Age-specificity of clinical dengue during primary and secondary infections.

<h4>Background</h4>This study aims to estimate the age-specific risks of clinical dengue attack (i.e., the risk of symptomatic dengue among the total number of dengue virus (DENV) infections) during primary and secondary infections.<h4>Methods</h4>We analyzed two pieces of ep...

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Autores principales:	Khoa T D Thai, Hiroshi Nishiura, Phuong Lan Hoang, Nga Thanh Thi Tran, Giao Trong Phan, Hung Quoc Le, Binh Quang Tran, Nam Van Nguyen, Peter J de Vries
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/5b27715f39f343eabc2a168f069aec3e
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spelling	oai:doaj.org-article:5b27715f39f343eabc2a168f069aec3e2021-11-18T09:13:16ZAge-specificity of clinical dengue during primary and secondary infections.1935-27271935-273510.1371/journal.pntd.0001180https://doaj.org/article/5b27715f39f343eabc2a168f069aec3e2011-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21713018/pdf/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>This study aims to estimate the age-specific risks of clinical dengue attack (i.e., the risk of symptomatic dengue among the total number of dengue virus (DENV) infections) during primary and secondary infections.<h4>Methods</h4>We analyzed two pieces of epidemiological information in Binh Thuan province, southern Vietnam, i.e., age-specific seroprevalence and a community-wide longitudinal study of clinical dengue attack. The latter data set stratified febrile patients with DENV infection by age as well as infection parity. A simple modeling approach was employed to estimate the age-specific risks of clinical dengue attack during primary and secondary infections.<h4>Results</h4>Using the seroprevalence data, the force of infection was estimated to be 11.7% (95% confidence intervals (CI): 10.8-12.7) per year. Median age (and the 25-75 percentiles) of dengue fever patients during primary and secondary infections were 12 (9-20) and 20 (14-31) years, respectively. The estimated age-specific risk of clinical dengue increases as a function of age for both primary and secondary infections; the estimated proportion of symptomatic patients among the total number of infected individuals was estimated to be <7% for those aged <10 years for both primary and secondary infections, but increased as patients become older, reaching to 8-11% by the age of 20 years.<h4>Conclusions/significance</h4>For both primary and secondary infections, higher age at DENV infection was shown to result in higher risk of clinical attack. Age as an important modulator of clinical dengue explains recent increase in dengue notifications in ageing countries in Southeast Asia, and moreover, poses a paradoxical problem of an increase in adult patients resulting from a decline in the force of infection, which may be caused by various factors including time-dependent variations in epidemiological, ecological and demographic dynamics.Khoa T D ThaiHiroshi NishiuraPhuong Lan HoangNga Thanh Thi TranGiao Trong PhanHung Quoc LeBinh Quang TranNam Van NguyenPeter J de VriesPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 5, Iss 6, p e1180 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Khoa T D Thai Hiroshi Nishiura Phuong Lan Hoang Nga Thanh Thi Tran Giao Trong Phan Hung Quoc Le Binh Quang Tran Nam Van Nguyen Peter J de Vries Age-specificity of clinical dengue during primary and secondary infections.
description	<h4>Background</h4>This study aims to estimate the age-specific risks of clinical dengue attack (i.e., the risk of symptomatic dengue among the total number of dengue virus (DENV) infections) during primary and secondary infections.<h4>Methods</h4>We analyzed two pieces of epidemiological information in Binh Thuan province, southern Vietnam, i.e., age-specific seroprevalence and a community-wide longitudinal study of clinical dengue attack. The latter data set stratified febrile patients with DENV infection by age as well as infection parity. A simple modeling approach was employed to estimate the age-specific risks of clinical dengue attack during primary and secondary infections.<h4>Results</h4>Using the seroprevalence data, the force of infection was estimated to be 11.7% (95% confidence intervals (CI): 10.8-12.7) per year. Median age (and the 25-75 percentiles) of dengue fever patients during primary and secondary infections were 12 (9-20) and 20 (14-31) years, respectively. The estimated age-specific risk of clinical dengue increases as a function of age for both primary and secondary infections; the estimated proportion of symptomatic patients among the total number of infected individuals was estimated to be <7% for those aged <10 years for both primary and secondary infections, but increased as patients become older, reaching to 8-11% by the age of 20 years.<h4>Conclusions/significance</h4>For both primary and secondary infections, higher age at DENV infection was shown to result in higher risk of clinical attack. Age as an important modulator of clinical dengue explains recent increase in dengue notifications in ageing countries in Southeast Asia, and moreover, poses a paradoxical problem of an increase in adult patients resulting from a decline in the force of infection, which may be caused by various factors including time-dependent variations in epidemiological, ecological and demographic dynamics.
format	article
author	Khoa T D Thai Hiroshi Nishiura Phuong Lan Hoang Nga Thanh Thi Tran Giao Trong Phan Hung Quoc Le Binh Quang Tran Nam Van Nguyen Peter J de Vries
author_facet	Khoa T D Thai Hiroshi Nishiura Phuong Lan Hoang Nga Thanh Thi Tran Giao Trong Phan Hung Quoc Le Binh Quang Tran Nam Van Nguyen Peter J de Vries
author_sort	Khoa T D Thai
title	Age-specificity of clinical dengue during primary and secondary infections.
title_short	Age-specificity of clinical dengue during primary and secondary infections.
title_full	Age-specificity of clinical dengue during primary and secondary infections.
title_fullStr	Age-specificity of clinical dengue during primary and secondary infections.
title_full_unstemmed	Age-specificity of clinical dengue during primary and secondary infections.
title_sort	age-specificity of clinical dengue during primary and secondary infections.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/5b27715f39f343eabc2a168f069aec3e
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Age-specificity of clinical dengue during primary and secondary infections.

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