An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer

The identification of response biomarkers for surgery, chemotherapy and immune checkpoint therapy in bladder cancer is crucial. Here, single nuclei RNA sequencing and spatial profiling identify a cancer cell population expressing Neural Type Cadherin 2 that associates with distinct treatment outcome...

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Autores principales:	Kenneth H. Gouin, Nathan Ing, Jasmine T. Plummer, Charles J. Rosser, Bassem Ben Cheikh, Catherine Oh, Stephanie S. Chen, Keith Syson Chan, Hideki Furuya, Warren G. Tourtellotte, Simon R. V. Knott, Dan Theodorescu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b25f04e5b884ae4a0e99e6169061c15
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spelling	oai:doaj.org-article:5b25f04e5b884ae4a0e99e6169061c152021-12-02T15:07:48ZAn N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer10.1038/s41467-021-25103-72041-1723https://doaj.org/article/5b25f04e5b884ae4a0e99e6169061c152021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25103-7https://doaj.org/toc/2041-1723The identification of response biomarkers for surgery, chemotherapy and immune checkpoint therapy in bladder cancer is crucial. Here, single nuclei RNA sequencing and spatial profiling identify a cancer cell population expressing Neural Type Cadherin 2 that associates with distinct treatment outcomes.Kenneth H. GouinNathan IngJasmine T. PlummerCharles J. RosserBassem Ben CheikhCatherine OhStephanie S. ChenKeith Syson ChanHideki FuruyaWarren G. TourtellotteSimon R. V. KnottDan TheodorescuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kenneth H. Gouin Nathan Ing Jasmine T. Plummer Charles J. Rosser Bassem Ben Cheikh Catherine Oh Stephanie S. Chen Keith Syson Chan Hideki Furuya Warren G. Tourtellotte Simon R. V. Knott Dan Theodorescu An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer
description	The identification of response biomarkers for surgery, chemotherapy and immune checkpoint therapy in bladder cancer is crucial. Here, single nuclei RNA sequencing and spatial profiling identify a cancer cell population expressing Neural Type Cadherin 2 that associates with distinct treatment outcomes.
format	article
author	Kenneth H. Gouin Nathan Ing Jasmine T. Plummer Charles J. Rosser Bassem Ben Cheikh Catherine Oh Stephanie S. Chen Keith Syson Chan Hideki Furuya Warren G. Tourtellotte Simon R. V. Knott Dan Theodorescu
author_facet	Kenneth H. Gouin Nathan Ing Jasmine T. Plummer Charles J. Rosser Bassem Ben Cheikh Catherine Oh Stephanie S. Chen Keith Syson Chan Hideki Furuya Warren G. Tourtellotte Simon R. V. Knott Dan Theodorescu
author_sort	Kenneth H. Gouin
title	An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer
title_short	An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer
title_full	An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer
title_fullStr	An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer
title_full_unstemmed	An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer
title_sort	n-cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5b25f04e5b884ae4a0e99e6169061c15
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An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer

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