The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac

The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac

Brush border gene regulation in various different tissues is incompletely understood. Here, the authors show HNF4 regulates the brush border gene program in multiple organs, such as intestine, kidney and yolk sac, and also intestinal chromatin looping in these tissues between promoters and enhancers...

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Autores principales: Lei Chen, Shirley Luo, Abigail Dupre, Roshan P. Vasoya, Aditya Parthasarathy, Rohit Aita, Raj Malhotra, Joseph Hur, Natalie H. Toke, Eric Chiles, Min Yang, Weihuan Cao, Juan Flores, Christopher E. Ellison, Nan Gao, Amrik Sahota, Xiaoyang Su, Edward M. Bonder, Michael P. Verzi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/5b2c764533374b2391e6fb24a9437a11
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Sumario:Brush border gene regulation in various different tissues is incompletely understood. Here, the authors show HNF4 regulates the brush border gene program in multiple organs, such as intestine, kidney and yolk sac, and also intestinal chromatin looping in these tissues between promoters and enhancers.

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