Parkinson’s Disease Is Associated With Dysregulation of Circulatory Levels of lncRNAs

Long non-coding RNAs (lncRNAs) have been recently reported to be involved in the pathoetiology of Parkinson’s disease (PD). Circulatory levels of lncRNAs might be used as markers for PD. In the present work, we measured expression levels of HULC, PVT1, MEG3, SPRY4-IT1, LINC-ROR and DSCAM-AS1 lncRNAs...

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Autores principales:	Kasra Honarmand Tamizkar, Pooneh Gorji, Mahdi Gholipour, Bashdar Mahmud Hussen, Mehrdokht Mazdeh, Solat Eslami, Mohammad Taheri, Soudeh Ghafouri-Fard
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Parkinson’s disease lncRNA HULC PVT1 MEG3 SPRY4-IT1 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5b25aab020b2416181aeda2ce3df7746
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spelling	oai:doaj.org-article:5b25aab020b2416181aeda2ce3df77462021-11-11T12:24:15ZParkinson’s Disease Is Associated With Dysregulation of Circulatory Levels of lncRNAs1664-322410.3389/fimmu.2021.763323https://doaj.org/article/5b25aab020b2416181aeda2ce3df77462021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.763323/fullhttps://doaj.org/toc/1664-3224Long non-coding RNAs (lncRNAs) have been recently reported to be involved in the pathoetiology of Parkinson’s disease (PD). Circulatory levels of lncRNAs might be used as markers for PD. In the present work, we measured expression levels of HULC, PVT1, MEG3, SPRY4-IT1, LINC-ROR and DSCAM-AS1 lncRNAs in the circulation of patients with PD versus healthy controls. Expression of HULC was lower in total patients compared with total controls (Expression ratio (ER)=0.19, adjusted P value<0.0001) as well as in female patients compared with female controls (ER=0.071, adjusted P value=0.0004). Expression of PVT1 was lower in total patients compared with total controls (ER=0.55, adjusted P value=0.0124). Expression of DSCAM-AS1 was higher in total patients compared with total controls (ER=5.67, P value=0.0029) and in male patients compared with male controls (ER=9.526, adjusted P value=0.0024). Expression of SPRY4-IT was higher in total patients compared with total controls (ER=2.64, adjusted P value<0.02) and in male patients compared with male controls (ER=3.43, P value<0.03). Expression of LINC-ROR was higher in total patients compared with total controls (ER=10.36, adjusted P value<0.0001) and in both male and female patients compared with sex-matched controls (ER=4.57, adjusted P value=0.03 and ER=23.47, adjusted P value=0.0019, respectively). Finally, expression of MEG3 was higher in total patients compared with total controls (ER=13.94, adjusted P value<0.0001) and in both male and female patients compared with sex-matched controls (ER=8.60, adjusted P value<0.004 and ER=22.58, adjusted P value<0.0085, respectively). ROC curve analysis revealed that MEG3 and LINC-ROR have diagnostic power of 0.77 and 0.73, respectively. Other lncRNAs had AUC values less than 0.7. Expression of none of lncRNAs was correlated with age of patients, disease duration, disease stage, MMSE or UPDRS. The current study provides further evidence for dysregulation of lncRNAs in the circulation of PD patients.Kasra Honarmand TamizkarPooneh GorjiMahdi GholipourBashdar Mahmud HussenMehrdokht MazdehSolat EslamiSolat EslamiMohammad TaheriMohammad TaheriSoudeh Ghafouri-FardFrontiers Media S.A.articleParkinson’s diseaselncRNAHULCPVT1MEG3SPRY4-IT1Immunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease lncRNA HULC PVT1 MEG3 SPRY4-IT1 Immunologic diseases. Allergy RC581-607
spellingShingle	Parkinson’s disease lncRNA HULC PVT1 MEG3 SPRY4-IT1 Immunologic diseases. Allergy RC581-607 Kasra Honarmand Tamizkar Pooneh Gorji Mahdi Gholipour Bashdar Mahmud Hussen Mehrdokht Mazdeh Solat Eslami Solat Eslami Mohammad Taheri Mohammad Taheri Soudeh Ghafouri-Fard Parkinson’s Disease Is Associated With Dysregulation of Circulatory Levels of lncRNAs
description	Long non-coding RNAs (lncRNAs) have been recently reported to be involved in the pathoetiology of Parkinson’s disease (PD). Circulatory levels of lncRNAs might be used as markers for PD. In the present work, we measured expression levels of HULC, PVT1, MEG3, SPRY4-IT1, LINC-ROR and DSCAM-AS1 lncRNAs in the circulation of patients with PD versus healthy controls. Expression of HULC was lower in total patients compared with total controls (Expression ratio (ER)=0.19, adjusted P value<0.0001) as well as in female patients compared with female controls (ER=0.071, adjusted P value=0.0004). Expression of PVT1 was lower in total patients compared with total controls (ER=0.55, adjusted P value=0.0124). Expression of DSCAM-AS1 was higher in total patients compared with total controls (ER=5.67, P value=0.0029) and in male patients compared with male controls (ER=9.526, adjusted P value=0.0024). Expression of SPRY4-IT was higher in total patients compared with total controls (ER=2.64, adjusted P value<0.02) and in male patients compared with male controls (ER=3.43, P value<0.03). Expression of LINC-ROR was higher in total patients compared with total controls (ER=10.36, adjusted P value<0.0001) and in both male and female patients compared with sex-matched controls (ER=4.57, adjusted P value=0.03 and ER=23.47, adjusted P value=0.0019, respectively). Finally, expression of MEG3 was higher in total patients compared with total controls (ER=13.94, adjusted P value<0.0001) and in both male and female patients compared with sex-matched controls (ER=8.60, adjusted P value<0.004 and ER=22.58, adjusted P value<0.0085, respectively). ROC curve analysis revealed that MEG3 and LINC-ROR have diagnostic power of 0.77 and 0.73, respectively. Other lncRNAs had AUC values less than 0.7. Expression of none of lncRNAs was correlated with age of patients, disease duration, disease stage, MMSE or UPDRS. The current study provides further evidence for dysregulation of lncRNAs in the circulation of PD patients.
format	article
author	Kasra Honarmand Tamizkar Pooneh Gorji Mahdi Gholipour Bashdar Mahmud Hussen Mehrdokht Mazdeh Solat Eslami Solat Eslami Mohammad Taheri Mohammad Taheri Soudeh Ghafouri-Fard
author_facet	Kasra Honarmand Tamizkar Pooneh Gorji Mahdi Gholipour Bashdar Mahmud Hussen Mehrdokht Mazdeh Solat Eslami Solat Eslami Mohammad Taheri Mohammad Taheri Soudeh Ghafouri-Fard
author_sort	Kasra Honarmand Tamizkar
title	Parkinson’s Disease Is Associated With Dysregulation of Circulatory Levels of lncRNAs
title_short	Parkinson’s Disease Is Associated With Dysregulation of Circulatory Levels of lncRNAs
title_full	Parkinson’s Disease Is Associated With Dysregulation of Circulatory Levels of lncRNAs
title_fullStr	Parkinson’s Disease Is Associated With Dysregulation of Circulatory Levels of lncRNAs
title_full_unstemmed	Parkinson’s Disease Is Associated With Dysregulation of Circulatory Levels of lncRNAs
title_sort	parkinson’s disease is associated with dysregulation of circulatory levels of lncrnas
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5b25aab020b2416181aeda2ce3df7746
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Parkinson’s Disease Is Associated With Dysregulation of Circulatory Levels of lncRNAs

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