Sachin Hajarnis Ronak Lakhia Matanel Yheskel Darren Williams Mehran Sorourian Xueqing Liu Karam Aboudehen Shanrong Zhang Kara Kersjes Ryan Galasso Jian Li Vivek Kaimal Steven Lockton Scott Davis Andrea Flaten Joshua A. Johnson William L. Holland Christine M. Kusminski Philipp E. Scherer Peter C. Harris Marie Trudel Darren P. Wallace Peter Igarashi Edmund C. Lee John R. Androsavich Vishal Patel
author_sort	Sachin Hajarnis
title	microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
title_short	microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
title_full	microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
title_fullStr	microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
title_full_unstemmed	microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
title_sort	microrna-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5b2531a29caa4303ae532695340657ca
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microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism

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