An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer

An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer

The identification of response biomarkers for surgery, chemotherapy and immune checkpoint therapy in bladder cancer is crucial. Here, single nuclei RNA sequencing and spatial profiling identify a cancer cell population expressing Neural Type Cadherin 2 that associates with distinct treatment outcome...

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Autores principales: Kenneth H. Gouin, Nathan Ing, Jasmine T. Plummer, Charles J. Rosser, Bassem Ben Cheikh, Catherine Oh, Stephanie S. Chen, Keith Syson Chan, Hideki Furuya, Warren G. Tourtellotte, Simon R. V. Knott, Dan Theodorescu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5b25f04e5b884ae4a0e99e6169061c15
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Sumario:The identification of response biomarkers for surgery, chemotherapy and immune checkpoint therapy in bladder cancer is crucial. Here, single nuclei RNA sequencing and spatial profiling identify a cancer cell population expressing Neural Type Cadherin 2 that associates with distinct treatment outcomes.

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