Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice

For the first time, the complexation of pentacyclic triterpenes of licorice (glycyrrhizic acid (GA) and its aglycone, glycyrrhetinic acid (GLA)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using both UV/Vis...

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Auteurs principaux:	S. S. Khizrieva, E. V. Vetrova, S. N. Borisenko, E. V. Maksimenko, N. I. Borisenko
Format:	article
Langue:	EN RU
Publié:	Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina 2020
Sujets:	camphecene glycyrrhizic acid glycyrrhetinic acid antiviral activity supramolecular complexes Chemistry QD1-999
Accès en ligne:	https://doaj.org/article/5b299b1f8736402aaf452d0385aad908
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spelling	oai:doaj.org-article:5b299b1f8736402aaf452d0385aad9082021-12-01T05:53:11ZSynthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice2411-141410.15826/chimtech.2020.7.4.10https://doaj.org/article/5b299b1f8736402aaf452d0385aad9082020-12-01T00:00:00Zhttps://journals.urfu.ru/index.php/chimtech/article/view/4808https://doaj.org/toc/2411-1414For the first time, the complexation of pentacyclic triterpenes of licorice (glycyrrhizic acid (GA) and its aglycone, glycyrrhetinic acid (GLA)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using both UV/Vis spectroscopy and mass spectrometry (ESI MS). Formation of the host:guest complexes were registered: GA and GLA molecular complexes (Camph+2GA; Camph+2GLA) with stability constants К = 6.94 106 М-2 and К = 2.89 106 М-2, respectively. The research results demonstrate a considerable potential of ESI MS as a technique for simple and fast detection of formation of the complexes of GA /GLA and the novel drugs.S. S. KhizrievaE. V. VetrovaS. N. BorisenkoE. V. MaksimenkoN. I. BorisenkoUralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina articlecampheceneglycyrrhizic acidglycyrrhetinic acidantiviral activitysupramolecular complexesChemistryQD1-999ENRUChimica Techno Acta, Vol 7, Iss 4, Pp 192-198 (2020)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	camphecene glycyrrhizic acid glycyrrhetinic acid antiviral activity supramolecular complexes Chemistry QD1-999
spellingShingle	camphecene glycyrrhizic acid glycyrrhetinic acid antiviral activity supramolecular complexes Chemistry QD1-999 S. S. Khizrieva E. V. Vetrova S. N. Borisenko E. V. Maksimenko N. I. Borisenko Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice
description	For the first time, the complexation of pentacyclic triterpenes of licorice (glycyrrhizic acid (GA) and its aglycone, glycyrrhetinic acid (GLA)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using both UV/Vis spectroscopy and mass spectrometry (ESI MS). Formation of the host:guest complexes were registered: GA and GLA molecular complexes (Camph+2GA; Camph+2GLA) with stability constants К = 6.94 106 М-2 and К = 2.89 106 М-2, respectively. The research results demonstrate a considerable potential of ESI MS as a technique for simple and fast detection of formation of the complexes of GA /GLA and the novel drugs.
format	article
author	S. S. Khizrieva E. V. Vetrova S. N. Borisenko E. V. Maksimenko N. I. Borisenko
author_facet	S. S. Khizrieva E. V. Vetrova S. N. Borisenko E. V. Maksimenko N. I. Borisenko
author_sort	S. S. Khizrieva
title	Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice
title_short	Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice
title_full	Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice
title_fullStr	Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice
title_full_unstemmed	Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice
title_sort	synthesis and study of complexes of the novel russian antiviral drug camphecene with pentacyclic triterpenes of licorice
publisher	Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina
publishDate	2020
url	https://doaj.org/article/5b299b1f8736402aaf452d0385aad908
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Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice

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